SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4d0k A-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Chaetomium
thermophilum) 		4 / 7 VAL A  46
GLY A  44
THR A  85
ILE A  62
 None
 0.80A 1gtnC-4d0kA:
undetectable
1gtnD-4d0kA:
undetectable		 1gtnC-4d0kA:
10.50
1gtnD-4d0kA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 8 SER B 538
ARG B 540
GLN B 484
ASN B 523
 None
 1.16A 1p6kB-4d0kB:
undetectable		 1p6kB-4d0kB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 8 SER B 538
ARG B 540
GLN B 484
ASN B 523
 None
 1.16A 1rs6B-4d0kB:
undetectable		 1rs6B-4d0kB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 8 SER B 538
ARG B 540
GLN B 484
ASN B 523
 None
 1.09A 1rs7B-4d0kB:
undetectable		 1rs7B-4d0kB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		3 / 3 LEU B 542
PHE B 488
ARG B 453
 None
 0.80A 1xdkF-4d0kB:
undetectable		 1xdkF-4d0kB:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 8 SER B 538
ARG B 540
GLN B 484
ASN B 523
 None
 1.19A 1zzqA-4d0kB:
undetectable		 1zzqA-4d0kB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 8 SER B 538
ARG B 540
GLN B 484
ASN B 523
 None
 1.12A 1zzqB-4d0kB:
undetectable		 1zzqB-4d0kB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 8 SER B 538
ARG B 540
GLN B 484
ASN B 523
 None
 1.17A 1zzuB-4d0kB:
undetectable		 1zzuB-4d0kB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4d0k A-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		5 / 12 LEU B 485
GLY B 480
ASP B 481
ALA A  97
ALA A  91
 None
 1.28A 2br4B-4d0kB:
undetectable		 2br4B-4d0kB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 4d0k A-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Chaetomium
thermophilum) 		5 / 12 LEU A  54
LEU A 287
GLY A 300
VAL A  28
ALA A  39
 None
 1.12A 2kceB-4d0kA:
undetectable		 2kceB-4d0kA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 4d0k A-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Chaetomium
thermophilum) 		3 / 3 PHE A  49
CYH A  47
PHE A  41
 None
 1.06A 3cr5X-4d0kA:
undetectable		 3cr5X-4d0kA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4d0k A-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Chaetomium
thermophilum) 		3 / 3 ASN A 228
MET A 235
PHE A 199
 None
 1.07A 3g4lD-4d0kA:
undetectable		 3g4lD-4d0kA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4d0k A-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Chaetomium
thermophilum) 		5 / 9 PHE A 288
VAL A 285
GLY A 300
VAL A 256
GLY A 261
 None
 1.38A 3kmoA-4d0kA:
undetectable		 3kmoA-4d0kA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 8 SER B 538
ARG B 540
GLN B 484
ASN B 523
 None
 1.07A 3n62A-4d0kB:
undetectable		 3n62A-4d0kB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 8 SER B 538
ARG B 540
GLN B 484
ASN B 523
 None
 1.25A 3n62B-4d0kB:
undetectable		 3n62B-4d0kB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 8 SER B 538
ARG B 540
GLN B 484
ASN B 523
 None
 1.08A 3n66B-4d0kB:
undetectable		 3n66B-4d0kB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 8 TYR B 539
LEU B 526
TYR B 491
PHE B 488
 None
 1.32A 3po7A-4d0kB:
undetectable		 3po7A-4d0kB:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 4d0k A-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Chaetomium
thermophilum) 		4 / 7 ARG A  71
GLY A  84
ILE A  62
GLN A 128
 None
 1.01A 4g0vA-4d0kA:
undetectable		 4g0vA-4d0kA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4d0k A-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Chaetomium
thermophilum) 		4 / 7 ILE A 299
THR A 257
VAL A   8
ASP A   4
 None
 1.28A 4iarA-4d0kA:
undetectable		 4iarA-4d0kA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 4d0k A-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Chaetomium
thermophilum) 		3 / 3 TRP A 127
GLN A 148
THR A 164
 None
 0.99A 4m2xA-4d0kA:
undetectable		 4m2xA-4d0kA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 PHE B 493
LEU B 461
LEU B 516
LEU B 542
TYR B 546
 None
 1.17A 4xumA-4d0kB:
undetectable		 4xumA-4d0kB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 4d0k A-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Chaetomium
thermophilum) 		3 / 3 PRO A 248
ILE A 160
SER A 293
 None
 0.73A 5fsaA-4d0kA:
undetectable		 5fsaA-4d0kA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4d0k A-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Chaetomium
thermophilum) 		4 / 7 ILE A 190
LEU A 217
ALA A 241
HIS A 186
 None
 0.96A 5hrqE-4d0kA:
undetectable
5hrqF-4d0kA:
undetectable
5hrqJ-4d0kA:
undetectable		 5hrqE-4d0kA:
4.25
5hrqF-4d0kA:
4.80
5hrqJ-4d0kA:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 7 TYR B 491
THR B 511
VAL B 520
TYR B 539
 None
 1.01A 5ov9A-4d0kB:
undetectable		 5ov9A-4d0kB:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 8 SER B 538
ARG B 540
GLN B 484
ASN B 523
 None
 1.18A 5vunA-4d0kB:
undetectable		 5vunA-4d0kB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 8 SER B 538
ARG B 540
GLN B 484
ASN B 523
 None
 1.14A 5vunB-4d0kB:
undetectable		 5vunB-4d0kB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 8 SER B 538
ARG B 540
GLN B 484
ASN B 523
 None
 1.14A 5vuoB-4d0kB:
undetectable		 5vuoB-4d0kB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 8 SER B 538
ARG B 540
GLN B 484
ASN B 523
 None
 1.14A 6auuB-4d0kB:
undetectable		 6auuB-4d0kB:
16.92