SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cz2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4cz2 RAS-RELATED PROTEIN
RAB-32
(Homo
sapiens) 		5 / 12 THR A  57
GLY A  37
GLY A  35
GLY A  84
ASP A 146
 MG  A1199 ( 2.9A)
GCP  A1198 (-3.3A)
GCP  A1198 (-3.2A)
GCP  A1198 (-4.0A)
GCP  A1198 (-2.7A)
 0.98A 2b25A-4cz2A:
undetectable		 2b25A-4cz2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 4cz2 RAS-RELATED PROTEIN
RAB-32
(Homo
sapiens) 		5 / 12 GLY A  84
LEU A 124
ASP A 123
ARG A  87
PHE A 167
 GCP  A1198 (-4.0A)
None
None
None
None
 1.35A 2b9eA-4cz2A:
undetectable		 2b9eA-4cz2A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4cz2 RAS-RELATED PROTEIN
RAB-32
(Homo
sapiens) 		4 / 6 LEU A  67
VAL A  60
VAL A  28
ILE A  42
 None
 1.16A 2hyyB-4cz2A:
undetectable		 2hyyB-4cz2A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4cz2 RAS-RELATED PROTEIN
RAB-32
(Homo
sapiens) 		4 / 6 LEU A  67
VAL A  60
VAL A  28
ILE A  42
 None
 1.18A 3k5vA-4cz2A:
undetectable		 3k5vA-4cz2A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4cz2 RAS-RELATED PROTEIN
RAB-32
(Homo
sapiens) 		4 / 6 LEU A  67
VAL A  60
VAL A  28
ILE A  42
 None
 1.15A 3k5vB-4cz2A:
undetectable		 3k5vB-4cz2A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4cz2 RAS-RELATED PROTEIN
RAB-32
(Homo
sapiens) 		3 / 3 VAL A  28
HIS A  24
VAL A  75
 None
 0.71A 5jmnC-4cz2A:
undetectable		 5jmnC-4cz2A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 4cz2 RAS-RELATED PROTEIN
RAB-32
(Homo
sapiens) 		3 / 3 LYS A 119
TRP A 120
SER A 122
 None
 1.21A 5nwwA-4cz2A:
undetectable		 5nwwA-4cz2A:
10.00