SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4czt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23
(Arabidopsis
thaliana) 		5 / 11 ILE A 308
PHE A 309
LEU A 178
PRO A 179
ILE A  80
 None
None
None
SO4  A1317 (-4.7A)
None
 1.08A 1dg5A-4cztA:
undetectable		 1dg5A-4cztA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23
(Arabidopsis
thaliana) 		4 / 6 LEU A 240
TYR A 241
ILE A 244
GLY A 193
 None
 0.77A 2du8A-4cztA:
undetectable		 2du8A-4cztA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23
(Arabidopsis
thaliana) 		4 / 6 LEU A 240
TYR A 241
ILE A 244
GLY A 193
 None
 0.82A 2du8B-4cztA:
undetectable		 2du8B-4cztA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23
(Arabidopsis
thaliana) 		3 / 3 ASN A 196
ASP A 154
GLN A 180
 None
 0.80A 3eeyC-4cztA:
undetectable		 3eeyC-4cztA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23
(Arabidopsis
thaliana) 		3 / 3 ASN A 196
ASP A 154
GLN A 180
 None
 0.81A 3eeyD-4cztA:
undetectable		 3eeyD-4cztA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23
(Arabidopsis
thaliana) 		3 / 3 ASN A 196
ASP A 154
GLN A 180
 None
 0.79A 3eeyE-4cztA:
undetectable		 3eeyE-4cztA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23
(Arabidopsis
thaliana) 		5 / 11 GLY A 113
ASP A 163
ALA A 167
GLY A 166
VAL A 111
 CPS  A1316 (-3.9A)
SO4  A1318 (-4.6A)
None
None
SO4  A1318 (-3.8A)
 1.13A 4c5lA-4cztA:
undetectable		 4c5lA-4cztA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23
(Arabidopsis
thaliana) 		5 / 9 GLY A 113
ASP A 163
ALA A 167
GLY A 166
VAL A 111
 CPS  A1316 (-3.9A)
SO4  A1318 (-4.6A)
None
None
SO4  A1318 (-3.8A)
 1.16A 4c5lB-4cztA:
undetectable		 4c5lB-4cztA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23
(Arabidopsis
thaliana) 		5 / 10 GLY A 113
ASP A 163
ALA A 167
GLY A 166
VAL A 111
 CPS  A1316 (-3.9A)
SO4  A1318 (-4.6A)
None
None
SO4  A1318 (-3.8A)
 1.11A 4c5lC-4cztA:
undetectable		 4c5lC-4cztA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23
(Arabidopsis
thaliana) 		5 / 10 GLY A 113
ASP A 163
ALA A 167
GLY A 166
VAL A 111
 CPS  A1316 (-3.9A)
SO4  A1318 (-4.6A)
None
None
SO4  A1318 (-3.8A)
 1.13A 4c5lD-4cztA:
undetectable		 4c5lD-4cztA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23
(Arabidopsis
thaliana) 		5 / 10 GLY A 113
ASP A 163
ALA A 167
GLY A 166
VAL A 111
 CPS  A1316 (-3.9A)
SO4  A1318 (-4.6A)
None
None
SO4  A1318 (-3.8A)
 1.16A 4c5nB-4cztA:
undetectable		 4c5nB-4cztA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23
(Arabidopsis
thaliana) 		5 / 10 GLY A 113
ASP A 163
ALA A 167
GLY A 166
VAL A 111
 CPS  A1316 (-3.9A)
SO4  A1318 (-4.6A)
None
None
SO4  A1318 (-3.8A)
 1.14A 4c5nD-4cztA:
undetectable		 4c5nD-4cztA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23
(Arabidopsis
thaliana) 		4 / 6 ARG A  78
GLY A 149
ALA A 177
GLU A  79
 None
 1.11A 4g0uA-4cztA:
3.0		 4g0uA-4cztA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23
(Arabidopsis
thaliana) 		4 / 7 LYS A  87
TYR A 144
LEU A 138
PHE A 135
 None
 1.12A 4yv5A-4cztA:
undetectable		 4yv5A-4cztA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23
(Arabidopsis
thaliana) 		5 / 12 GLY A 193
SER A 217
PHE A 232
TYR A 241
LEU A 240
 None
 1.37A 5czyA-4cztA:
undetectable		 5czyA-4cztA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23
(Arabidopsis
thaliana) 		4 / 7 GLY A  38
GLY A  40
VAL A  45
LYS A  60
 None
None
None
CPS  A1316 ( 4.8A)
 0.48A 5izjA-4cztA:
19.6		 5izjA-4cztA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23
(Arabidopsis
thaliana) 		4 / 8 ASP A 172
LEU A 175
THR A 190
VAL A  45
 CPS  A1316 (-3.9A)
None
None
None
 1.12A 5ov9B-4cztA:
undetectable		 5ov9B-4cztA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23
(Arabidopsis
thaliana) 		3 / 3 HIS A 152
SER A 171
ARG A 183
 None
CPS  A1316 (-4.0A)
None
 0.96A 5u63A-4cztA:
undetectable		 5u63A-4cztA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23
(Arabidopsis
thaliana) 		3 / 3 TYR A 144
HIS A  88
PHE A 295
 None
 0.82A 6esmA-4cztA:
undetectable		 6esmA-4cztA:
12.66