SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d1y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4d1y PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		4 / 5 ASP A  92
GLY A  62
VAL A  56
ILE A  57
 None
 0.81A 2aoiA-4d1yA:
undetectable		 2aoiA-4d1yA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 4d1y PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		5 / 11 ILE A 138
ALA A 129
PHE A 154
ILE A  97
THR A 144
 None
 1.17A 2w3aA-4d1yA:
undetectable		 2w3aA-4d1yA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 4d1y PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		5 / 10 ILE A 138
ALA A 129
PHE A 154
ILE A  97
THR A 144
 None
 1.26A 2w3aB-4d1yA:
undetectable		 2w3aB-4d1yA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4d1y PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		4 / 7 GLU A  42
ALA A   9
ASN A  11
ALA A  36
 None
 0.88A 2zgwA-4d1yA:
undetectable		 2zgwA-4d1yA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4d1y PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		4 / 6 GLU A  42
ALA A   9
ASN A  11
ALA A  36
 None
 0.83A 2zgwB-4d1yA:
undetectable		 2zgwB-4d1yA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4d1y PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		5 / 12 MET A  94
PHE A 119
ILE A  97
PHE A  81
LEU A 133
 None
 1.47A 3aocC-4d1yA:
undetectable		 3aocC-4d1yA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 4d1y PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		5 / 9 ASN A  14
GLY A  15
GLY A  17
ASN A 161
SER A  47
 None
None
None
RBF  A1176 (-4.2A)
None
 1.14A 3ztvA-4d1yA:
undetectable		 3ztvA-4d1yA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 4d1y PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		5 / 9 VAL A  78
ILE A 122
THR A 156
VAL A 130
ALA A 112
 None
None
None
None
ZN  A1177 ( 4.4A)
 1.16A 4oqrA-4d1yA:
undetectable		 4oqrA-4d1yA:
18.34