SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d0o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
5 / 12 ILE A2078
ILE A2003
ILE A2164
VAL A2084
LEU A2085
None
1.01A 1qhsA-4d0oA:
undetectable
1qhsA-4d0oA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
6 / 12 ILE A2078
ILE A2003
ILE A2164
ASP A2083
VAL A2084
LEU A2085
None
1.21A 1qhyA-4d0oA:
undetectable
1qhyA-4d0oA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 8 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.69A 1v54C-4d0oA:
3.6
1v54J-4d0oA:
undetectable
1v54C-4d0oA:
17.79
1v54J-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 8 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.70A 2dyrC-4d0oA:
3.6
2dyrJ-4d0oA:
undetectable
2dyrC-4d0oA:
17.79
2dyrJ-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 7 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.74A 2eikC-4d0oA:
3.6
2eikJ-4d0oA:
undetectable
2eikC-4d0oA:
17.79
2eikJ-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 8 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.69A 2eikP-4d0oA:
3.6
2eikW-4d0oA:
undetectable
2eikP-4d0oA:
17.79
2eikW-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 8 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.74A 2eilC-4d0oA:
3.6
2eilJ-4d0oA:
undetectable
2eilC-4d0oA:
17.79
2eilJ-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 8 TYR A2114
SER A2025
GLN A2107
ILE A2143
None
1.13A 2xz5B-4d0oA:
undetectable
2xz5E-4d0oA:
undetectable
2xz5B-4d0oA:
20.00
2xz5E-4d0oA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 6 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.76A 3ablP-4d0oA:
3.5
3ablW-4d0oA:
undetectable
3ablP-4d0oA:
17.79
3ablW-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 7 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.70A 3ag2C-4d0oA:
3.3
3ag2C-4d0oA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 7 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.62A 3ag2P-4d0oA:
3.5
3ag2W-4d0oA:
undetectable
3ag2P-4d0oA:
17.79
3ag2W-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 7 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.74A 3asnC-4d0oA:
3.5
3asnJ-4d0oA:
undetectable
3asnC-4d0oA:
17.79
3asnJ-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
3 / 3 CYH A2105
HIS A2108
PHE A2104
None
1.13A 3cr4X-4d0oA:
1.1
3cr4X-4d0oA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
5 / 12 HIS A2053
LEU A2006
ILE A2003
LEU A2097
TYR A2101
None
1.47A 3gwxB-4d0oA:
undetectable
3gwxB-4d0oA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 8 GLY A2027
ILE A2019
CYH A2146
PHE A2104
None
1.04A 3ko0B-4d0oA:
1.0
3ko0J-4d0oA:
0.9
3ko0B-4d0oA:
19.42
3ko0J-4d0oA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 8 TYR A2157
GLU A2010
TYR A2101
LEU A2097
None
1.10A 3rqwC-4d0oA:
2.6
3rqwD-4d0oA:
2.6
3rqwC-4d0oA:
21.41
3rqwD-4d0oA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 8 GLU A2010
TYR A2101
LEU A2097
TYR A2157
None
1.10A 3rqwF-4d0oA:
2.7
3rqwJ-4d0oA:
undetectable
3rqwF-4d0oA:
21.41
3rqwJ-4d0oA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 7 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.61A 3x2qC-4d0oA:
3.6
3x2qJ-4d0oA:
undetectable
3x2qC-4d0oA:
17.79
3x2qJ-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 7 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.62A 3x2qP-4d0oA:
3.5
3x2qW-4d0oA:
undetectable
3x2qP-4d0oA:
17.79
3x2qW-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 8 SER A2067
ILE A2078
ILE A2060
ASP A2083
None
0.84A 4dtaB-4d0oA:
undetectable
4dtaB-4d0oA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 6 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.82A 5b1bC-4d0oA:
3.6
5b1bJ-4d0oA:
undetectable
5b1bC-4d0oA:
17.79
5b1bJ-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 7 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.72A 5b1bP-4d0oA:
3.6
5b1bW-4d0oA:
undetectable
5b1bP-4d0oA:
17.79
5b1bW-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 4 LEU A2006
ARG A1999
ILE A2003
ILE A2078
None
1.41A 5dzk2-4d0oA:
undetectable
5dzkM-4d0oA:
undetectable
5dzkN-4d0oA:
undetectable
5dzk2-4d0oA:
3.03
5dzkM-4d0oA:
21.62
5dzkN-4d0oA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 6 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.55A 5z84P-4d0oA:
3.5
5z84W-4d0oA:
undetectable
5z84P-4d0oA:
17.79
5z84W-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 7 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.59A 5z85C-4d0oA:
3.6
5z85J-4d0oA:
undetectable
5z85C-4d0oA:
17.79
5z85J-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 6 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.53A 5z85P-4d0oA:
3.5
5z85W-4d0oA:
undetectable
5z85P-4d0oA:
17.79
5z85W-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 6 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.57A 5z86C-4d0oA:
3.6
5z86J-4d0oA:
undetectable
5z86C-4d0oA:
17.79
5z86J-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 6 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.55A 5z86P-4d0oA:
3.6
5z86W-4d0oA:
undetectable
5z86P-4d0oA:
17.79
5z86W-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 6 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.67A 5zcoP-4d0oA:
3.5
5zcoW-4d0oA:
undetectable
5zcoP-4d0oA:
17.79
5zcoW-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 6 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.63A 5zcpC-4d0oA:
3.6
5zcpJ-4d0oA:
undetectable
5zcpC-4d0oA:
17.79
5zcpJ-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 6 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.62A 5zcpP-4d0oA:
3.5
5zcpW-4d0oA:
undetectable
5zcpP-4d0oA:
17.79
5zcpW-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 7 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.65A 5zcqC-4d0oA:
3.6
5zcqJ-4d0oA:
undetectable
5zcqC-4d0oA:
17.79
5zcqJ-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo
sapiens)
4 / 7 GLN A2008
PHE A2011
PHE A2057
LEU A2061
None
0.51A 5zcqP-4d0oA:
3.5
5zcqW-4d0oA:
undetectable
5zcqP-4d0oA:
17.79
5zcqW-4d0oA:
13.75