SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.41A 1v54A-4d3sA:
undetectable
1v54C-4d3sA:
undetectable		 1v54A-4d3sA:
21.50
1v54C-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.41A 1v54N-4d3sA:
undetectable
1v54P-4d3sA:
undetectable		 1v54N-4d3sA:
21.50
1v54P-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.39A 1v55A-4d3sA:
undetectable
1v55C-4d3sA:
undetectable		 1v55A-4d3sA:
21.50
1v55C-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.40A 2dyrA-4d3sA:
undetectable
2dyrC-4d3sA:
undetectable		 2dyrA-4d3sA:
21.50
2dyrC-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.40A 2dyrN-4d3sA:
undetectable
2dyrP-4d3sA:
undetectable		 2dyrN-4d3sA:
21.50
2dyrP-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.40A 2eijA-4d3sA:
undetectable
2eijC-4d3sA:
undetectable		 2eijA-4d3sA:
21.50
2eijC-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.39A 2eijN-4d3sA:
undetectable
2eijP-4d3sA:
undetectable		 2eijN-4d3sA:
21.50
2eijP-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.39A 2eikA-4d3sA:
undetectable
2eikC-4d3sA:
undetectable		 2eikA-4d3sA:
21.50
2eikC-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.40A 2eikN-4d3sA:
undetectable
2eikP-4d3sA:
undetectable		 2eikN-4d3sA:
21.50
2eikP-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.42A 2eilA-4d3sA:
undetectable
2eilC-4d3sA:
undetectable		 2eilA-4d3sA:
21.50
2eilC-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.41A 2eilN-4d3sA:
undetectable
2eilP-4d3sA:
undetectable		 2eilN-4d3sA:
21.50
2eilP-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.41A 2y69A-4d3sA:
undetectable
2y69C-4d3sA:
undetectable		 2y69A-4d3sA:
21.50
2y69C-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.40A 3abkA-4d3sA:
undetectable
3abkC-4d3sA:
undetectable		 3abkA-4d3sA:
21.50
3abkC-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.38A 3abkN-4d3sA:
undetectable
3abkP-4d3sA:
undetectable		 3abkN-4d3sA:
21.50
3abkP-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.41A 3abmN-4d3sA:
undetectable
3abmP-4d3sA:
undetectable		 3abmN-4d3sA:
21.50
3abmP-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.39A 3ag2A-4d3sA:
undetectable
3ag2C-4d3sA:
undetectable		 3ag2A-4d3sA:
21.50
3ag2C-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.41A 3ag2N-4d3sA:
undetectable
3ag2P-4d3sA:
undetectable		 3ag2N-4d3sA:
21.50
3ag2P-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.40A 3ag3A-4d3sA:
undetectable
3ag3C-4d3sA:
undetectable		 3ag3A-4d3sA:
21.50
3ag3C-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.40A 3ag3N-4d3sA:
2.0
3ag3P-4d3sA:
undetectable		 3ag3N-4d3sA:
21.50
3ag3P-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.39A 3ag4A-4d3sA:
undetectable
3ag4C-4d3sA:
undetectable		 3ag4A-4d3sA:
21.50
3ag4C-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.41A 3ag4N-4d3sA:
undetectable
3ag4P-4d3sA:
undetectable		 3ag4N-4d3sA:
21.50
3ag4P-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		5 / 12 VAL A  81
ILE A  94
VAL A  68
LEU A  70
ALA A  61
 None
 1.16A 4m11D-4d3sA:
undetectable		 4m11D-4d3sA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		5 / 12 VAL A  81
ILE A  94
VAL A  68
LEU A  70
ALA A  61
 None
 1.06A 4o1zB-4d3sA:
undetectable		 4o1zB-4d3sA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.41A 5b1aN-4d3sA:
undetectable
5b1aP-4d3sA:
undetectable		 5b1aN-4d3sA:
21.50
5b1aP-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.40A 5b1bN-4d3sA:
2.0
5b1bP-4d3sA:
undetectable		 5b1bN-4d3sA:
21.50
5b1bP-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		5 / 9 GLY A  20
LEU A  13
ASN A  96
LEU A  97
LEU A 157
 None
 1.08A 5fhzB-4d3sA:
undetectable		 5fhzB-4d3sA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		5 / 10 GLY A  20
LEU A  13
ASN A  96
LEU A  97
LEU A 157
 None
 1.05A 5fhzC-4d3sA:
2.1		 5fhzC-4d3sA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.43A 5iy5A-4d3sA:
undetectable
5iy5C-4d3sA:
undetectable		 5iy5A-4d3sA:
21.50
5iy5C-4d3sA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.40A 5x1fN-4d3sA:
undetectable
5x1fP-4d3sA:
undetectable		 5x1fN-4d3sA:
21.50
5x1fP-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 8 GLU A 148
PHE A 139
PHE A 137
LEU A 177
 None
 1.08A 5y2tB-4d3sA:
undetectable		 5y2tB-4d3sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.42A 5zcqN-4d3sA:
undetectable
5zcqP-4d3sA:
undetectable		 5zcqN-4d3sA:
21.50
5zcqP-4d3sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d3s IMINE REDUCTASE
(Nocardiopsis
halophila) 		4 / 7 HIS A 115
TRP A 111
ASP A 143
TYR A 119
 None
 1.46A 6nmpN-4d3sA:
undetectable
6nmpP-4d3sA:
undetectable		 6nmpN-4d3sA:
21.50
6nmpP-4d3sA:
22.36