SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cza'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		5 / 9 GLY A 127
THR A 100
GLY A 360
THR A 129
ILE A 151
 None
 1.13A 1gtfD-4czaA:
undetectable
1gtfE-4czaA:
undetectable		 1gtfD-4czaA:
11.24
1gtfE-4czaA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		5 / 10 GLY A 127
THR A 100
GLY A 360
THR A 129
ILE A 151
 None
 1.12A 1gtfJ-4czaA:
undetectable
1gtfK-4czaA:
undetectable		 1gtfJ-4czaA:
11.24
1gtfK-4czaA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		4 / 7 GLY A 266
LEU A 270
LYS A 269
TYR A 268
 None
 1.07A 1gtiD-4czaA:
undetectable		 1gtiD-4czaA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		4 / 6 THR A 100
GLY A 360
THR A 129
ILE A 151
 None
 0.93A 1gtnD-4czaA:
undetectable
1gtnE-4czaA:
undetectable		 1gtnD-4czaA:
11.24
1gtnE-4czaA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		5 / 10 LEU A 250
ALA A 252
VAL A 257
ALA A 258
LEU A 239
 None
 1.17A 1xp0A-4czaA:
undetectable		 1xp0A-4czaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		5 / 11 GLY A  17
ILE A  49
ILE A  36
PRO A  44
ILE A  42
 None
 1.00A 2b60B-4czaA:
undetectable		 2b60B-4czaA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		4 / 8 PHE A 245
GLY A 247
VAL A 257
LEU A 213
 None
 0.96A 3bgdB-4czaA:
undetectable		 3bgdB-4czaA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		4 / 8 PHE A 245
GLY A 254
VAL A 257
LEU A 209
 None
 0.82A 3bgdB-4czaA:
undetectable		 3bgdB-4czaA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		5 / 12 GLY A 262
GLY A 266
ALA A 240
ALA A 258
LEU A  77
 None
 1.01A 3p2kD-4czaA:
undetectable		 3p2kD-4czaA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		3 / 3 HIS A 388
SER A 320
ASN A 314
 None
 0.82A 3s8pB-4czaA:
0.4		 3s8pB-4czaA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		5 / 12 ILE A 170
LEU A 385
GLY A 123
LEU A 118
GLY A 162
 None
 1.11A 3uq6B-4czaA:
undetectable		 3uq6B-4czaA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		5 / 12 ILE A 170
LEU A 385
GLY A 123
LEU A 118
GLY A 162
 None
 1.10A 3vaqB-4czaA:
undetectable		 3vaqB-4czaA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		5 / 12 ALA A 169
LEU A 173
ALA A 370
ILE A 125
GLY A 119
 None
 0.98A 4r3aB-4czaA:
undetectable		 4r3aB-4czaA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		5 / 12 VAL A 405
PRO A 361
ARG A 362
GLU A 154
GLY A  96
 None
 1.37A 4ydqA-4czaA:
undetectable		 4ydqA-4czaA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		3 / 3 HIS A 388
SER A 320
ASN A 314
 None
 0.85A 5cprB-4czaA:
undetectable		 5cprB-4czaA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		5 / 12 THR A 341
LEU A 339
ALA A 340
ILE A 126
GLY A 127
 None
 1.17A 5gs4A-4czaA:
undetectable		 5gs4A-4czaA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		5 / 12 ASP A 159
ALA A 128
PRO A 361
GLU A 154
SER A 155
 TL  A1423 (-2.1A)
None
None
None
TL  A1423 (-2.1A)
 1.35A 5hfjA-4czaA:
undetectable		 5hfjA-4czaA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		5 / 12 ALA A 124
GLY A 127
ALA A 169
LEU A 173
ALA A 104
 None
 1.35A 5jglB-4czaA:
undetectable		 5jglB-4czaA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		5 / 9 LEU A  46
GLY A  17
ILE A  19
VAL A  41
ILE A  42
 None
 1.14A 5kr2D-4czaA:
undetectable		 5kr2D-4czaA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		5 / 9 GLY A 210
LEU A 213
ILE A 246
GLY A 247
LEU A 250
 None
 0.64A 5vkqC-4czaA:
undetectable
5vkqD-4czaA:
undetectable		 5vkqC-4czaA:
13.78
5vkqD-4czaA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		5 / 12 VAL A 405
PRO A 361
ARG A 362
GLU A 154
GLY A  96
 None
 1.40A 5xioA-4czaA:
undetectable		 5xioA-4czaA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		5 / 12 VAL A 405
PRO A 361
THR A 129
ARG A 362
GLU A 154
 None
 1.50A 5xioB-4czaA:
undetectable		 5xioB-4czaA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		5 / 12 VAL A 405
PRO A 361
ARG A 362
GLU A 154
GLY A  96
 None
 1.33A 5xiqD-4czaA:
undetectable		 5xiqD-4czaA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 4cza NA+/H+ ANTIPORTER,
PUTATIVE
(Pyrococcus
abyssi) 		3 / 3 ARG A 337
GLY A 360
GLU A 359
 None
 0.56A 6fgdA-4czaA:
undetectable		 6fgdA-4czaA:
23.26