SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d0p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 4d0p COP9 SIGNALOSOME
COMPLEX SUBUNIT 4
(Homo
sapiens) 		4 / 8 ILE A 272
LEU A 327
LEU A 315
LEU A 324
 None
 0.85A 1eupA-4d0pA:
undetectable		 1eupA-4d0pA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 4d0p COP9 SIGNALOSOME
COMPLEX SUBUNIT 4
(Homo
sapiens) 		4 / 8 SER A 172
ALA A 164
ARG A 198
LEU A 156
 None
 0.95A 2bxkA-4d0pA:
2.4		 2bxkA-4d0pA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4d0p COP9 SIGNALOSOME
COMPLEX SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR A 233
ASP A 270
SER A 313
 None
 0.79A 2nxeA-4d0pA:
undetectable		 2nxeA-4d0pA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4d0p COP9 SIGNALOSOME
COMPLEX SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR A 233
ASP A 270
SER A 313
 None
 0.84A 2nxeB-4d0pA:
undetectable		 2nxeB-4d0pA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 4d0p COP9 SIGNALOSOME
COMPLEX SUBUNIT 4
(Homo
sapiens) 		4 / 6 GLN A 289
ALA A 225
ALA A 229
THR A 233
 None
 0.86A 2xfhA-4d0pA:
undetectable		 2xfhA-4d0pA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 4d0p COP9 SIGNALOSOME
COMPLEX SUBUNIT 4
(Homo
sapiens) 		4 / 8 LYS A 290
ILE A 299
LEU A 235
ASP A 196
 None
 0.96A 4dtaB-4d0pA:
undetectable		 4dtaB-4d0pA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4d0p COP9 SIGNALOSOME
COMPLEX SUBUNIT 4
(Homo
sapiens) 		3 / 3 LYS A 188
TYR A 191
ARG A 207
 None
 1.31A 4gc9A-4d0pA:
undetectable		 4gc9A-4d0pA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4d0p COP9 SIGNALOSOME
COMPLEX SUBUNIT 4
(Homo
sapiens) 		5 / 12 PHE A 321
GLY A 325
ALA A 326
SER A 340
GLN A 354
 None
None
None
NA  A 509 (-2.2A)
None
 1.27A 4rtpA-4d0pA:
undetectable		 4rtpA-4d0pA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4d0p COP9 SIGNALOSOME
COMPLEX SUBUNIT 4
(Homo
sapiens) 		3 / 3 SER A 178
GLU A 133
GLU A 100
 None
 0.82A 4ymgB-4d0pA:
undetectable		 4ymgB-4d0pA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 4d0p COP9 SIGNALOSOME
COMPLEX SUBUNIT 4
(Homo
sapiens) 		4 / 8 ASP A 119
ASN A 122
ALA A 123
VAL A 126
 None
 0.80A 4zbqA-4d0pA:
undetectable		 4zbqA-4d0pA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4d0p COP9 SIGNALOSOME
COMPLEX SUBUNIT 4
(Homo
sapiens) 		3 / 3 ARG A 242
LEU A 246
PHE A 250
 None
 0.73A 6nknP-4d0pA:
1.8		 6nknP-4d0pA:
19.95