SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d3d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4d3d IMINE REDUCTASE
(Bacillus
cereus) 		4 / 8 SER A 112
ASN A 110
ASP A 114
LYS A 118
 None
 1.25A 1hwiB-4d3dA:
undetectable		 1hwiB-4d3dA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 4d3d IMINE REDUCTASE
(Bacillus
cereus) 		4 / 7 SER A 112
ASN A 110
ASP A 114
LYS A 118
 None
 1.25A 1hwiC-4d3dA:
undetectable		 1hwiC-4d3dA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 4d3d IMINE REDUCTASE
(Bacillus
cereus) 		4 / 7 SER A 112
ASN A 110
ASP A 114
LYS A 118
 None
 1.25A 1hwiD-4d3dA:
undetectable		 1hwiD-4d3dA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4d3d IMINE REDUCTASE
(Bacillus
cereus) 		4 / 8 SER A 112
ASN A 110
ASP A 114
LYS A 118
 None
 1.27A 1hwkA-4d3dA:
undetectable		 1hwkA-4d3dA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4d3d IMINE REDUCTASE
(Bacillus
cereus) 		4 / 8 SER A 112
ASN A 110
ASP A 114
LYS A 118
 None
 1.26A 1hwkC-4d3dA:
undetectable		 1hwkC-4d3dA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 4d3d IMINE REDUCTASE
(Bacillus
cereus) 		4 / 5 LEU A 168
ILE A  83
LEU A  84
SER A  85
 None
 0.79A 2byoA-4d3dA:
undetectable		 2byoA-4d3dA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 4d3d IMINE REDUCTASE
(Bacillus
cereus) 		4 / 8 LEU A  84
ALA A 123
LEU A 126
TYR A 154
 None
 0.84A 3cldB-4d3dA:
undetectable		 3cldB-4d3dA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 4d3d IMINE REDUCTASE
(Bacillus
cereus) 		4 / 5 ASN A  90
ASN A 110
HIS A 133
ALA A 122
 None
 1.27A 3frqA-4d3dA:
undetectable		 3frqA-4d3dA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 4d3d IMINE REDUCTASE
(Bacillus
cereus) 		4 / 7 ASN A  90
ASN A 110
HIS A 133
ALA A 122
 None
 1.27A 3frqB-4d3dA:
undetectable		 3frqB-4d3dA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 4d3d IMINE REDUCTASE
(Bacillus
cereus) 		5 / 12 GLY A  34
GLY A  31
VAL A  82
VAL A  99
LEU A  96
 None
 1.00A 3m6wA-4d3dA:
3.5		 3m6wA-4d3dA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 4d3d IMINE REDUCTASE
(Bacillus
cereus) 		4 / 5 ILE A 145
SER A 148
LYS A 147
GLY A 146
 None
 1.17A 3tkdB-4d3dA:
undetectable		 3tkdB-4d3dA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 4d3d IMINE REDUCTASE
(Bacillus
cereus) 		4 / 5 ILE A 145
SER A 148
LYS A 147
GLY A 146
 None
 1.16A 3tkdA-4d3dA:
undetectable		 3tkdA-4d3dA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4d3d IMINE REDUCTASE
(Bacillus
cereus) 		5 / 12 GLY A  29
GLY A  31
PRO A  32
LEU A  86
VAL A  91
 MG  A1306 ( 4.1A)
None
None
None
None
 0.70A 4gc9A-4d3dA:
3.4		 4gc9A-4d3dA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 4d3d IMINE REDUCTASE
(Bacillus
cereus) 		3 / 3 TRP A  51
ARG A  53
LEU A  84
 None
 0.83A 5dbyA-4d3dA:
undetectable		 5dbyA-4d3dA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 4d3d IMINE REDUCTASE
(Bacillus
cereus) 		5 / 9 PRO A  98
VAL A  82
LEU A  84
ILE A  28
TYR A  93
 None
 1.48A 5iepA-4d3dA:
undetectable		 5iepA-4d3dA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4d3d IMINE REDUCTASE
(Bacillus
cereus) 		3 / 3 SER A 155
TYR A 154
TYR A 176
 None
 0.76A 5lakA-4d3dA:
undetectable
5lakI-4d3dA:
undetectable		 5lakA-4d3dA:
21.18
5lakI-4d3dA:
2.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4d3d IMINE REDUCTASE
(Bacillus
cereus) 		3 / 3 SER A 155
TYR A 154
TYR A 176
 None
 0.77A 5lakC-4d3dA:
undetectable
5lakJ-4d3dA:
undetectable		 5lakC-4d3dA:
21.18
5lakJ-4d3dA:
2.13