SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d0q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 4d0q HYALURONATE LYASE
(Streptococcus
pneumoniae) 		3 / 3 ALA A 114
VAL A  83
TRP A  82
 None
 0.81A 1nt5A-4d0qA:
undetectable		 1nt5A-4d0qA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 4d0q HYALURONATE LYASE
(Streptococcus
pneumoniae) 		3 / 3 ALA A 114
VAL A  83
TRP A  82
 None
 0.81A 1nt5B-4d0qA:
undetectable		 1nt5B-4d0qA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 4d0q HYALURONATE LYASE
(Streptococcus
pneumoniae) 		4 / 6 LEU A 188
LEU A 115
ILE A 202
ARG A 117
 None
 0.97A 2rlfC-4d0qA:
undetectable
2rlfD-4d0qA:
undetectable		 2rlfC-4d0qA:
16.17
2rlfD-4d0qA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 4d0q HYALURONATE LYASE
(Streptococcus
pneumoniae) 		4 / 7 SER A 159
PHE A 199
ILE A 171
GLY A 140
 None
 0.75A 2v0mC-4d0qA:
undetectable		 2v0mC-4d0qA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4d0q HYALURONATE LYASE
(Streptococcus
pneumoniae) 		5 / 12 PHE A 199
ILE A 103
ASP A 100
GLY A 101
PHE A  61
 None
 1.29A 4eb4A-4d0qA:
undetectable		 4eb4A-4d0qA:
20.38