SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 4d25 BMVLG PROTEIN
(Bombyx
mori) 		3 / 3 ASP A 338
HIS A 517
ASP A 341
 MG  A1565 ( 3.7A)
None
None
 0.84A 1nw5A-4d25A:
2.4		 1nw5A-4d25A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4d25 BMVLG PROTEIN
(Bombyx
mori) 		3 / 3 LEU A 508
PRO A 509
LEU A 543
 None
 0.53A 2po7B-4d25A:
4.0		 2po7B-4d25A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4d25 BMVLG PROTEIN
(Bombyx
mori) 		3 / 3 LEU A 508
PRO A 509
LEU A 543
 None
 0.47A 2qd5B-4d25A:
3.4		 2qd5B-4d25A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 4d25 BMVLG PROTEIN
(Bombyx
mori) 		4 / 5 ARG A 493
ASP A 341
ILE A 380
GLU A 514
 None
 1.45A 2xrzA-4d25A:
undetectable
2xrzB-4d25A:
undetectable		 2xrzA-4d25A:
20.56
2xrzB-4d25A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4d25 BMVLG PROTEIN
(Bombyx
mori) 		3 / 3 LEU A 508
PRO A 509
LEU A 543
 None
 0.56A 3hcrA-4d25A:
2.4		 3hcrA-4d25A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4d25 BMVLG PROTEIN
(Bombyx
mori) 		5 / 11 GLU A 276
GLY A 229
ALA A 232
ILE A 206
ALA A 224
 ANP  A1564 ( 4.5A)
ANP  A1564 (-3.5A)
ANP  A1564 ( 4.6A)
None
None
 1.17A 3nmuB-4d25A:
undetectable
3nmuJ-4d25A:
3.2		 3nmuB-4d25A:
22.93
3nmuJ-4d25A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4d25 BMVLG PROTEIN
(Bombyx
mori) 		4 / 5 LEU A 344
LEU A 337
MET A 355
THR A 369
 None
 1.22A 4do3A-4d25A:
undetectable		 4do3A-4d25A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4d25 BMVLG PROTEIN
(Bombyx
mori) 		3 / 3 LEU A 474
ILE A 461
ARG A 470
 None
None
C  D   4 ( 3.0A)
 0.71A 4mk4B-4d25A:
3.4		 4mk4B-4d25A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 4d25 BMVLG PROTEIN
(Bombyx
mori) 		3 / 3 GLU A 276
ALA A 277
PHE A 280
 ANP  A1564 ( 4.5A)
None
None
 0.24A 4v1fA-4d25A:
undetectable		 4v1fA-4d25A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 4d25 BMVLG PROTEIN
(Bombyx
mori) 		3 / 3 GLU A 276
ALA A 277
PHE A 280
 ANP  A1564 ( 4.5A)
None
None
 0.28A 4v1fC-4d25A:
undetectable		 4v1fC-4d25A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4d25 BMVLG PROTEIN
(Bombyx
mori) 		5 / 12 GLY A 401
GLY A 400
THR A 375
ILE A 512
ILE A 519
 None
 1.27A 4zvmA-4d25A:
undetectable
4zvmB-4d25A:
2.2		 4zvmA-4d25A:
18.85
4zvmB-4d25A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4d25 BMVLG PROTEIN
(Bombyx
mori) 		3 / 3 ARG A 524
HIS A 517
ARG A 521
 ANP  A1564 (-2.9A)
None
ANP  A1564 (-2.5A)
 1.10A 5iaoC-4d25A:
3.2		 5iaoC-4d25A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 4d25 BMVLG PROTEIN
(Bombyx
mori) 		4 / 8 GLY A 523
ILE A 154
GLN A 272
ASP A 501
 None
ANP  A1564 (-4.2A)
None
None
 0.80A 5vlmH-4d25A:
undetectable		 5vlmH-4d25A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4d25 BMVLG PROTEIN
(Bombyx
mori) 		5 / 11 ARG A 324
GLY A 316
GLY A 294
GLN A 300
THR A 270
 U  D   6 ( 4.1A)
A  D   5 ( 3.1A)
U  D   6 ( 3.9A)
None
None
 1.26A 5x1fG-4d25A:
undetectable
5x1fN-4d25A:
undetectable
5x1fO-4d25A:
undetectable		 5x1fG-4d25A:
11.78
5x1fN-4d25A:
18.83
5x1fO-4d25A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 4d25 BMVLG PROTEIN
(Bombyx
mori) 		4 / 6 GLY A 400
SER A 373
THR A 226
VAL A 516
 None
None
ANP  A1564 (-4.5A)
None
 1.21A 5ysiA-4d25A:
undetectable		 5ysiA-4d25A:
16.40