SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4czx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		5 / 12 VAL A 225
SER A 198
SER A 159
CYH A 163
VAL A 246
 None
 1.35A 1db1A-4czxA:
undetectable		 1db1A-4czxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		5 / 12 VAL A 225
SER A 198
SER A 159
CYH A 163
VAL A 246
 None
 1.34A 1ie9A-4czxA:
undetectable		 1ie9A-4czxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Neurospora
crassa) 		3 / 3 ARG A 104
ILE A  64
TRP B 566
 PO4  A 401 (-4.0A)
None
None
 1.08A 1m8eB-4czxA:
undetectable		 1m8eB-4czxA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		5 / 9 GLU A  67
ARG A  63
ALA A  24
HIS A  23
PRO A  20
 None
 1.10A 1mj2A-4czxA:
undetectable		 1mj2A-4czxA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		5 / 9 GLU A  67
ARG A  63
ALA A  24
HIS A  23
PRO A  20
 None
 1.08A 1mjoA-4czxA:
undetectable		 1mjoA-4czxA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		5 / 9 GLU A  67
ARG A  63
ALA A  24
HIS A  23
PRO A  20
 None
 1.09A 1mjoB-4czxA:
undetectable		 1mjoB-4czxA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		5 / 9 GLU A  67
ARG A  63
ALA A  24
HIS A  23
PRO A  20
 None
 1.06A 1mjoC-4czxA:
undetectable		 1mjoC-4czxA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		5 / 12 GLU A  67
ARG A  63
ALA A  24
HIS A  23
PRO A  20
 None
 1.11A 1mjqC-4czxA:
undetectable
1mjqD-4czxA:
undetectable		 1mjqC-4czxA:
12.18
1mjqD-4czxA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		5 / 10 GLU A  67
ARG A  63
ALA A  24
HIS A  23
PRO A  20
 None
 1.00A 1mjqG-4czxA:
undetectable
1mjqH-4czxA:
undetectable		 1mjqG-4czxA:
12.18
1mjqH-4czxA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		5 / 12 GLU A  67
ARG A  63
ALA A  24
HIS A  23
PRO A  20
 None
 1.11A 1mjqI-4czxA:
undetectable
1mjqJ-4czxA:
undetectable		 1mjqI-4czxA:
12.18
1mjqJ-4czxA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Neurospora
crassa) 		3 / 3 ARG A 104
ILE A  64
TRP B 566
 PO4  A 401 (-4.0A)
None
None
 1.00A 1nodB-4czxA:
undetectable		 1nodB-4czxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Neurospora
crassa) 		3 / 3 ARG A 104
ILE A  64
TRP B 566
 PO4  A 401 (-4.0A)
None
None
 0.95A 1qomA-4czxA:
undetectable		 1qomA-4czxA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		5 / 12 VAL A 225
SER A 198
SER A 159
CYH A 163
VAL A 246
 None
 1.31A 1rk3A-4czxA:
undetectable		 1rk3A-4czxA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		4 / 6 ILE A 181
VAL A 143
ILE A 124
ILE A 103
 None
 0.79A 1uwhA-4czxA:
undetectable		 1uwhA-4czxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Neurospora
crassa) 		3 / 3 LEU B 616
LEU B 573
MET B 635
 None
 0.80A 1ya3B-4czxB:
undetectable		 1ya3B-4czxB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		5 / 11 ARG A  73
ILE A  30
LEU A  39
PHE A  51
GLY A  49
 None
 1.37A 2bxmA-4czxA:
undetectable		 2bxmA-4czxA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		4 / 7 HIS A 249
ASP A   5
THR A 295
GLY A 296
 None
 1.01A 2f6dA-4czxA:
undetectable		 2f6dA-4czxA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		4 / 5 ASP A 200
LEU A 228
MET A 231
ARG A 160
 None
 1.23A 2gj5A-4czxA:
undetectable		 2gj5A-4czxA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Neurospora
crassa) 		3 / 3 ARG A 104
ILE A  64
TRP B 566
 PO4  A 401 (-4.0A)
None
None
 1.04A 2nodB-4czxA:
undetectable		 2nodB-4czxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		5 / 11 ILE A 124
PHE A  84
ILE A 100
PRO A  99
VAL A 138
 None
 1.16A 2w3aA-4czxA:
undetectable		 2w3aA-4czxA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Neurospora
crassa;
Neurospora
crassa) 		4 / 7 SER A  96
GLN B 634
ILE A 100
SER B 631
 None
 0.97A 2xz5A-4czxA:
undetectable
