SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 4d0m RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		5 / 12 ILE B  60
THR B 153
VAL B 161
LEU B  16
ILE B  64
 None
 1.01A 1kqwA-4d0mB:
undetectable		 1kqwA-4d0mB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4d0m RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		3 / 3 ARG B  82
VAL B  15
TRP B  65
 None
 1.19A 1qw6A-4d0mB:
undetectable		 1qw6A-4d0mB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4d0m RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		3 / 3 ARG B  82
VAL B  15
TRP B  65
 None
 1.22A 1qwcA-4d0mB:
undetectable		 1qwcA-4d0mB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4d0m RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		3 / 3 ARG B  82
VAL B  15
TRP B  65
 None
 1.16A 1vagA-4d0mB:
undetectable		 1vagA-4d0mB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4d0m RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		3 / 3 ARG B  82
VAL B  15
TRP B  65
 None
 1.16A 1zviA-4d0mB:
undetectable		 1zviA-4d0mB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4d0m RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		5 / 12 THR B  43
GLY B  23
GLY B  21
GLY B  69
ASP B 127
 MG  B2001 ( 2.7A)
GSP  B2000 (-3.0A)
GSP  B2000 (-3.5A)
GSP  B2000 (-4.1A)
GSP  B2000 (-2.9A)
 0.99A 2b25A-4d0mB:
undetectable		 2b25A-4d0mB:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4d0m RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		4 / 8 TYR B  91
GLU B 152
PHE B 150
TYR B  99
 None
 1.12A 2fl5E-4d0mB:
undetectable
2fl5F-4d0mB:
undetectable		 2fl5E-4d0mB:
23.60
2fl5F-4d0mB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4d0m RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		4 / 8 TYR B  91
GLU B 152
PHE B 150
VAL B 102
 None
 0.70A 2fl5E-4d0mB:
undetectable
2fl5F-4d0mB:
undetectable		 2fl5E-4d0mB:
23.60
2fl5F-4d0mB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4d0m RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		4 / 7 VAL B  46
ARG B  82
VAL B  15
TRP B  65
 None
 1.23A 3jx6A-4d0mB:
undetectable
3jx6B-4d0mB:
undetectable		 3jx6A-4d0mB:
21.63
3jx6B-4d0mB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 4d0m RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		5 / 12 GLY B  86
ALA B  84
PHE B  12
ILE B 168
VAL B 118
 None
 1.26A 4azsA-4d0mB:
undetectable		 4azsA-4d0mB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 4d0m RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		5 / 12 GLY B  86
ALA B  84
PHE B  12
ILE B 168
VAL B 118
 None
 1.26A 4azwA-4d0mB:
undetectable		 4azwA-4d0mB:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4d0m RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		4 / 6 VAL B  46
ARG B  82
VAL B  15
TRP B  65
 None
 1.43A 5adeA-4d0mB:
undetectable
5adeB-4d0mB:
undetectable		 5adeA-4d0mB:
21.63
5adeB-4d0mB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4d0m RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		3 / 3 ARG B  82
VAL B  15
TRP B  65
 None
 1.24A 5fvoA-4d0mB:
undetectable		 5fvoA-4d0mB:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4d0m RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		3 / 3 THR B  98
THR B 153
LEU B  88
 None
 0.69A 5m66D-4d0mB:
undetectable		 5m66D-4d0mB:
18.16