SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cym'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 4cym ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens) 		4 / 5 THR D 583
LEU D 585
GLY D 588
TYR D 617
 None
 1.26A 1gtiF-4cymD:
undetectable		 1gtiF-4cymD:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 4cym ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens) 		5 / 12 LEU D 516
LEU D 513
GLN D 509
VAL D 545
LEU D 533
 None
 1.40A 2q7kA-4cymD:
undetectable		 2q7kA-4cymD:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4cym ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens) 		4 / 5 GLU D 563
GLN D 525
HIS D 534
GLY D 561
 None
 1.05A 3pp1A-4cymD:
undetectable		 3pp1A-4cymD:
20.76