SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cyj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 PHE A 438
ALA A 378
SER A 315
TYR A 373
GLY A 372
 None
 1.22A 1kglA-4cyjA:
undetectable		 1kglA-4cyjA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 11 LEU A 464
TYR A 468
GLY A 439
ILE A 374
TYR A 373
 None
 1.14A 1p91A-4cyjA:
undetectable		 1p91A-4cyjA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 11 VAL A 365
ILE A 370
LEU A 445
LEU A 401
LEU A 346
 None
 1.19A 2a15A-4cyjA:
undetectable		 2a15A-4cyjA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		3 / 3 LEU A 244
PRO A 245
LEU A 253
 None
 0.44A 2po7B-4cyjA:
undetectable		 2po7B-4cyjA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		3 / 3 LEU A 244
PRO A 245
LEU A 253
 None
 0.36A 2qd5B-4cyjA:
undetectable		 2qd5B-4cyjA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 11 LEU A 401
ILE A 407
THR A 369
VAL A 365
LEU A 445
 None
 1.13A 3a51A-4cyjA:
undetectable		 3a51A-4cyjA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 401
ILE A 407
THR A 369
VAL A 365
LEU A 445
 None
 1.18A 3a51D-4cyjA:
undetectable		 3a51D-4cyjA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		3 / 3 VAL A 304
LYS A 306
HIS A 385
 None
 0.82A 3elzA-4cyjA:
undetectable		 3elzA-4cyjA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 287
ASN A 278
LEU A 247
THR A 325
TYR A 274
 None
 0.91A 3fsuA-4cyjA:
undetectable		 3fsuA-4cyjA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ASP A 621
PHE A 624
SER A 531
 None
 1.02A 3i5uB-4cyjA:
undetectable		 3i5uB-4cyjA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 5 ASN A 456
ALA A 459
ALA A 460
LYS A 467
 None
 1.00A 3kp2B-4cyjA:
1.4		 3kp2B-4cyjA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		3 / 3 LEU A 244
PRO A 245
LEU A 253
 None
 0.36A 3w1wB-4cyjA:
undetectable		 3w1wB-4cyjA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 5 ILE A 490
ALA A 378
HIS A 492
MET A 494
 None
 1.08A 4ac9B-4cyjA:
undetectable
4ac9C-4cyjA:
undetectable		 4ac9B-4cyjA:
21.37
4ac9C-4cyjA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 5 ILE A 490
ALA A 378
HIS A 492
MET A 494
 None
 1.10A 4acaB-4cyjA:
undetectable
4acaC-4cyjA:
undetectable		 4acaB-4cyjA:
21.37
4acaC-4cyjA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD305_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 4 ILE A 384
LEU A 381
LYS A 382
ASN A 313
 None
 1.19A 4g19D-4cyjA:
undetectable		 4g19D-4cyjA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 4 LEU A 464
SER A 444
LEU A 480
LEU A 472
 None
 0.98A 4n09A-4cyjA:
undetectable		 4n09A-4cyjA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 PHE A 567
LEU A 535
LEU A 590
LEU A 616
TYR A 620
 None
 1.14A 4xumA-4cyjA:
undetectable		 4xumA-4cyjA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		3 / 3 MET A 619
GLN A 618
ARG A 617
 None
 1.00A 5ewzB-4cyjA:
undetectable		 5ewzB-4cyjA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 409
ALA A 380
LEU A 381
TYR A 373
ILE A 407
 None
 1.27A 5ljcA-4cyjA:
undetectable		 5ljcA-4cyjA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		3 / 3 MET A 619
GLN A 618
ARG A 617
 None
 0.93A 5m36A-4cyjA:
undetectable		 5m36A-4cyjA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 9 ILE A 497
ALA A 378
ILE A 442
ALA A 475
LEU A 479
 None
 1.12A 5mvmA-4cyjA:
undetectable
5mvmE-4cyjA:
undetectable		 5mvmA-4cyjA:
11.58
5mvmE-4cyjA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		6 / 10 ILE A 334
LEU A 333
ILE A 414
ALA A 413
ILE A 319
TYR A 337
 None
 1.35A 5mvmD-4cyjA:
undetectable
5mvmE-4cyjA:
undetectable		 5mvmD-4cyjA:
11.58
5mvmE-4cyjA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		3 / 3 HIS A 492
GLU A 486
TRP A 478
 None
 1.23A 5odiD-4cyjA:
undetectable		 5odiD-4cyjA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		3 / 3 HIS A 492
GLU A 486
TRP A 478
 None
 1.21A 5odrD-4cyjA:
undetectable		 5odrD-4cyjA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 7 TYR A 565
THR A 585
VAL A 594
TYR A 613
 None
 1.00A 5ov9A-4cyjA:
undetectable		 5ov9A-4cyjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 445
ILE A 377
TYR A 373
LEU A 409
LEU A 401
 None
 1.24A 6ie8A-4cyjA:
undetectable		 6ie8A-4cyjA:
18.65