SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 153
PHE A 141
GLY A 113
GLY A 112
ASP A  97
 None
 1.11A 1mxgA-4d4pA:
undetectable		 1mxgA-4d4pA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		5 / 9 THR A  52
VAL A  49
GLY A  59
VAL A  85
ILE A 101
 None
 1.34A 2a1oB-4d4pA:
undetectable		 2a1oB-4d4pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 240
LEU A 259
THR A 277
TRP A 235
 None
 1.10A 2uz2A-4d4pA:
undetectable		 2uz2A-4d4pA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		5 / 12 GLY A   8
ASN A 299
ASP A  24
GLN A  14
GLY A  18
 None
 1.16A 3eeyB-4d4pA:
undetectable		 3eeyB-4d4pA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 131
VAL A 144
VAL A 142
ASP A 183
 None
 1.14A 3uy4A-4d4pA:
undetectable		 3uy4A-4d4pA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 411
GLY A 414
TYR A 410
GLN A 362
 None
 1.50A 3w9tG-4d4pA:
undetectable		 3w9tG-4d4pA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 402
LYS A 403
ASP A 405
 None
 0.83A 4a7tA-4d4pA:
undetectable		 4a7tA-4d4pA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		4 / 6 SER A 270
GLY A  61
ASP A  62
GLY A  11
 None
 0.99A 4koeA-4d4pA:
undetectable
4koeB-4d4pA:
undetectable
4koeC-4d4pA:
undetectable		 4koeA-4d4pA:
21.89
4koeB-4d4pA:
21.89
4koeC-4d4pA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  15
GLY A 325
GLY A 324
ILE A 274
 None
 0.59A 4yjiA-4d4pA:
undetectable		 4yjiA-4d4pA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		3 / 3 SER A 335
SER A   2
PHE A 323
 None
 0.86A 5mugA-4d4pA:
undetectable		 5mugA-4d4pA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 134
VAL A 143
GLN A 121
 None
 0.50A 5qgjA-4d4pA:
undetectable		 5qgjA-4d4pA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 134
VAL A 143
GLN A 121
 None
 0.48A 5qgmA-4d4pA:
undetectable		 5qgmA-4d4pA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 134
VAL A 143
GLN A 121
 None
 0.55A 5qgnA-4d4pA:
undetectable		 5qgnA-4d4pA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 134
VAL A 143
GLN A 121
 None
 0.54A 5qgyA-4d4pA:
undetectable		 5qgyA-4d4pA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 134
VAL A 143
GLN A 121
 None
 0.51A 5qgzA-4d4pA:
undetectable		 5qgzA-4d4pA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 134
VAL A 143
GLN A 121
 None
 0.53A 5qh0A-4d4pA:
undetectable		 5qh0A-4d4pA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 134
VAL A 143
GLN A 121
 None
 0.52A 5qh2A-4d4pA:
undetectable		 5qh2A-4d4pA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 134
VAL A 143
GLN A 121
 None
 0.52A 5qh3A-4d4pA:
undetectable		 5qh3A-4d4pA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 134
VAL A 143
GLN A 121
 None
 0.54A 5qh5A-4d4pA:
undetectable		 5qh5A-4d4pA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 134
VAL A 143
GLN A 121
 None
 0.47A 5qh6A-4d4pA:
undetectable		 5qh6A-4d4pA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 134
VAL A 143
GLN A 121
 None
 0.53A 5qh7A-4d4pA:
undetectable		 5qh7A-4d4pA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 134
VAL A 143
GLN A 121
 None
 0.48A 5qhaA-4d4pA:
undetectable		 5qhaA-4d4pA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 134
VAL A 143
GLN A 121
 None
 0.52A 5qhhA-4d4pA:
undetectable		 5qhhA-4d4pA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 230
GLU A 271
HIS A 250
 None
 0.79A 5xioA-4d4pA:
undetectable		 5xioA-4d4pA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 230
GLU A 271
HIS A 250
 None
 0.85A 5xiqB-4d4pA:
undetectable		 5xiqB-4d4pA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 230
GLU A 271
HIS A 250
 None
 0.83A 5xiqD-4d4pA:
undetectable		 5xiqD-4d4pA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  59
VAL A  83
PHE A 118
THR A  98
GLY A 113
 None
 1.13A 6brdB-4d4pA:
undetectable		 6brdB-4d4pA:
11.06