SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4d4g APNAA1
(Planktothrix
agardhii) 		5 / 10 LEU A  71
VAL A  57
TYR A 151
GLY A  58
LEU A  75
 None
 1.42A 1fk9A-4d4gA:
undetectable		 1fk9A-4d4gA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 4d4g APNAA1
(Planktothrix
agardhii) 		5 / 9 LEU A  71
VAL A  57
TYR A 151
GLY A  58
LEU A  75
 None
 1.41A 1ikvA-4d4gA:
undetectable		 1ikvA-4d4gA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 4d4g APNAA1
(Planktothrix
agardhii) 		5 / 10 LEU A  71
VAL A  57
TYR A 151
GLY A  58
LEU A  75
 None
 1.40A 1ikwA-4d4gA:
undetectable		 1ikwA-4d4gA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 4d4g APNAA1
(Planktothrix
agardhii) 		5 / 12 HIS A   7
GLU A 168
ARG A 365
LEU A 149
GLU A  54
 None
 1.26A 1mj2C-4d4gA:
undetectable
1mj2D-4d4gA:
undetectable		 1mj2C-4d4gA:
12.07
1mj2D-4d4gA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 4d4g APNAA1
(Planktothrix
agardhii) 		5 / 12 HIS A   7
GLU A 168
ARG A 365
LEU A 149
GLU A  54
 None
 1.29A 1mjoC-4d4gA:
undetectable
1mjoD-4d4gA:
undetectable		 1mjoC-4d4gA:
12.07
1mjoD-4d4gA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 4d4g APNAA1
(Planktothrix
agardhii) 		5 / 11 GLU A 168
ARG A 365
LEU A 149
GLU A  54
HIS A   7
 None
 1.29A 1mjqI-4d4gA:
undetectable
1mjqJ-4d4gA:
undetectable		 1mjqI-4d4gA:
12.07
1mjqJ-4d4gA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4d4g APNAA1
(Planktothrix
agardhii) 		4 / 7 LEU A 332
ILE A 336
ALA A 307
ILE A 167
 None
None
GOL  A1490 ( 4.3A)
None
 0.88A 1oniB-4d4gA:
undetectable
1oniC-4d4gA:
undetectable		 1oniB-4d4gA:
13.37
1oniC-4d4gA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 4d4g APNAA1
(Planktothrix
agardhii) 		5 / 11 LEU A  35
ALA A  43
ALA A  39
VAL A  23
LEU A 218
 None
 1.11A 1rlbF-4d4gA:
undetectable		 1rlbF-4d4gA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4d4g APNAA1
(Planktothrix
agardhii) 		4 / 5 ILE A 296
LEU A 332
ALA A 179
GLU A 204
 None
None
None
GOL  A1490 ( 4.9A)
 1.03A 1xvaA-4d4gA:
2.6
1xvaB-4d4gA:
2.8		 1xvaA-4d4gA:
20.14
1xvaB-4d4gA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 4d4g APNAA1
(Planktothrix
agardhii) 		4 / 5 LEU A  46
LEU A 125
ILE A 132
ALA A  39
 None
 0.78A 2i2zA-4d4gA:
undetectable		 2i2zA-4d4gA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4d4g APNAA1
(Planktothrix
agardhii) 		4 / 5 PRO A  86
PRO A  83
ILE A 153
TYR A  88
 None
 1.16A 2jkjD-4d4gA:
undetectable		 2jkjD-4d4gA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4d4g APNAA1
(Planktothrix
agardhii) 		4 / 5 PRO A  86
PRO A  83
ILE A 153
TYR A  88
 None
 1.15A 2jkjF-4d4gA:
undetectable		 2jkjF-4d4gA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 4d4g APNAA1
(Planktothrix
agardhii) 		5 / 11 LEU A 244
ILE A 272
GLY A 273
GLY A 274
LEU A 252
 None
None
GOL  A1490 (-3.6A)
ANP  A1489 ( 3.3A)
None
 0.98A 2qmmA-4d4gA:
undetectable
2qmmB-4d4gA:
undetectable		 2qmmA-4d4gA:
18.13
2qmmB-4d4gA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 4d4g APNAA1
(Planktothrix
agardhii) 		5 / 10 HIS A   7
ALA A  39
ASN A  40
ALA A  43
ALA A  73
 None
 1.13A 2r2vC-4d4gA:
undetectable
2r2vF-4d4gA:
undetectable
2r2vG-4d4gA:
undetectable		 2r2vC-4d4gA:
5.54
2r2vF-4d4gA:
5.54
2r2vG-4d4gA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4d4g APNAA1
(Planktothrix
agardhii) 		4 / 7 GLY A 274
GLY A 300
THR A 302
ARG A 420
 ANP  A1489 ( 3.3A)
GOL  A1490 (-3.9A)
ANP  A1489 ( 3.6A)
ANP  A1489 (-3.8A)
 0.31A 2wd9A-4d4gA:
41.6		 2wd9A-4d4gA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4d4g APNAA1
(Planktothrix
agardhii) 		4 / 8 GLY A 274
GLY A 300
THR A 302
ARG A 420
 ANP  A1489 ( 3.3A)
GOL  A1490 (-3.9A)
ANP  A1489 ( 3.6A)
ANP  A1489 (-3.8A)
 0.34A 2wd9B-4d4gA:
43.3		 2wd9B-4d4gA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4d4g APNAA1
(Planktothrix
agardhii) 		5 / 10 THR A 155
GLY A 274
GLY A 300
THR A 302
ARG A 420
 ANP  A1489 (-3.3A)
ANP  A1489 ( 3.3A)
GOL  A1490 (-3.9A)
ANP  A1489 ( 3.6A)
ANP  A1489 (-3.8A)
