SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 6
COP9 SIGNALOSOME
COMPLEX SUBUNIT 8
(Homo
sapiens) 		4 / 8 LEU H 200
VAL F 286
CYH F 283
GLY F 287
 None
 0.94A 1jlfA-4d10H:
undetectable
1jlfB-4d10H:
undetectable		 1jlfA-4d10H:
19.03
1jlfB-4d10H:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
(Homo
sapiens) 		6 / 12 LEU C  39
GLY C  57
SER C  31
LEU C  59
LEU C  56
LEU C  62
 None
 1.47A 1mx1D-4d10C:
undetectable		 1mx1D-4d10C:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
(Homo
sapiens) 		6 / 11 ALA C 127
ASP C 129
GLY C 122
ILE C 121
VAL C  81
ILE C  85
 None
 1.24A 1ohrA-4d10C:
undetectable		 1ohrA-4d10C:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 6
(Homo
sapiens) 		5 / 12 LEU F 150
LEU F 152
MET F  84
GLN F  76
ILE F 146
 None
 1.28A 1p93A-4d10F:
undetectable		 1p93A-4d10F:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 6
(Homo
sapiens) 		4 / 7 PHE F 183
GLY F 123
VAL F 138
ASP F 135
 None
 0.98A 1t88A-4d10F:
undetectable		 1t88A-4d10F:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
(Homo
sapiens) 		5 / 11 ALA C 127
ASP C 129
GLY C 122
VAL C  81
ILE C  85
 None
 1.04A 2qhcA-4d10C:
undetectable		 2qhcA-4d10C:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
(Homo
sapiens) 		5 / 9 LEU C 107
ILE C 141
ALA C 127
GLY C  57
LEU C  56
 None
 1.23A 2v0mB-4d10C:
undetectable		 2v0mB-4d10C:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 6
(Homo
sapiens) 		4 / 6 GLN F 111
PHE F 112
PHE F  87
LEU F  89
 None
 1.15A 3ablP-4d10F:
undetectable
3ablW-4d10F:
3.3		 3ablP-4d10F:
21.26
3ablW-4d10F:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 6
(Homo
sapiens) 		4 / 8 LEU F  72
ALA F  42
LEU F  43
ILE F 146
 None
 0.89A 3cldB-4d10F:
undetectable		 3cldB-4d10F:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
(Homo
sapiens) 		6 / 12 ALA C 127
ASP C 129
GLY C 122
ILE C 121
VAL C  81
ILE C  85
 None
 1.34A 3d1xA-4d10C:
undetectable		 3d1xA-4d10C:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
(Homo
sapiens) 		6 / 12 ALA C 127
ASP C 129
GLY C 122
ILE C 121
VAL C  81
ILE C  85
 None
 1.32A 3d1yA-4d10C:
undetectable		 3d1yA-4d10C:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 8
(Homo
sapiens) 		4 / 5 ARG H 116
ILE H  89
TYR H  90
THR H  91
 None
 1.39A 3dgqA-4d10H:
undetectable		 3dgqA-4d10H:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
(Homo
sapiens) 		6 / 12 ALA C 127
ASP C 129
GLY C 122
ILE C 121
VAL C  81
ILE C  85
 None
 1.32A 3el1B-4d10C:
undetectable		 3el1B-4d10C:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
(Homo
sapiens) 		5 / 9 ALA C 127
ASP C 129
GLY C 122
VAL C  81
ILE C  85
 None
 1.02A 3em4B-4d10C:
undetectable		 3em4B-4d10C:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
(Homo
sapiens) 		3 / 3 SER C  55
ASP C  43
ASP C  50
 None
 0.84A 3iv6A-4d10C:
undetectable		 3iv6A-4d10C:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
(Homo
sapiens) 		3 / 3 SER C  55
ASP C  43
ASP C  50
 None
 0.87A 3iv6C-4d10C:
undetectable		 3iv6C-4d10C:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 8
(Homo
sapiens) 		4 / 8 GLU H 107
PHE H  13
ARG H 110
ASP H 111
 None
 1.08A 3mjrD-4d10H:
undetectable		 3mjrD-4d10H:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
(Homo
sapiens) 		6 / 9 ALA C 127
ASP C 129
GLY C 122
ILE C 121
VAL C  81
ILE C  85
 None
 1.30A 3ndwB-4d10C:
undetectable		 3ndwB-4d10C:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
(Homo
sapiens) 		6 / 11 ALA C 127
ASP C 129
GLY C 122
ILE C 121
VAL C  81
ILE C  85
 None
 1.30A 3ndxB-4d10C:
undetectable		 3ndxB-4d10C:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
(Homo
sapiens) 		5 / 11 ALA C 127
ASP C 129
GLY C 122
VAL C  81
ILE C  85
 None
 1.02A 3oxxD-4d10C:
undetectable		 3oxxD-4d10C:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
COP9 SIGNALOSOME
COMPLEX SUBUNIT 8
(Homo
sapiens;
Homo
sapiens) 		4 / 5 GLU H  26
LEU H  25
GLN C 126
GLY C 122
 None
 1.13A 3pp1A-4d10H:
undetectable		 3pp1A-4d10H:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 6
(Homo
sapiens) 		5 / 12 GLU F 120
VAL F  39
ILE F  81
ILE F 146
GLU F 147
 None
 1.29A 4a99A-4d10F:
undetectable
4a99C-4d10F:
undetectable		 4a99A-4d10F:
19.53
4a99C-4d10F:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
(Homo
sapiens) 		4 / 8 TYR C 176
CYH C 146
TYR C 184
ILE C 128
 None
 1.32A 4bqtC-4d10C:
undetectable
4bqtD-4d10C:
undetectable		 4bqtC-4d10C:
19.39
4bqtD-4d10C:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 8
(Homo
sapiens) 		4 / 8 ASN H  22
GLU H  21
GLU H  24
TYR H  55
 None
 1.11A 4mj8A-4d10H:
undetectable
4mj8C-4d10H:
undetectable		 4mj8A-4d10H:
20.98
4mj8C-4d10H:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
(Homo
sapiens) 		3 / 3 GLN C 132
TYR C 161
ASN C 136
 None
 0.97A 6dwdC-4d10C:
undetectable		 6dwdC-4d10C:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
(Homo
sapiens) 		3 / 3 LEU C  77
GLN C  80
LYS C  65
 None
 0.91A 6exiB-4d10C:
undetectable		 6exiB-4d10C:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
(Homo
sapiens) 		3 / 3 LEU C  77
GLN C  80
LYS C  65
 None
 0.94A 6exiA-4d10C:
undetectable		 6exiA-4d10C:
11.51