SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d4z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 4d4z DEOXYHYPUSINE
HYDROXYLASE
(Homo
sapiens) 		4 / 7 MET A  65
SER A  44
ALA A  39
ILE A  40
 None
 1.02A 1fxhA-4d4zA:
undetectable
1fxhB-4d4zA:
undetectable		 1fxhA-4d4zA:
21.03
1fxhB-4d4zA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4d4z DEOXYHYPUSINE
HYDROXYLASE
(Homo
sapiens) 		5 / 11 ALA A 276
VAL A 222
LEU A 225
ALA A 226
ALA A 230
 None
 1.06A 1jinA-4d4zA:
undetectable		 1jinA-4d4zA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 4d4z DEOXYHYPUSINE
HYDROXYLASE
(Homo
sapiens) 		4 / 8 TYR A 211
HIS A  56
GLU A 208
ASP A 148
 GOL  A 305 ( 3.6A)
FE  A 302 (-3.4A)
GOL  A 305 (-2.6A)
None
 1.27A 1s3zA-4d4zA:
undetectable
1s3zB-4d4zA:
undetectable		 1s3zA-4d4zA:
18.67
1s3zB-4d4zA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 4d4z DEOXYHYPUSINE
HYDROXYLASE
(Homo
sapiens) 		4 / 7 GLU A  93
HIS A  89
LEU A 204
MET A 179
 GOL  A 305 (-2.7A)
FE  A 301 (-3.4A)
None
None
 1.15A 1tuvA-4d4zA:
undetectable		 1tuvA-4d4zA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4d4z DEOXYHYPUSINE
HYDROXYLASE
(Homo
sapiens) 		5 / 12 LEU A 107
ALA A  70
ILE A  71
ILE A  98
ALA A  97
 None
 0.84A 2bxcA-4d4zA:
undetectable		 2bxcA-4d4zA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 4d4z DEOXYHYPUSINE
HYDROXYLASE
(Homo
sapiens) 		4 / 5 LEU A 107
ILE A  71
ILE A  98
ALA A  97
 None
 0.70A 2i2zA-4d4zA:
2.0		 2i2zA-4d4zA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 4d4z DEOXYHYPUSINE
HYDROXYLASE
(Homo
sapiens) 		4 / 4 LEU A 107
ILE A  71
ILE A  98
ALA A  97
 None
 0.81A 2i30A-4d4zA:
undetectable		 2i30A-4d4zA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 4d4z DEOXYHYPUSINE
HYDROXYLASE
(Homo
sapiens) 		4 / 8 HIS A  89
ASN A 235
MET A 237
GLU A 120
 FE  A 301 (-3.4A)
None
OH  A 303 (-4.0A)
None
 0.71A 2x0pA-4d4zA:
undetectable		 2x0pA-4d4zA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4d4z DEOXYHYPUSINE
HYDROXYLASE
(Homo
sapiens) 		3 / 3 THR A  81
ASP A 113
GLU A 117
 None
 0.58A 3qowA-4d4zA:
undetectable		 3qowA-4d4zA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4d4z DEOXYHYPUSINE
HYDROXYLASE
(Homo
sapiens) 		5 / 12 PRO A 101
ALA A  70
ALA A  94
GLY A  63
LEU A  62
 None
 1.10A 4oaeA-4d4zA:
undetectable		 4oaeA-4d4zA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4d4z DEOXYHYPUSINE
HYDROXYLASE
(Homo
sapiens) 		5 / 12 PRO A 252
ALA A 221
ALA A 245
GLY A 214
LEU A 213
 None
 0.98A 4oaeA-4d4zA:
undetectable		 4oaeA-4d4zA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4d4z DEOXYHYPUSINE
HYDROXYLASE
(Homo
sapiens) 		3 / 3 THR A  81
ASP A 113
GLU A 117
 None
 0.58A 5fa8A-4d4zA:
undetectable		 5fa8A-4d4zA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 4d4z DEOXYHYPUSINE
HYDROXYLASE
(Homo
sapiens) 		3 / 3 VAL A 212
GLU A  90
GLU A  93
 None
GOL  A 305 (-2.5A)
GOL  A 305 (-2.7A)
 0.74A 5jsdB-4d4zA:
undetectable
5jsdC-4d4zA:
undetectable		 5jsdB-4d4zA:
17.52
5jsdC-4d4zA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4d4z DEOXYHYPUSINE
HYDROXYLASE
(Homo
sapiens) 		5 / 12 ASP A 167
GLU A 168
LEU A 194
ARG A 177
LEU A 172
 None
 1.33A 5nd4B-4d4zA:
undetectable		 5nd4B-4d4zA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 4d4z DEOXYHYPUSINE
HYDROXYLASE
(Homo
sapiens) 		3 / 3 GLU A 266
HIS A 240
VAL A 269
 None
FE  A 302 (-3.5A)
None
 0.87A 5trqB-4d4zA:
undetectable		 5trqB-4d4zA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4d4z DEOXYHYPUSINE
HYDROXYLASE
(Homo
sapiens) 		4 / 7 LEU A  28
VAL A 268
GLU A 244
SER A 272
 None
 1.23A 5umwA-4d4zA:
undetectable
5umwF-4d4zA:
undetectable		 5umwA-4d4zA:
13.99
5umwF-4d4zA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 4d4z DEOXYHYPUSINE
HYDROXYLASE
(Homo
sapiens) 		5 / 12 GLY A  96
GLY A  63
VAL A 147
GLN A  83
ALA A  91
 None
None
None
B3P  A 306 (-3.8A)
None
 1.24A 5x7fA-4d4zA:
undetectable		 5x7fA-4d4zA:
26.10