SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d2j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		4 / 4 THR A 277
LEU A 281
VAL A 284
LEU A 288
 None
 0.51A 1fbmB-4d2jA:
undetectable		 1fbmB-4d2jA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		4 / 4 THR A 277
LEU A 281
VAL A 284
LEU A 288
 None
 0.68A 1fbmD-4d2jA:
undetectable		 1fbmD-4d2jA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		4 / 4 THR A 277
LEU A 281
VAL A 284
LEU A 288
 None
 0.71A 1mz9D-4d2jA:
undetectable		 1mz9D-4d2jA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		4 / 7 PHE A 134
ALA A 103
ILE A 110
GLU A 105
 None
 0.74A 1oniA-4d2jA:
undetectable
1oniB-4d2jA:
undetectable		 1oniA-4d2jA:
17.75
1oniB-4d2jA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		4 / 7 PHE A 134
ALA A 103
ILE A 110
GLU A 105
 None
 0.70A 1oniD-4d2jA:
undetectable
1oniF-4d2jA:
undetectable		 1oniD-4d2jA:
17.75
1oniF-4d2jA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		4 / 7 ILE A 110
GLU A 105
PHE A 134
ALA A 103
 None
 1.00A 1oniD-4d2jA:
undetectable
1oniE-4d2jA:
undetectable		 1oniD-4d2jA:
17.75
1oniE-4d2jA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		4 / 7 ILE A 110
GLU A 105
PHE A 134
ALA A 103
 None
 0.83A 1oniG-4d2jA:
undetectable
1oniI-4d2jA:
undetectable		 1oniG-4d2jA:
17.75
1oniI-4d2jA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 12 LEU A 328
THR A 306
ILE A 320
SER A 343
PHE A 341
 None
None
None
SO4  A1418 ( 3.9A)
None
 1.47A 1xoqB-4d2jA:
undetectable		 1xoqB-4d2jA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 12 LEU A 139
LEU A 398
SER A 144
GLY A  99
ARG A 403
 None
 1.35A 2vmyB-4d2jA:
undetectable		 2vmyB-4d2jA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 12 GLY A 297
GLN A 250
VAL A 255
LEU A 288
ILE A  93
 None
 1.25A 3h52B-4d2jA:
undetectable		 3h52B-4d2jA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 12 GLY A 345
LEU A 342
GLU A 348
ALA A 351
ASN A 354
 None
 1.14A 3kkzA-4d2jA:
undetectable		 3kkzA-4d2jA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 12 VAL A 258
LEU A 300
VAL A 238
GLY A 241
LEU A 288
 None
 1.06A 3ln1B-4d2jA:
undetectable		 3ln1B-4d2jA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 12 VAL A 258
LEU A 300
VAL A 238
GLY A 241
LEU A 288
 None
 1.06A 3ln1C-4d2jA:
undetectable		 3ln1C-4d2jA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 12 VAL A 258
LEU A 300
VAL A 238
GLY A 241
LEU A 288
 None
 1.06A 3ln1D-4d2jA:
undetectable		 3ln1D-4d2jA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 12 VAL A 258
LEU A 300
VAL A 238
GLY A 241
LEU A 288
 None
 1.00A 3nt1A-4d2jA:
undetectable		 3nt1A-4d2jA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 12 VAL A 258
LEU A 300
VAL A 238
GLY A 241
LEU A 288
 None
 0.99A 3nt1B-4d2jA:
undetectable		 3nt1B-4d2jA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 12 VAL A 258
LEU A 300
VAL A 238
GLY A 241
LEU A 288
 None
 1.05A 3pghD-4d2jA:
undetectable		 3pghD-4d2jA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		4 / 4 GLY A 140
GLY A 138
THR A 136
LEU A 398
 None
 0.93A 3si7C-4d2jA:
undetectable
3si7D-4d2jA:
undetectable		 3si7C-4d2jA:
22.19
3si7D-4d2jA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 12 LEU A 133
GLY A 373
GLU A 105
GLN A 377
ALA A 146
 None
SO4  A1418 (-3.4A)
None
None
None
 1.03A 3tbgB-4d2jA:
undetectable		 3tbgB-4d2jA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 12 LEU A 133
GLY A 373
GLU A 105
GLN A 377
ALA A 146
 None
SO4  A1418 (-3.4A)
None
None
None
 1.05A 3tbgD-4d2jA:
undetectable		 3tbgD-4d2jA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 12 PHE A 134
VAL A 164
PRO A 174
SER A 371
GLY A  99
 None
 1.42A 4hvcA-4d2jA:
undetectable		 4hvcA-4d2jA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		4 / 7 THR A 331
LEU A 221
ASN A 303
LEU A 342
 None
 1.04A 4ib4A-4d2jA:
undetectable		 4ib4A-4d2jA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 12 PHE A 134
VAL A 164
PRO A 174
SER A 371
GLY A  99
 None
 1.49A 4olfA-4d2jA:
undetectable		 4olfA-4d2jA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 11 LEU A 133
GLY A 373
GLU A 105
GLN A 377
ALA A 146
 None
SO4  A1418 (-3.4A)
None
None
None
 1.08A 4wnuA-4d2jA:
undetectable		 4wnuA-4d2jA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 11 LEU A 133
GLY A 373
GLU A 105
GLN A 377
ALA A 146
 None
SO4  A1418 (-3.4A)
None
None
None
 1.07A 4wnuC-4d2jA:
undetectable		 4wnuC-4d2jA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		4 / 6 LEU A 294
ALA A 298
LEU A  86
VAL A 258
 None
 1.29A 5a6iA-4d2jA:
undetectable		 5a6iA-4d2jA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		4 / 8 ASN A 303
PRO A 302
PHE A 341
SER A 343
 None
None
None
SO4  A1418 ( 3.9A)
 1.39A 5amiB-4d2jA:
undetectable		 5amiB-4d2jA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 12 PHE A 285
VAL A 284
PRO A 260
PHE A 341
GLY A 344
 None
 1.31A 5f9zB-4d2jA:
undetectable		 5f9zB-4d2jA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 12 VAL A 258
LEU A 300
VAL A 238
GLY A 241
LEU A 288
 None
 1.02A 5jvzA-4d2jA:
undetectable		 5jvzA-4d2jA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 12 VAL A 258
LEU A 300
VAL A 238
GLY A 241
LEU A 288
 None
 1.05A 5jw1A-4d2jA:
undetectable		 5jw1A-4d2jA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		4 / 4 ARG A 401
SER A 347
ASP A 350
HIS A 317
 None
 1.49A 5zhmA-4d2jA:
0.2		 5zhmA-4d2jA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Toxoplasma
gondii) 		5 / 12 VAL A 305
ARG A 374
ILE A 147
LEU A 101
GLY A  99
 None
SO4  A1418 (-4.1A)
None
None
None
 0.97A 6c2mA-4d2jA:
undetectable		 6c2mA-4d2jA:
12.07