SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 4d59 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		6 / 10 GLN A 110
TRP A 117
PHE A 119
SER A 120
HIS A 262
ALA A 263
 None
 0.64A 1stfE-4d59A:
15.1
1stfI-4d59A:
0.2		 1stfE-4d59A:
20.40
1stfI-4d59A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)		 4d59 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		4 / 6 SER A 294
PHE A 299
PHE A 244
HIS A 239
 None
 1.27A 3lskD-4d59A:
undetectable		 3lskD-4d59A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4d59 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		4 / 5 VAL A 489
PHE A 358
ILE A 428
PHE A 360
 None
 1.07A 3owxB-4d59A:
undetectable		 3owxB-4d59A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4d59 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		3 / 3 TYR A 454
GLU A 340
TYR A 341
 None
 0.81A 3ug8A-4d59A:
undetectable		 3ug8A-4d59A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 4d59 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		4 / 5 LEU A 315
GLY A 236
PHE A 306
ASN A 261
 None
 1.15A 3uq6B-4d59A:
undetectable		 3uq6B-4d59A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4d59 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		5 / 11 SER A 443
VAL A 430
LEU A 445
THR A 444
VAL A 383
 None
 1.15A 4e0fA-4d59A:
undetectable		 4e0fA-4d59A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4d59 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		4 / 8 GLY A 170
GLY A 343
GLU A 340
GLU A 373
 None
 0.75A 4fgzB-4d59A:
undetectable		 4fgzB-4d59A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 4d59 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		3 / 3 SER A 118
MET A 122
ASP A 320
 None
 0.95A 4mm4B-4d59A:
undetectable		 4mm4B-4d59A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 4d59 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		5 / 12 ILE A 493
THR A 494
LEU A 367
LEU A 421
PHE A 358
 None
 1.18A 4pbhA-4d59A:
undetectable		 4pbhA-4d59A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 4d59 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		4 / 5 ILE A 308
HIS A 239
HIS A 262
TYR A 237
 None
 1.39A 5ocsA-4d59A:
undetectable		 5ocsA-4d59A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 4d59 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		4 / 5 ILE A 308
HIS A 239
HIS A 262
TYR A 237
 None
 1.39A 5ocsC-4d59A:
undetectable		 5ocsC-4d59A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WQP_A_NCAA302_0
(PROBABLE
DEHYDROGENASE)		 4d59 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		4 / 8 GLN A 338
MET A 371
TYR A 411
TRP A 175
 None
 1.25A 5wqpA-4d59A:
undetectable		 5wqpA-4d59A:
20.96