SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4czb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		6 / 12 ILE A  32
ALA A 134
ILE A  69
ASP A 132
VAL A 356
LEU A 292
 None
 1.45A 1df7A-4czbA:
undetectable		 1df7A-4czbA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A 168
SER A 169
LEU A  70
VAL A 251
ALA A 194
 None
 1.41A 1q23D-4czbA:
undetectable
1q23E-4czbA:
undetectable		 1q23D-4czbA:
18.31
1q23E-4czbA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		4 / 7 PHE A 124
ILE A  32
ILE A 394
THR A 128
 None
 0.86A 1sbrB-4czbA:
undetectable		 1sbrB-4czbA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A 221
LEU A 228
MET A 254
 None
 0.70A 1ya3B-4czbA:
undetectable		 1ya3B-4czbA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A  34
PRO A  33
LEU A  37
 None
 0.58A 2po7B-4czbA:
undetectable		 2po7B-4czbA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  66
LEU A  70
ILE A 165
ALA A 250
ASP A 234
 None
 1.22A 2q72A-4czbA:
undetectable		 2q72A-4czbA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A 153
ARG A 347
SER A 331
GLY A 323
 None
 0.97A 2qd5B-4czbA:
undetectable		 2qd5B-4czbA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A 289
LEU A  46
PHE A 291
GLY A 293
PRO A  44
 None
 1.40A 2zznB-4czbA:
undetectable		 2zznB-4czbA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A 289
PHE A 291
GLY A 293
PRO A  44
ILE A 288
 None
 1.35A 2zznB-4czbA:
undetectable		 2zznB-4czbA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 256
ILE A 195
VAL A 166
PRO A 162
LEU A 163
 None
 1.39A 3a51B-4czbA:
undetectable		 3a51B-4czbA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  31
ILE A 137
PRO A 346
VAL A 398
ILE A  32
 None
 0.99A 3d1zA-4czbA:
undetectable		 3d1zA-4czbA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		5 / 9 ASP A  31
ILE A 137
PRO A 346
VAL A 398
ILE A  32
 None
 1.07A 3ekyB-4czbA:
undetectable		 3ekyB-4czbA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A  34
PRO A  33
LEU A  37
 None
 0.50A 3hcrA-4czbA:
undetectable		 3hcrA-4czbA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 348
ASP A 132
PRO A 133
ALA A 134
ALA A 353
 None
 1.07A 3jb1A-4czbA:
undetectable		 3jb1A-4czbA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		5 / 9 ASP A  31
ILE A 137
PRO A 346
VAL A 398
ILE A  32
 None
 1.07A 3nu4A-4czbA:
undetectable		 3nu4A-4czbA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		5 / 9 ASP A  31
ILE A 137
PRO A 346
VAL A 398
ILE A  32
 None
 1.10A 3nuoA-4czbA:
undetectable		 3nuoA-4czbA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A 127
GLY A 125
PHE A 124
THR A 390
GLY A 389
 None
 0.91A 4acaB-4czbA:
undetectable
4acaC-4czbA:
undetectable		 4acaB-4czbA:
25.05
4acaC-4czbA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A 259
ALA A  74
GLY A 255
VAL A 222
CYH A 277
 None
 1.33A 4c5lA-4czbA:
undetectable		 4c5lA-4czbA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A 259
ALA A  74
GLY A 255
VAL A 222
CYH A 277
 None
 1.34A 4c5lC-4czbA:
undetectable		 4c5lC-4czbA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A 259
ALA A  74
GLY A 255
VAL A 222
CYH A 277
 None
 1.30A 4c5lD-4czbA:
undetectable		 4c5lD-4czbA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 387
ALA A 352
ALA A 294
LEU A 301
ILE A 388
 None
 0.96A 4kjjA-4czbA:
undetectable		 4kjjA-4czbA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		4 / 5 GLY A 314
SER A 315
ALA A 319
PHE A 317
 None
 0.95A 4m93B-4czbA:
undetectable
4m93C-4czbA:
undetectable		 4m93B-4czbA:
18.40
4m93C-4czbA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		4 / 5 THR A 131
ASN A 160
ASP A  93
LEU A  92
 None
 1.33A 5m0iB-4czbA:
undetectable		 5m0iB-4czbA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		4 / 7 VAL A 139
PRO A  30
ILE A  29
THR A 135
 None
 1.07A 5vkqA-4czbA:
2.0
5vkqD-4czbA:
2.0		 5vkqA-4czbA:
14.02
5vkqD-4czbA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		4 / 7 THR A 135
VAL A 139
PRO A  30
ILE A  29
 None
 1.09A 5vkqA-4czbA:
2.0
5vkqB-4czbA:
2.0		 5vkqA-4czbA:
14.02
5vkqB-4czbA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		4 / 8 THR A 135
VAL A 139
PRO A  30
ILE A  29
 None
 1.09A 5vkqB-4czbA:
2.0
5vkqC-4czbA:
2.0		 5vkqB-4czbA:
14.02
5vkqC-4czbA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		4 / 7 THR A 135
VAL A 139
PRO A  30
ILE A  29
 None
 1.09A 5vkqC-4czbA:
2.0
5vkqD-4czbA:
2.0		 5vkqC-4czbA:
14.02
5vkqD-4czbA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 209
LEU A 221
LEU A 223
ALA A 226
LEU A  71
 None
 1.21A 5y7pG-4czbA:
undetectable		 5y7pG-4czbA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A  92
GLY A 323
LEU A 101
GLY A 125
 None
 0.76A 6eu9D-4czbA:
undetectable		 6eu9D-4czbA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A 187
LEU A  98
THR A 168
ARG A 320
 None
 1.08A 6ew0G-4czbA:
undetectable		 6ew0G-4czbA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 320
PHE A 159
PHE A 341
 None
 1.02A 6nknC-4czbA:
1.4
6nknJ-4czbA:
undetectable		 6nknC-4czbA:
22.04
6nknJ-4czbA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4czb NA(+)/H(+)
ANTIPORTER 1
(Methanocaldococc
us
jannaschii) 		4 / 7 ALA A 294
GLY A 293
LEU A  40
GLY A  17
 None
 0.83A 6nm4A-4czbA:
undetectable		 6nm4A-4czbA:
17.28