SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cyz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cyz HEMAGGLUTININ
(Influenza
A
virus) 		4 / 8 GLY A  68
HIS A  65
THR A  73
ILE A  71
 None
 0.64A 1gtnE-4cyzA:
1.8
1gtnF-4cyzA:
1.8		 1gtnE-4cyzA:
12.13
1gtnF-4cyzA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cyz HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 GLY A  68
HIS A  65
THR A  73
ILE A  71
 None
 0.67A 1gtnF-4cyzA:
1.8
1gtnG-4cyzA:
undetectable		 1gtnF-4cyzA:
12.13
1gtnG-4cyzA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cyz HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 GLY A  68
HIS A  65
THR A  73
ILE A  71
 None
 0.68A 1gtnJ-4cyzA:
1.8
1gtnK-4cyzA:
1.4		 1gtnJ-4cyzA:
12.13
1gtnK-4cyzA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cyz HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 THR A 164
SER A 129
GLY A 249
HIS A 247
 None
 0.94A 1gtnJ-4cyzA:
1.8
1gtnK-4cyzA:
1.4		 1gtnJ-4cyzA:
12.13
1gtnK-4cyzA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4cyz HEMAGGLUTININ
(Influenza
A
virus) 		4 / 8 ASN A 212
SER A 211
VAL A 214
TYR A 209
 None
 0.99A 2wekA-4cyzA:
undetectable		 2wekA-4cyzA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4cyz HEMAGGLUTININ
(Influenza
A
virus) 		4 / 8 ASN A 212
SER A 211
VAL A 214
TYR A 209
 None
 1.02A 2wekB-4cyzA:
undetectable		 2wekB-4cyzA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4cyz HEMAGGLUTININ
(Influenza
A
virus) 		4 / 8 ALA A  95
TYR A 148
ILE A  71
HIS A 233
 None
 1.00A 2zm8A-4cyzA:
undetectable		 2zm8A-4cyzA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4cyz HEMAGGLUTININ
(Influenza
A
virus) 		4 / 8 ALA A  95
TYR A 148
ILE A  71
HIS A 233
 None
 1.03A 2zmaA-4cyzA:
undetectable		 2zmaA-4cyzA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 4cyz HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 PRO A  74
ARG A 141
GLY A 143
ALA A 138
 None
 1.06A 4g0uA-4cyzA:
undetectable		 4g0uA-4cyzA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 4cyz HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 PRO A  74
ARG A 141
GLY A 144
ALA A 138
 None
 1.06A 4g0uA-4cyzA:
undetectable		 4g0uA-4cyzA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N6P_A_JMSA713_1
(LACTOTRANSFERRIN)		 4cyz HEMAGGLUTININ
(Influenza
A
virus) 		4 / 4 HIS A  18
ALA A  19
VAL A  20
GLU A  35
 None
 1.20A 4n6pA-4cyzA:
undetectable		 4n6pA-4cyzA:
21.37