SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d3y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		3 / 3 VAL A 146
VAL A  37
TRP A  35
 None
 0.67A 1av2A-4d3yA:
undetectable
1av2B-4d3yA:
undetectable		 1av2A-4d3yA:
2.98
1av2B-4d3yA:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		5 / 11 ILE A  92
ASP A  53
GLY A 235
TYR A 149
ALA A  57
 None
 1.50A 1ju6D-4d3yA:
undetectable		 1ju6D-4d3yA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		5 / 12 VAL A 412
LEU A 413
LEU A 361
LEU A 416
LEU A 360
 None
 0.85A 1mx1C-4d3yA:
undetectable		 1mx1C-4d3yA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		5 / 12 VAL A 412
LEU A 413
LEU A 361
LEU A 416
LEU A 360
 None
 0.87A 1mx1F-4d3yA:
2.6		 1mx1F-4d3yA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		4 / 6 VAL A 358
GLU A 374
LEU A 372
ARG A 370
 None
 1.13A 1s8fB-4d3yA:
undetectable		 1s8fB-4d3yA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		4 / 6 PHE A 391
VAL A 412
LEU A 416
ALA A 387
 None
 0.84A 2e1qA-4d3yA:
undetectable		 2e1qA-4d3yA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		4 / 6 PHE A 391
VAL A 412
LEU A 416
ALA A 387
 None
 0.82A 2e1qC-4d3yA:
undetectable		 2e1qC-4d3yA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		5 / 12 ASN A 241
LEU A 301
GLU A 244
ARG A  94
TYR A 225
 None
 1.34A 2f10A-4d3yA:
undetectable		 2f10A-4d3yA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		4 / 7 TYR A 149
THR A 151
VAL A 240
VAL A 100
 None
SNN  A 152 ( 3.8A)
None
None
 1.00A 2qbnA-4d3yA:
undetectable		 2qbnA-4d3yA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		4 / 7 ILE A 175
TYR A 179
TYR A 184
ASP A 206
 NAG  A 503 ( 4.0A)
None
None
None
 1.11A 2qebA-4d3yA:
undetectable		 2qebA-4d3yA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		4 / 7 ILE A 175
TYR A 179
TYR A 184
ASP A 206
 NAG  A 503 ( 4.0A)
None
None
None
 1.11A 2qebB-4d3yA:
undetectable		 2qebB-4d3yA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		5 / 10 TYR A 149
ALA A 193
ALA A 214
THR A 267
VAL A 263
 None
CSX  A 194 ( 3.1A)
None
None
None
 1.44A 2wuzB-4d3yA:
undetectable		 2wuzB-4d3yA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		4 / 8 PHE A 391
VAL A 412
LEU A 416
ALA A 387
 None
 0.84A 3ax7A-4d3yA:
undetectable		 3ax7A-4d3yA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		4 / 4 LEU A 317
PRO A 316
LEU A 320
ARG A 342
 None
 1.40A 3hcoB-4d3yA:
undetectable		 3hcoB-4d3yA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		5 / 12 ALA A 223
ILE A  79
SER A  82
LEU A 234
THR A 310
 None
 1.08A 3nrrA-4d3yA:
undetectable		 3nrrA-4d3yA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		5 / 12 ALA A 223
ILE A  79
SER A  82
LEU A 234
THR A 310
 None
 1.11A 3nrrB-4d3yA:
undetectable		 3nrrB-4d3yA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		4 / 8 GLU A 192
SER A 312
ALA A 214
ALA A 215
 None
CSX  A 194 ( 3.8A)
None
CSX  A 194 ( 4.6A)
 0.84A 3ns1L-4d3yA:
undetectable		 3ns1L-4d3yA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		4 / 7 PHE A 391
VAL A 412
LEU A 416
ALA A 387
 None
 0.83A 3uniA-4d3yA:
undetectable		 3uniA-4d3yA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		3 / 3 PRO A 316
ASN A  47
HIS A 153
 None
None
SNN  A 152 ( 3.5A)
 1.03A 4ma3H-4d3yA:
undetectable
4ma3L-4d3yA:
undetectable		 4ma3H-4d3yA:
18.63
4ma3L-4d3yA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		3 / 3 LYS A 106
ASN A 117
ASP A  77
 None
 0.89A 4o1eA-4d3yA:
undetectable		 4o1eA-4d3yA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		4 / 4 ASN A 201
VAL A 168
THR A 213
ILE A 191
 None
 1.24A 4retA-4d3yA:
2.4		 4retA-4d3yA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		4 / 4 ASN A 201
VAL A 168
THR A 213
ILE A 191
 None
 1.24A 4retC-4d3yA:
2.5		 4retC-4d3yA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		5 / 10 ALA A 215
THR A 213
ALA A 155
GLY A 154
ASP A 236
 CSX  A 194 ( 4.6A)
None
None
CSX  A 194 ( 3.5A)
None
 0.99A 5lf3H-4d3yA:
undetectable
5lf3I-4d3yA:
undetectable		 5lf3H-4d3yA:
20.44
5lf3I-4d3yA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		5 / 10 ALA A 215
THR A 213
ALA A 155
GLY A 154
ASP A 236
 CSX  A 194 ( 4.6A)
None
None
CSX  A 194 ( 3.5A)
None
 0.97A 5lf3V-4d3yA:
undetectable
5lf3W-4d3yA:
undetectable		 5lf3V-4d3yA:
20.44
5lf3W-4d3yA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		4 / 7 SER A 270
THR A 267
VAL A 263
ILE A 191
 None
 1.15A 5vkqA-4d3yA:
undetectable
5vkqB-4d3yA:
undetectable		 5vkqA-4d3yA:
14.05
5vkqB-4d3yA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		4 / 8 SER A 270
THR A 267
VAL A 263
ILE A 191
 None
 1.12A 5vkqB-4d3yA:
undetectable
5vkqC-4d3yA:
undetectable		 5vkqB-4d3yA:
14.05
5vkqC-4d3yA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		4 / 7 SER A 270
THR A 267
VAL A 263
ILE A 191
 None
 1.15A 5vkqC-4d3yA:
undetectable
5vkqD-4d3yA:
undetectable		 5vkqC-4d3yA:
14.05
5vkqD-4d3yA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		3 / 3 ARG A 408
LYS A 195
ARG A 347
 None
CSX  A 194 ( 3.0A)
None
 1.31A 6az3C-4d3yA:
undetectable
6az3L-4d3yA:
undetectable
6az3M-4d3yA:
undetectable		 6az3C-4d3yA:
12.13
6az3L-4d3yA:
9.07
6az3M-4d3yA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		5 / 12 VAL A  37
ILE A  38
ILE A  60
TYR A 210
ILE A 280
 None
 1.26A 6mkeA-4d3yA:
undetectable
6mkeD-4d3yA:
undetectable		 6mkeA-4d3yA:
13.07
6mkeD-4d3yA:
13.07