SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d47'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		5 / 12 PHE A  53
PRO A 206
PHE A 207
TYR A   4
ALA A 262
 None
 1.47A 1fm4A-4d47A:
undetectable		 1fm4A-4d47A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		5 / 11 ILE A  89
ASN A  74
GLY A 380
ARG A  96
GLY A 379
 None
None
None
GLC  A1416 (-3.2A)
None
 1.47A 1ho5A-4d47A:
undetectable		 1ho5A-4d47A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		4 / 8 LEU A 276
TYR A   4
LEU A 327
TYR A 331
 None
 0.96A 1jlbA-4d47A:
undetectable		 1jlbA-4d47A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		3 / 3 ILE A 144
ASP A  52
PHE A  53
 None
 0.63A 1uwjB-4d47A:
undetectable		 1uwjB-4d47A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		4 / 5 PHE A 207
LEU A 259
PHE A 293
SER A 324
 None
 1.03A 1wrkB-4d47A:
undetectable		 1wrkB-4d47A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		4 / 5 PHE A 207
LEU A 259
PHE A 293
SER A 324
 None
 0.94A 1wrlC-4d47A:
undetectable		 1wrlC-4d47A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		4 / 5 LEU A 218
LEU A 273
CYH A 256
THR A 286
 None
 1.27A 2oaxD-4d47A:
undetectable		 2oaxD-4d47A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		4 / 6 ASP A 367
PHE A 365
ASP A 317
TYR A 352
 GLC  A1416 (-4.4A)
None
None
GLC  A1416 (-4.0A)
 1.37A 2todA-4d47A:
undetectable
2todB-4d47A:
undetectable		 2todA-4d47A:
22.94
2todB-4d47A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_B_DMOB700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		4 / 5 ASP A 317
TYR A 352
ASP A 367
PHE A 365
 None
GLC  A1416 (-4.0A)
GLC  A1416 (-4.4A)
None
 1.38A 2todA-4d47A:
0.0
2todB-4d47A:
0.0		 2todA-4d47A:
22.94
2todB-4d47A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_D_DMOD700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		4 / 5 ASP A 317
TYR A 352
ASP A 367
PHE A 365
 None
GLC  A1416 (-4.0A)
GLC  A1416 (-4.4A)
None
 1.38A 2todC-4d47A:
0.0
2todD-4d47A:
0.0		 2todC-4d47A:
22.94
2todD-4d47A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		5 / 10 VAL A 179
LEU A  69
LEU A 146
GLY A 133
ALA A 132
 None
None
None
None
FRU  A1415 ( 4.7A)
 1.26A 2xf3A-4d47A:
1.9		 2xf3A-4d47A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		3 / 3 THR A 308
ASP A 317
GLU A  21
 None
 0.85A 3qowA-4d47A:
undetectable		 3qowA-4d47A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		4 / 8 LEU A 276
TYR A   4
LEU A 327
TYR A 331
 None
 0.95A 3v81A-4d47A:
undetectable		 3v81A-4d47A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		4 / 7 LEU A 276
TYR A   4
LEU A 327
TYR A 331
 None
 1.09A 4b3qA-4d47A:
undetectable		 4b3qA-4d47A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		4 / 7 ASN A 139
ARG A 141
LEU A 414
GLY A 162
 None
 0.89A 4cp3A-4d47A:
undetectable
4cp3B-4d47A:
undetectable		 4cp3A-4d47A:
14.85
4cp3B-4d47A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		3 / 3 ARG A  73
THR A  90
TRP A  93
 None
 0.68A 4d7hA-4d47A:
undetectable		 4d7hA-4d47A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		4 / 5 ASN A 359
PRO A 358
GLY A 360
ASP A 203
 None
None
None
FRU  A1415 (-2.9A)
 1.11A 4n48B-4d47A:
undetectable		 4n48B-4d47A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		5 / 12 PHE A 207
GLY A  55
ILE A 208
TYR A 216
PRO A 206
 None
 1.26A 4rtpA-4d47A:
undetectable		 4rtpA-4d47A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		3 / 3 ARG A  73
THR A  90
TRP A  93
 None
 0.71A 4ug5A-4d47A:
undetectable		 4ug5A-4d47A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		3 / 3 ARG A  99
THR A  90
TRP A  93
 None
 1.25A 4ug5A-4d47A:
undetectable		 4ug5A-4d47A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		3 / 3 ARG A  73
THR A  90
TRP A  93
 None
 0.63A 4uglA-4d47A:
undetectable		 4uglA-4d47A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_1
(MEDI2452 HEAVY CHAIN
MEDI2452 LIGHT CHAIN)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		5 / 11 SER A 353
ILE A 303
THR A 302
TYR A 352
LEU A  69
 FRU  A1415 ( 4.7A)
None
None
GLC  A1416 (-4.0A)
None
 1.45A 5albH-4d47A:
0.0		 5albH-4d47A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		4 / 6 SER A 181
ARG A 101
GLY A 123
GLU A 122
 None
 1.06A 5btaA-4d47A:
undetectable
5btaB-4d47A:
undetectable
5btaC-4d47A:
undetectable		 5btaA-4d47A:
20.77
5btaB-4d47A:
19.81
5btaC-4d47A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		4 / 6 SER A 181
ARG A 101
GLY A 123
GLU A 122
 None
 1.07A 5btcA-4d47A:
undetectable
5btcB-4d47A:
undetectable
5btcC-4d47A:
undetectable		 5btcA-4d47A:
20.77
5btcB-4d47A:
19.81
5btcC-4d47A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		3 / 3 THR A 308
ASP A 317
GLU A  21
 None
 0.84A 5fa8A-4d47A:
undetectable		 5fa8A-4d47A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		3 / 3 ARG A  73
THR A  90
TRP A  93
 None
 0.70A 5g6cA-4d47A:
undetectable		 5g6cA-4d47A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		5 / 10 ALA A 260
ILE A 272
GLY A 221
PHE A 219
SER A 184
 None
 1.17A 5i6xA-4d47A:
undetectable		 5i6xA-4d47A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		3 / 3 ASP A 203
ASN A 200
PHE A 301
 FRU  A1415 (-2.9A)
None
None
 0.76A 5jglB-4d47A:
undetectable		 5jglB-4d47A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		4 / 7 GLY A 380
ALA A  71
ASP A  46
PHE A 365
 None
None
FRU  A1415 (-2.9A)
None
 0.98A 5mvsA-4d47A:
undetectable		 5mvsA-4d47A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		4 / 8 GLY A 380
ALA A  71
ASP A  46
PHE A 365
 None
None
FRU  A1415 (-2.9A)
None
 0.98A 5mvsB-4d47A:
undetectable		 5mvsB-4d47A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		3 / 3 LYS A 297
VAL A 323
ASP A 325
 None
 0.61A 6fgdA-4d47A:
undetectable		 6fgdA-4d47A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		4 / 6 MET A 237
ALA A 310
LEU A 313
ALA A  16
 None
 1.15A 6fosB-4d47A:
undetectable		 6fosB-4d47A:
10.80