 0.61A 2wd9C-4d4gA:
42.9		 2wd9C-4d4gA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 4d4g APNAA1
(Planktothrix
agardhii) 		5 / 12 ILE A 358
VAL A 308
ILE A 356
GLU A 355
PRO A 301
 None
None
None
None
ANP  A1489 ( 4.4A)
 1.23A 2yzqA-4d4gA:
undetectable		 2yzqA-4d4gA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 4d4g APNAA1
(Planktothrix
agardhii) 		5 / 12 LEU A  71
VAL A 106
VAL A  82
GLY A  58
ILE A 197
 None
 1.23A 3bf1A-4d4gA:
undetectable
3bf1B-4d4gA:
undetectable		 3bf1A-4d4gA:
18.17
3bf1B-4d4gA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 4d4g APNAA1
(Planktothrix
agardhii) 		5 / 9 LEU A 474
PRO A 484
LEU A 478
LEU A 423
SER A 156
 None
 1.38A 3q1eB-4d4gA:
undetectable
3q1eD-4d4gA:
undetectable		 3q1eB-4d4gA:
12.04
3q1eD-4d4gA:
12.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 4d4g APNAA1
(Planktothrix
agardhii) 		4 / 7 ASP A 200
GLY A 274
THR A 302
LYS A 415
 MG  A1492 (-2.8A)
ANP  A1489 ( 3.3A)
ANP  A1489 ( 3.6A)
ANP  A1489 ( 2.3A)
 0.70A 3vnsA-4d4gA:
50.5		 3vnsA-4d4gA:
33.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 4d4g APNAA1
(Planktothrix
agardhii) 		4 / 6 GLN A 376
ASP A 411
GLN A 413
GLU A 427
 None
None
ANP  A1489 ( 4.9A)
None
 1.48A 4azvA-4d4gA:
3.5		 4azvA-4d4gA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4d4g APNAA1
(Planktothrix
agardhii) 		5 / 12 ASN A  36
PHE A  10
ILE A 132
GLY A  70
ILE A  69
 None
 1.39A 4djfA-4d4gA:
undetectable		 4djfA-4d4gA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 4d4g APNAA1
(Planktothrix
agardhii) 		4 / 7 VAL A  61
SER A 196
MET A  67
LEU A  71
 None
 1.24A 4hxyB-4d4gA:
undetectable		 4hxyB-4d4gA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 4d4g APNAA1
(Planktothrix
agardhii) 		5 / 12 TYR A 367
PRO A 301
ALA A 364
ASP A 381
GLY A 359
 None
ANP  A1489 ( 4.4A)
None
GOL  A1491 (-2.5A)
None
 1.23A 4j7xA-4d4gA:
undetectable		 4j7xA-4d4gA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 4d4g APNAA1
(Planktothrix
agardhii) 		4 / 5 LEU A  75
TYR A  81
ALA A 203
ILE A 206
 None
 1.00A 4y03B-4d4gA:
undetectable		 4y03B-4d4gA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4d4g APNAA1
(Planktothrix
agardhii) 		4 / 7 ARG A 321
TRP A 285
LEU A 313
SER A 314
 None
 1.08A 4zphA-4d4gA:
undetectable
4zphB-4d4gA:
undetectable		 4zphA-4d4gA:
20.70
4zphB-4d4gA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 4d4g APNAA1
(Planktothrix
agardhii) 		4 / 7 ASP A 200
GLY A 274
THR A 302
LYS A 415
 MG  A1492 (-2.8A)
ANP  A1489 ( 3.3A)
ANP  A1489 ( 3.6A)
ANP  A1489 ( 2.3A)
 1.02A 4zxiA-4d4gA:
46.2		 4zxiA-4d4gA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4d4g APNAA1
(Planktothrix
agardhii) 		4 / 6 ARG A 276
GLY A 408
THR A 324
GLU A 325
 None
 1.00A 5btcA-4d4gA:
undetectable
5btcC-4d4gA:
2.4
5btcD-4d4gA:
undetectable		 5btcA-4d4gA:
21.90
5btcC-4d4gA:
21.90
5btcD-4d4gA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4d4g APNAA1
(Planktothrix
agardhii) 		3 / 3 LEU A 453
PHE A 487
ILE A 483
 None
 0.70A 5dzk1-4d4gA:
undetectable
5dzkF-4d4gA:
undetectable
5dzkM-4d4gA:
undetectable		 5dzk1-4d4gA:
2.04
5dzkF-4d4gA:
18.40
5dzkM-4d4gA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4d4g APNAA1
(Planktothrix
agardhii) 		4 / 5 VAL A 152
PRO A  83
GLY A  58
TYR A  81
 None
 1.44A 5x80A-4d4gA:
undetectable
5x80B-4d4gA:
undetectable		 5x80A-4d4gA:
15.36
5x80B-4d4gA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4d4g APNAA1
(Planktothrix
agardhii) 		5 / 10 LEU A  71
VAL A  57
TYR A 151
GLY A  58
LEU A  75
 None
 1.39A 6bsgA-4d4gA:
undetectable		 6bsgA-4d4gA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4d4g APNAA1
(Planktothrix
agardhii) 		5 / 10 LEU A  71
VAL A  57
TYR A 151
GLY A  58
LEU A  75
 None
 1.43A 6bsjA-4d4gA:
undetectable		 6bsjA-4d4gA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4d4g APNAA1
(Planktothrix
agardhii) 		5 / 12 VAL A 231
SER A 234
VAL A 253
LEU A 256
VAL A 270
 None
 1.08A 6drzA-4d4gA:
undetectable		 6drzA-4d4gA:
21.96