2xz5B-4czxA:
undetectable		 2xz5A-4czxA:
22.76
2xz5B-4czxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Neurospora
crassa;
Neurospora
crassa) 		4 / 8 SER A  96
GLN B 634
ILE A 100
SER B 631
 None
 0.97A 2xz5B-4czxA:
undetectable
2xz5E-4czxA:
undetectable		 2xz5B-4czxA:
22.76
2xz5E-4czxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		5 / 12 VAL A 225
SER A 198
SER A 159
CYH A 163
VAL A 246
 None
 1.34A 2zlcA-4czxA:
undetectable		 2zlcA-4czxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Neurospora
crassa) 		3 / 3 ARG A 104
ILE A  64
TRP B 566
 PO4  A 401 (-4.0A)
None
None
 1.14A 3e68A-4czxA:
undetectable		 3e68A-4czxA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Neurospora
crassa) 		3 / 3 ARG A 104
ILE A  64
TRP B 566
 PO4  A 401 (-4.0A)
None
None
 1.05A 3e6tB-4czxA:
undetectable		 3e6tB-4czxA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Neurospora
crassa) 		3 / 3 ARG A 104
ILE A  64
TRP B 566
 PO4  A 401 (-4.0A)
None
None
 0.95A 3e7iB-4czxA:
undetectable		 3e7iB-4czxA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Neurospora
crassa) 		3 / 3 ASN B 597
HIS B 598
VAL B 582
 None
 0.81A 3elzB-4czxB:
undetectable		 3elzB-4czxB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		4 / 8 LYS A 299
HIS A 249
LEU A   9
ASP A   5
 None
 1.11A 3n2oC-4czxA:
undetectable
3n2oD-4czxA:
undetectable		 3n2oC-4czxA:
18.24
3n2oD-4czxA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Neurospora
crassa) 		3 / 3 ARG A 104
ILE A  64
TRP B 566
 PO4  A 401 (-4.0A)
None
None
 1.10A 3nw2A-4czxA:
undetectable		 3nw2A-4czxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Neurospora
crassa) 		3 / 3 ARG A 104
ILE A  64
TRP B 566
 PO4  A 401 (-4.0A)
None
None
 1.01A 3nw2B-4czxA:
undetectable		 3nw2B-4czxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		5 / 12 VAL A 225
SER A 198
SER A 159
CYH A 163
VAL A 246
 None
 1.33A 3vt3A-4czxA:
undetectable		 3vt3A-4czxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		4 / 7 ARG A  73
GLY A  86
ILE A  64
GLN A 109
 None
 0.88A 4g0vA-4czxA:
undetectable		 4g0vA-4czxA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		5 / 12 VAL A 225
SER A 198
SER A 159
CYH A 163
VAL A 246
 None
 1.25A 4rujA-4czxA:
undetectable		 4rujA-4czxA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		5 / 12 ARG A 160
PHE A 201
THR A 197
THR A 254
LEU A 271
 None
 1.46A 4z7fC-4czxA:
undetectable		 4z7fC-4czxA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Neurospora
crassa) 		5 / 7 ILE A  83
VAL B 626
PHE B 625
ASN A  34
PHE A  59
 None
 1.47A 5hieC-4czxA:
undetectable		 5hieC-4czxA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		4 / 7 ILE A 192
LEU A 219
ALA A 243
HIS A 188
 None
 0.88A 5hrqE-4czxA:
undetectable
5hrqF-4czxA:
undetectable
5hrqJ-4czxA:
undetectable		 5hrqE-4czxA:
4.89
5hrqF-4czxA:
7.61
5hrqJ-4czxA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		4 / 6 HIS A 245
ALA A 256
LEU A 270
TYR A 222
 None
 1.08A 5igiA-4czxA:
undetectable		 5igiA-4czxA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Neurospora
crassa;
Neurospora
crassa) 		5 / 12 GLY A  86
GLU B 568
PHE A  62
ARG A  63
ALA A  48
 None
 1.25A 5ih0A-4czxA:
1.3		 5ih0A-4czxA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		4 / 5 GLN A 109
ASP A 110
SER A  87
ARG A  73
 None
 1.41A 5w4zA-4czxA:
undetectable		 5w4zA-4czxA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		4 / 5 GLN A 109
ASP A 110
SER A  87
ARG A 112
 None
 1.27A 5w4zA-4czxA:
undetectable		 5w4zA-4czxA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Neurospora
crassa) 		5 / 11 PHE A 290
VAL A 259
THR A 281
THR A 308
VAL A 310
 None
 1.45A 6hcoA-4czxA:
undetectable
6hcoB-4czxA:
undetectable		 6hcoA-4czxA:
18.36
6hcoB-4czxA:
18.36