SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		5 / 11 THR A 103
SER A 106
ALA A 107
ALA A  56
THR A  58
 None
 1.19A 2f16H-4d5cA:
undetectable
2f16I-4d5cA:
undetectable		 2f16H-4d5cA:
22.67
2f16I-4d5cA:
24.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		7 / 12 HIS A  64
PHE A  86
HIS A 100
ARG A 104
PRO A 105
THR A 112
GLN A 116
 None
 0.82A 2fj1A-4d5cA:
26.3		 2fj1A-4d5cA:
59.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		8 / 12 HIS A  64
ASN A  82
PHE A  86
HIS A 100
ARG A 104
PRO A 105
THR A 112
GLN A 116
 None
 0.87A 2o7oA-4d5cA:
26.1		 2o7oA-4d5cA:
59.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TCT_A_CTCA222_0
(TETRACYCLINE
REPRESSOR)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		8 / 12 HIS A  64
PHE A  86
HIS A 100
ARG A 104
PRO A 105
GLN A 109
THR A 112
GLN A 116
 None
 0.81A 2tctA-4d5cA:
26.7		 2tctA-4d5cA:
60.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		7 / 11 HIS A  64
ASN A  82
PHE A  86
HIS A 100
ARG A 104
PRO A 105
GLN A 116
 None
 0.75A 2trtA-4d5cA:
26.6		 2trtA-4d5cA:
60.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		7 / 11 HIS A  64
ASN A  82
PHE A  86
HIS A 100
ARG A 104
PRO A 105
GLN A 116
 None
 0.74A 2vkeA-4d5cA:
26.4		 2vkeA-4d5cA:
59.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		7 / 12 HIS A  64
ASN A  82
PHE A  86
ARG A 104
PRO A 105
THR A 112
GLN A 116
 None
 0.79A 2xpvA-4d5cA:
26.9		 2xpvA-4d5cA:
59.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		7 / 12 HIS A  64
ASN A  82
PHE A  86
HIS A 100
ARG A 104
PRO A 105
GLN A 116
 None
 0.75A 2xpvA-4d5cA:
26.9		 2xpvA-4d5cA:
59.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		8 / 12 LEU A  60
HIS A  64
ASN A  82
PHE A  86
HIS A 100
ARG A 104
PRO A 105
GLN A 116
 None
 0.88A 2xpwA-4d5cA:
25.7		 2xpwA-4d5cA:
59.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		7 / 12 HIS A  64
ASN A  82
PHE A  86
HIS A 100
PRO A 105
GLN A 116
LEU A 117
 None
 0.78A 2xrlA-4d5cA:
25.8		 2xrlA-4d5cA:
59.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		7 / 12 HIS A  64
ASN A  82
PHE A  86
PRO A 105
THR A 112
GLN A 116
LEU A 117
 None
 0.73A 2xrlA-4d5cA:
25.8		 2xrlA-4d5cA:
59.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		4 / 4 LEU A  14
ARG A  49
LEU A  51
ALA A  56
 None
 1.04A 3b9mA-4d5cA:
2.9		 3b9mA-4d5cA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		4 / 7 HIS A  44
LEU A  41
LEU A   4
LEU A  34
 None
 0.92A 3bgdB-4d5cA:
undetectable		 3bgdB-4d5cA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		4 / 5 LEU A  52
LEU A  25
GLY A  24
GLY A  21
 None
 0.85A 3si7C-4d5cA:
undetectable
3si7D-4d5cA:
undetectable		 3si7C-4d5cA:
21.83
3si7D-4d5cA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		4 / 6 SER A 144
LEU A  90
HIS A 100
THR A 141
 None
 1.40A 3thrB-4d5cA:
undetectable		 3thrB-4d5cA:
20.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		8 / 12 HIS A  64
ASN A  82
PHE A  86
ARG A 104
PRO A 105
GLN A 109
THR A 112
GLN A 116
 None
 0.94A 4abzA-4d5cA:
26.2		 4abzA-4d5cA:
59.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		8 / 12 HIS A  64
ASN A  82
PHE A  86
HIS A 100
ARG A 104
PRO A 105
GLN A 109
GLN A 116
 None
 0.90A 4abzA-4d5cA:
26.2		 4abzA-4d5cA:
59.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		5 / 12 PHE A  86
HIS A 100
PRO A 105
GLN A 109
LEU A 117
 None
 1.11A 4abzA-4d5cA:
26.2		 4abzA-4d5cA:
59.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		7 / 12 HIS A  64
ASN A  82
PHE A  86
HIS A 100
ARG A 104
THR A 112
GLN A 116
 None
 0.73A 4ac0A-4d5cA:
26.7		 4ac0A-4d5cA:
65.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		8 / 12 HIS A  64
ASN A  82
PHE A  86
HIS A 100
PRO A 105
GLN A 109
THR A 112
GLN A 116
 None
 0.92A 4ac0A-4d5cA:
26.7		 4ac0A-4d5cA:
65.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		5 / 12 PHE A  86
HIS A 100
PRO A 105
GLN A 109
LEU A 117
 None
 1.06A 4ac0A-4d5cA:
26.7		 4ac0A-4d5cA:
65.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		8 / 12 LEU A  60
HIS A  64
ASN A  82
PHE A  86
ARG A 104
PRO A 105
GLN A 109
GLN A 116
 None
 0.84A 4b3aA-4d5cA:
26.6		 4b3aA-4d5cA:
59.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		5 / 10 LEU A  55
LEU A  51
LEU A   4
ASN A  12
VAL A  36
 None
 1.21A 4po0A-4d5cA:
3.7		 4po0A-4d5cA:
16.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		8 / 12 HIS A  64
ASN A  82
PHE A  86
HIS A 100
ARG A 104
PRO A 105
THR A 112
GLN A 116
 None
 0.78A 4v2gB-4d5cA:
26.3		 4v2gB-4d5cA:
59.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR
(Proteus
mirabilis) 		4 / 6 THR A 126
THR A 128
VAL A 131
TYR A 132
 None
 0.93A 5ecoA-4d5cA:
undetectable		 5ecoA-4d5cA:
18.45