SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d4l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		4 / 7 LEU A 137
ILE A 136
ALA A 147
ILE A 150
 None
 0.89A 1oniB-4d4lA:
undetectable
1oniC-4d4lA:
undetectable		 1oniB-4d4lA:
16.14
1oniC-4d4lA:
16.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		12 / 12 PRO A  43
LYS A  47
THR A  48
ASN A  69
GLY A  71
ARG A  75
PHE A  87
ARG A  98
ALA A 125
THR A 126
ARG A 189
TYR A 193
 PO4  A1447 (-4.7A)
PO4  A1447 (-2.8A)
PO4  A1447 (-3.8A)
None
None
None
None
None
None
None
None
None
 0.39A 2axnA-4d4lA:
55.6		 2axnA-4d4lA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		4 / 7 TYR A 333
TYR A 408
TYR A 356
ILE A 323
 F6P  A1448 (-4.8A)
None
None
None
 1.19A 2ph9A-4d4lA:
undetectable
2ph9B-4d4lA:
undetectable		 2ph9A-4d4lA:
18.67
2ph9B-4d4lA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		4 / 7 TYR A  81
PHE A  86
ARG A 189
ARG A  74
 None
 1.34A 2qmqA-4d4lA:
undetectable		 2qmqA-4d4lA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		5 / 12 PHE A 284
LEU A 394
LEU A 250
PHE A 398
THR A 297
 None
 1.19A 2v0mC-4d4lA:
undetectable		 2v0mC-4d4lA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		5 / 12 LEU A 391
LEU A 395
SER A 430
GLN A 388
HIS A 441
 None
None
None
F6P  A1448 ( 4.2A)
None
 1.26A 3m7rA-4d4lA:
undetectable		 3m7rA-4d4lA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		4 / 6 GLU A 360
ILE A 323
GLU A 322
ASN A 321
 None
None
F6P  A1448 (-3.7A)
None
 0.99A 3pgyA-4d4lA:
2.3
3pgyB-4d4lA:
2.1		 3pgyA-4d4lA:
20.00
3pgyB-4d4lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		4 / 4 ILE A 136
VAL A 122
VAL A  38
ARG A 133
 None
 1.21A 4m6tA-4d4lA:
undetectable		 4m6tA-4d4lA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		3 / 3 PRO A 407
MET A 406
TYR A 352
 None
 1.00A 4qa0B-4d4lA:
undetectable		 4qa0B-4d4lA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		3 / 3 PRO A 407
MET A 406
TYR A 352
 None
 1.05A 4qa0A-4d4lA:
undetectable		 4qa0A-4d4lA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		3 / 3 LYS A  53
ASP A 400
ILE A  37
 None
 0.86A 5kc4E-4d4lA:
undetectable		 5kc4E-4d4lA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		4 / 8 LEU A 369
LEU A 391
ILE A 304
THR A 303
 None
 0.99A 5ljbA-4d4lA:
undetectable		 5ljbA-4d4lA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		3 / 3 ARG A  74
GLY A  71
GLU A  72
 None
 0.49A 6fgdA-4d4lA:
undetectable		 6fgdA-4d4lA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		3 / 3 ARG A  75
LYS A 168
TYR A 174
 None
PO4  A1447 (-2.9A)
None
 1.37A 6gnaA-4d4lA:
undetectable		 6gnaA-4d4lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		3 / 3 ARG A  75
LYS A 168
TYR A 174
 None
PO4  A1447 (-2.9A)
None
 1.37A 6gnbA-4d4lA:
undetectable		 6gnbA-4d4lA:
20.92