SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 4d05 ATP-DEPENDENT DNA
LIGASE
(Psychromonas
sp.
SP041) 		4 / 8 GLU A 207
ALA A 182
GLU A 178
ALA A 248
 None
 0.91A 1ie4B-4d05A:
undetectable
1ie4D-4d05A:
undetectable		 1ie4B-4d05A:
18.99
1ie4D-4d05A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4d05 ATP-DEPENDENT DNA
LIGASE
(Psychromonas
sp.
SP041) 		3 / 3 GLU A 221
ASP A 219
TYR A 194
 None
 0.77A 2yvlB-4d05A:
undetectable		 2yvlB-4d05A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 4d05 ATP-DEPENDENT DNA
LIGASE
(Psychromonas
sp.
SP041) 		3 / 3 GLU A 107
HIS A 157
HIS A 158
 None
 0.64A 3co4A-4d05A:
undetectable		 3co4A-4d05A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 4d05 ATP-DEPENDENT DNA
LIGASE
(Psychromonas
sp.
SP041) 		4 / 5 SER A  76
GLY A  77
GLU A  73
PHE A  72
 None
 1.22A 4r82A-4d05A:
undetectable
4r82B-4d05A:
undetectable		 4r82A-4d05A:
20.74
4r82B-4d05A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4d05 ATP-DEPENDENT DNA
LIGASE
(Psychromonas
sp.
SP041) 		5 / 12 HIS A  36
TYR A  32
GLN A  37
LYS A   0
ILE A  39
 None
 1.50A 4ynmA-4d05A:
undetectable		 4ynmA-4d05A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 4d05 ATP-DEPENDENT DNA
LIGASE
(Psychromonas
sp.
SP041) 		4 / 6 ILE A  96
PHE A  97
PHE A  52
TRP A  89
 None
AMP  A1263 (-3.4A)
None
None
 1.30A 5g08A-4d05A:
undetectable		 5g08A-4d05A:
23.22