SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d1e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		5 / 12 GLY A 534
ALA A 535
ASP A 538
VAL A 618
VAL A 614
 None
 0.96A 1k6cB-4d1eA:
undetectable		 1k6cB-4d1eA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		4 / 8 LEU A 186
GLY A 183
LEU A 229
PRO A 240
 None
MLZ  A 181 ( 4.3A)
None
MLZ  A 239 ( 2.6A)
 0.95A 1ya4A-4d1eA:
undetectable		 1ya4A-4d1eA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		4 / 7 LEU A 186
GLY A 183
LEU A 229
PRO A 240
 None
MLZ  A 181 ( 4.3A)
None
MLZ  A 239 ( 2.6A)
 0.90A 1ya4B-4d1eA:
undetectable		 1ya4B-4d1eA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		4 / 6 LEU A 565
ALA A 535
HIS A 558
ASP A 622
 MLZ  A 562 ( 4.2A)
None
MLZ  A 562 ( 4.1A)
MLZ  A 562 ( 3.8A)
 1.34A 2dpzA-4d1eA:
undetectable		 2dpzA-4d1eA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		5 / 12 GLY A 185
ASN A 170
ILE A 245
GLN A  39
ASN A 211
 None
 1.13A 3eeyA-4d1eA:
undetectable		 3eeyA-4d1eA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		5 / 12 GLY A 185
ASN A 170
ILE A 245
GLN A  39
ASN A 211
 None
 1.13A 3eeyF-4d1eA:
undetectable		 3eeyF-4d1eA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		5 / 12 GLY A 185
ASN A 170
ILE A 245
GLN A  39
ASN A 211
 None
 1.14A 3eeyH-4d1eA:
undetectable		 3eeyH-4d1eA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		5 / 12 GLY A 185
ASN A 170
ILE A 245
GLN A  39
ASN A 211
 None
 1.11A 3eeyI-4d1eA:
undetectable		 3eeyI-4d1eA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		5 / 12 THR A 495
THR A 497
GLU A 502
LEU A 425
LEU A 451
 None
 1.45A 3gwxB-4d1eA:
undetectable		 3gwxB-4d1eA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		4 / 5 HIS A 633
GLN A 552
SER A 547
VAL A 545
 None
 1.41A 4a99D-4d1eA:
undetectable		 4a99D-4d1eA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		3 / 3 LYS A 205
LYS A 182
PRO A 208
 None
MLZ  A 181 ( 3.1A)
MLZ  A 181 ( 4.8A)
 1.26A 4dv1L-4d1eA:
undetectable		 4dv1L-4d1eA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		5 / 12 LEU A 396
LEU A 399
LEU A 402
ALA A 403
ALA A 476
 None
 0.97A 4fn9A-4d1eA:
undetectable		 4fn9A-4d1eA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		4 / 8 LEU A 726
GLY A 723
GLU A 725
GLU A 718
 None
 0.75A 4rjdA-4d1eA:
1.6
4rjdB-4d1eA:
1.3		 4rjdA-4d1eA:
6.74
4rjdB-4d1eA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		5 / 12 GLY A 183
SER A 179
ALA A 188
ASN A 170
TYR A 200
 MLZ  A 181 ( 4.3A)
None
None
None
None
 1.22A 4ymgA-4d1eA:
undetectable		 4ymgA-4d1eA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		5 / 12 GLY A 183
SER A 179
ALA A 188
ASN A 170
TYR A 200
 MLZ  A 181 ( 4.3A)
None
None
None
None
 1.23A 4ymgB-4d1eA:
undetectable		 4ymgB-4d1eA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		4 / 7 PRO A 240
ILE A 245
LEU A 186
MET A 216
 MLZ  A 239 ( 2.6A)
None
None
None
 1.05A 5fxtA-4d1eA:
undetectable		 5fxtA-4d1eA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		4 / 6 LEU A  74
CYH A  48
HIS A  51
LEU A  52
 MLZ  A  71 ( 4.2A)
None
None
None
 1.07A 5hpuC-4d1eA:
undetectable
5hpuD-4d1eA:
undetectable		 5hpuC-4d1eA:
2.83
5hpuD-4d1eA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		4 / 5 LEU A  52
VAL A  78
GLU A  77
LEU A  74
 None
None
None
MLZ  A  71 ( 4.2A)
 0.98A 5xooB-4d1eA:
undetectable		 5xooB-4d1eA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4d1e ALPHA-ACTININ-2
(Homo
sapiens) 		5 / 12 VAL A 614
LEU A 565
PHE A 561
GLY A 534
PHE A 528
 None
MLZ  A 562 ( 4.2A)
MLZ  A 562 ( 4.5A)
None
None
 1.12A 6drzA-4d1eA:
3.2		 6drzA-4d1eA:
18.17