SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cyf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4cyf PANTETHEINASE
(Homo
sapiens) 		5 / 12 PHE A 250
HIS A 387
LEU A 215
LEU A 395
TYR A 393
 None
 1.31A 1fm6X-4cyfA:
undetectable		 1fm6X-4cyfA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4cyf PANTETHEINASE
(Homo
sapiens) 		4 / 8 LEU A 223
VAL A 136
ASP A 163
VAL A 165
 None
 0.95A 1iwiA-4cyfA:
undetectable		 1iwiA-4cyfA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4cyf PANTETHEINASE
(Homo
sapiens) 		3 / 3 MET A 239
ASN A  86
GLN A 187
 None
 0.82A 1xoqB-4cyfA:
undetectable		 1xoqB-4cyfA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4cyf PANTETHEINASE
(Homo
sapiens) 		5 / 12 PHE A 250
HIS A 387
LEU A 215
LEU A 395
TYR A 393
 None
 1.38A 2prgB-4cyfA:
undetectable		 2prgB-4cyfA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4cyf PANTETHEINASE
(Homo
sapiens) 		5 / 12 THR A 399
PHE A 431
ASP A 340
PHE A 342
VAL A 337
 None
 1.29A 2vavF-4cyfA:
0.1		 2vavF-4cyfA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 4cyf PANTETHEINASE
(Homo
sapiens) 		4 / 5 ARG A  55
ASN A  56
HIS A  32
ALA A  33
 NAG  A 603 (-3.6A)
None
None
None
 1.23A 3frqA-4cyfA:
0.2		 3frqA-4cyfA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 4cyf PANTETHEINASE
(Homo
sapiens) 		4 / 7 ARG A  55
ASN A  56
HIS A  32
ALA A  33
 NAG  A 603 (-3.6A)
None
None
None
 1.26A 3frqB-4cyfA:
undetectable		 3frqB-4cyfA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4cyf PANTETHEINASE
(Homo
sapiens) 		4 / 8 SER A 265
LEU A  60
ALA A  34
ALA A  33
 None
 1.00A 3ns1L-4cyfA:
undetectable		 3ns1L-4cyfA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 4cyf PANTETHEINASE
(Homo
sapiens) 		5 / 12 SER A 265
LEU A 301
LEU A 299
ALA A  72
LEU A 127
 None
None
None
None
NAG  A 601 ( 4.4A)
 0.86A 3r9cA-4cyfA:
undetectable		 3r9cA-4cyfA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 4cyf PANTETHEINASE
(Homo
sapiens) 		4 / 5 THR A 162
ILE A 139
GLU A  97
PHE A 166
 None
 1.03A 4ac9C-4cyfA:
undetectable		 4ac9C-4cyfA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4cyf PANTETHEINASE
(Homo
sapiens) 		4 / 5 THR A 162
ILE A 139
GLU A  97
PHE A 166
 None
 0.98A 4acaC-4cyfA:
undetectable		 4acaC-4cyfA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4cyf PANTETHEINASE
(Homo
sapiens) 		4 / 5 THR A 162
ILE A 139
GLU A  97
PHE A 166
 None
 1.00A 4acbC-4cyfA:
undetectable		 4acbC-4cyfA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4cyf PANTETHEINASE
(Homo
sapiens) 		4 / 7 LEU A 223
VAL A 136
ASP A 163
VAL A 165
 None
 1.01A 4cp4A-4cyfA:
undetectable		 4cp4A-4cyfA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4cyf PANTETHEINASE
(Homo
sapiens) 		4 / 8 LEU A 223
VAL A 136
ASP A 163
VAL A 165
 None
 1.02A 4l4bA-4cyfA:
undetectable		 4l4bA-4cyfA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 4cyf PANTETHEINASE
(Homo
sapiens) 		3 / 3 ASP A  98
ASP A 141
ASN A 189
 None
 0.71A 4q5mA-4cyfA:
undetectable		 4q5mA-4cyfA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 4cyf PANTETHEINASE
(Homo
sapiens) 		3 / 3 THR A 236
ASN A 266
SER A 265
 CSO  A 211 ( 4.3A)
None
None
 0.73A 4tvtA-4cyfA:
undetectable		 4tvtA-4cyfA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4cyf PANTETHEINASE
(Homo
sapiens) 		5 / 12 PHE A 250
HIS A 387
LEU A 215
LEU A 395
TYR A 393
 None
 1.32A 4xumA-4cyfA:
undetectable		 4xumA-4cyfA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 4cyf PANTETHEINASE
(Homo
sapiens) 		3 / 3 ARG A  89
ASP A 155
TYR A 158
 None
 0.94A 4yo9B-4cyfA:
undetectable		 4yo9B-4cyfA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 4cyf PANTETHEINASE
(Homo
sapiens) 		4 / 8 LEU A  57
ASN A 138
VAL A 164
GLU A  97
 None
 0.90A 4zbqA-4cyfA:
undetectable		 4zbqA-4cyfA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4cyf PANTETHEINASE
(Homo
sapiens) 		4 / 6 VAL A 248
SER A 252
ILE A 214
PHE A 234
 None
None
CSO  A 211 ( 3.9A)
CSO  A 211 ( 4.0A)
 0.99A 5jw1B-4cyfA:
undetectable		 5jw1B-4cyfA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 4cyf PANTETHEINASE
(Homo
sapiens) 		5 / 9 ILE A  75
ALA A  72
ILE A  74
ILE A 279
LEU A 263
 None
 1.08A 5mvmA-4cyfA:
undetectable
5mvmE-4cyfA:
undetectable		 5mvmA-4cyfA:
9.33
5mvmE-4cyfA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 4cyf PANTETHEINASE
(Homo
sapiens) 		4 / 4 PHE A 206
LEU A 301
LEU A 304
VAL A  29
 None
 1.13A 5xxiA-4cyfA:
undetectable		 5xxiA-4cyfA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4cyf PANTETHEINASE
(Homo
sapiens) 		5 / 12 VAL A 224
PHE A 234
PHE A 250
VAL A 260
PHE A 262
 None
CSO  A 211 ( 4.0A)
None
None
None
 1.30A 6ap6A-4cyfA:
undetectable		 6ap6A-4cyfA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4cyf PANTETHEINASE
(Homo
sapiens) 		5 / 12 VAL A 224
PHE A 234
PHE A 250
VAL A 260
PHE A 262
 None
CSO  A 211 ( 4.0A)
None
None
None
 1.32A 6ap6B-4cyfA:
undetectable		 6ap6B-4cyfA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 4cyf PANTETHEINASE
(Homo
sapiens) 		4 / 5 GLN A 179
GLU A 195
ASP A 163
ASN A 189
 None
 1.42A 6iftA-4cyfA:
undetectable		 6iftA-4cyfA:
20.74