SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cyl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 4cyl EFF-1A
(Caenorhabditis
elegans) 		5 / 9 LEU A 465
ILE A 388
VAL A 438
GLY A 414
ALA A 412
 None
 1.00A 1e7aA-4cylA:
undetectable		 1e7aA-4cylA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 4cyl EFF-1A
(Caenorhabditis
elegans) 		3 / 3 ALA A 195
VAL A 204
TRP A 203
 None
 0.94A 1grmA-4cylA:
undetectable		 1grmA-4cylA:
2.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 4cyl EFF-1A
(Caenorhabditis
elegans) 		3 / 3 ALA A 195
VAL A 204
TRP A 203
 None
 0.94A 1grmB-4cylA:
undetectable		 1grmB-4cylA:
2.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4cyl EFF-1A
(Caenorhabditis
elegans) 		4 / 7 ILE A 449
GLU A 360
PHE A 434
ALA A 436
 None
 1.15A 1oniD-4cylA:
undetectable
1oniE-4cylA:
undetectable		 1oniD-4cylA:
12.42
1oniE-4cylA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4cyl EFF-1A
(Caenorhabditis
elegans) 		5 / 12 ASP A 207
LYS A  79
LEU A  56
ILE A 230
THR A 209
 None
 1.09A 1rb2B-4cylA:
undetectable		 1rb2B-4cylA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4cyl EFF-1A
(Caenorhabditis
elegans) 		4 / 6 GLN A  43
PHE A  44
PHE A 381
LEU A 379
 None
 1.02A 3ablP-4cylA:
undetectable
3ablW-4cylA:
undetectable		 3ablP-4cylA:
18.62
3ablW-4cylA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4cyl EFF-1A
(Caenorhabditis
elegans) 		3 / 3 SER A 401
SER A 399
HIS A 242
 None
 0.77A 3mzeA-4cylA:
undetectable		 3mzeA-4cylA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1Q_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4cyl EFF-1A
(Caenorhabditis
elegans) 		5 / 12 PRO A 339
LEU A 404
VAL A 456
TYR A 482
PRO A 453
 None
 1.40A 4g1qA-4cylA:
0.0		 4g1qA-4cylA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 4cyl EFF-1A
(Caenorhabditis
elegans) 		5 / 12 PRO A 339
LEU A 404
VAL A 456
TYR A 482
PRO A 453
 None
 1.35A 4kfbA-4cylA:
1.1		 4kfbA-4cylA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4cyl EFF-1A
(Caenorhabditis
elegans) 		4 / 6 GLN A  43
PHE A  44
PHE A 381
LEU A 379
 None
 0.99A 5b1bC-4cylA:
undetectable
5b1bJ-4cylA:
undetectable		 5b1bC-4cylA:
18.62
5b1bJ-4cylA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 4cyl EFF-1A
(Caenorhabditis
elegans) 		4 / 4 LEU A  85
LEU A  88
GLY A 361
GLU A 360
 None
 1.18A 5hhjA-4cylA:
undetectable		 5hhjA-4cylA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4cyl EFF-1A
(Caenorhabditis
elegans) 		3 / 3 SER A 241
ALA A 240
THR A 187
 None
 0.76A 5n0xB-4cylA:
undetectable		 5n0xB-4cylA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 4cyl EFF-1A
(Caenorhabditis
elegans) 		4 / 8 PHE A 191
ILE A  83
PRO A  22
THR A  21
 None
 1.13A 5x23A-4cylA:
undetectable		 5x23A-4cylA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4cyl EFF-1A
(Caenorhabditis
elegans) 		3 / 3 ARG A 446
HIS A  49
ARG A  84
 None
 0.99A 6dwdD-4cylA:
undetectable		 6dwdD-4cylA:
19.50