SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cze'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		5 / 12 ALA A 132
ALA A 130
ILE A 138
CYH A 328
LEU A 332
 None
 1.02A 1fm6U-4czeA:
undetectable		 1fm6U-4czeA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		5 / 12 PRO A 320
ALA A 256
LEU A 259
ALA A 260
ILE A 163
 None
 1.20A 2jjpA-4czeA:
undetectable		 2jjpA-4czeA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		4 / 7 ILE A  89
ILE A  79
LEU A 137
VAL A 135
 None
 0.88A 3ua5B-4czeA:
undetectable		 3ua5B-4czeA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		5 / 12 CYH A 323
GLY A 329
LYS A 330
LEU A 321
GLY A 294
 None
 0.99A 4fp9A-4czeA:
undetectable		 4fp9A-4czeA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		5 / 12 CYH A 323
GLY A 329
LYS A 330
LEU A 321
GLY A 294
 None
 1.02A 4fp9C-4czeA:
undetectable		 4fp9C-4czeA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		5 / 12 CYH A 323
GLY A 329
LYS A 330
LEU A 321
GLY A 294
 None
 1.00A 4fp9D-4czeA:
undetectable		 4fp9D-4czeA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		5 / 12 CYH A 323
GLY A 329
LYS A 330
LEU A 321
GLY A 294
 None
 1.02A 4fp9F-4czeA:
undetectable		 4fp9F-4czeA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		5 / 12 CYH A 323
GLY A 329
LYS A 330
LEU A 321
GLY A 294
 None
 1.04A 4fzvA-4czeA:
undetectable		 4fzvA-4czeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		5 / 10 ASN A  11
ILE A  13
VAL A  96
VAL A 109
VAL A 107
 None
 1.06A 4j5jB-4czeA:
undetectable		 4j5jB-4czeA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		5 / 10 SER A 176
ILE A 138
VAL A 331
ALA A 145
ILE A 146
 None
 0.99A 4lbgA-4czeA:
undetectable		 4lbgA-4czeA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		5 / 10 GLY A 165
GLY A 188
GLU A 213
LYS A 216
GLY A 295
 PO4  A1334 (-3.7A)
None
None
None
None
 0.85A 5aqfA-4czeA:
25.2		 5aqfA-4czeA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		5 / 10 GLY A 165
GLY A 188
GLU A 213
LYS A 216
GLY A 295
 PO4  A1334 (-3.7A)
None
None
None
None
 0.84A 5aqfC-4czeA:
25.1		 5aqfC-4czeA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		5 / 10 GLY A 165
GLY A 188
GLU A 213
LYS A 216
GLY A 295
 PO4  A1334 (-3.7A)
None
None
None
None
 0.85A 5aqyA-4czeA:
26.8		 5aqyA-4czeA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		5 / 12 LEU A 292
ALA A 317
ILE A 163
GLY A 295
LEU A 150
 None
 1.04A 5nfjB-4czeA:
undetectable		 5nfjB-4czeA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		5 / 12 LEU A 292
ALA A 317
ILE A 163
GLY A 296
LEU A 150
 None
 1.10A 5nfjB-4czeA:
undetectable		 5nfjB-4czeA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		5 / 12 LEU A 292
ALA A 317
ILE A 163
GLY A 295
LEU A 150
 None
 1.02A 5nfjC-4czeA:
undetectable		 5nfjC-4czeA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		5 / 12 MET A  88
ILE A  24
VAL A 109
CYH A 110
ASP A  12
 None
 1.14A 5vlmG-4czeA:
undetectable		 5vlmG-4czeA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		3 / 3 LEU A 205
VAL A 235
ASP A 234
 None
 0.63A 5x23A-4czeA:
undetectable		 5x23A-4czeA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		4 / 6 PRO A 320
GLY A 294
LEU A 302
VAL A 316
 None
 0.90A 5x80A-4czeA:
1.6
5x80B-4czeA:
1.7		 5x80A-4czeA:
18.26
5x80B-4czeA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		6 / 12 GLY A 164
GLY A 187
LEU A 298
GLY A 295
GLY A 294
PRO A 320
 PO4  A1334 (-3.5A)
None
None
None
None
None
 1.20A 5zhmB-4czeA:
undetectable		 5zhmB-4czeA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		3 / 3 SER A 251
LYS A 229
SER A 232
 None
 0.72A 6az3P-4czeA:
undetectable		 6az3P-4czeA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4cze ROD
SHAPE-DETERMINING
PROTEIN MREB
(Caulobacter
vibrioides) 		5 / 12 GLY A 165
GLY A 188
ARG A  72
SER A  37
ASP A  76
 PO4  A1334 (-3.7A)
None
None
None
None
 1.30A 6clxA-4czeA:
undetectable		 6clxA-4czeA:
24.88