SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d5r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4d5r A49
(Vaccinia
virus) 		5 / 12 ILE A 150
LEU A  43
PHE A  61
ILE A 113
LEU A  65
 None
 1.15A 1jolA-4d5rA:
undetectable		 1jolA-4d5rA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4d5r A49
(Vaccinia
virus) 		5 / 11 ILE A 113
LEU A 106
ILE A 150
VAL A  68
PHE A  61
 None
 1.15A 3b2rB-4d5rA:
undetectable		 3b2rB-4d5rA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4d5r A49
(Vaccinia
virus) 		5 / 9 ILE A 140
LEU A  65
PHE A 101
ILE A  51
ILE A 137
 None
 1.20A 3tq8A-4d5rA:
undetectable		 3tq8A-4d5rA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 4d5r A49
(Vaccinia
virus) 		3 / 3 LYS A  34
LEU A  30
ALA A  33
 None
 0.82A 4iizA-4d5rA:
undetectable		 4iizA-4d5rA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 4d5r A49
(Vaccinia
virus) 		5 / 12 LEU A  65
LEU A 153
ASN A 108
ILE A 146
ILE A 142
 None
 1.00A 4o2bB-4d5rA:
undetectable		 4o2bB-4d5rA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 4d5r A49
(Vaccinia
virus) 		5 / 12 LEU A  65
LEU A 153
ASN A 108
ILE A 146
ILE A 142
 None
 0.97A 4o2bD-4d5rA:
undetectable		 4o2bD-4d5rA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4d5r A49
(Vaccinia
virus) 		5 / 12 GLY A 134
SER A 135
ILE A  47
ASN A  44
ASN A  49
 None
 1.22A 4obwA-4d5rA:
undetectable		 4obwA-4d5rA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4d5r A49
(Vaccinia
virus) 		5 / 12 GLY A 134
SER A 135
ILE A  47
ASN A  44
ASN A  49
 None
 1.19A 4obwC-4d5rA:
undetectable		 4obwC-4d5rA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 4d5r A49
(Vaccinia
virus) 		4 / 6 LEU A 151
LEU A 106
ILE A  27
PHE A  64
 None
 1.21A 4y4dA-4d5rA:
undetectable		 4y4dA-4d5rA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4d5r A49
(Vaccinia
virus) 		5 / 12 LEU A  65
LEU A 153
ASN A 108
ILE A 146
ILE A 142
 None
 0.95A 5mioB-4d5rA:
undetectable		 5mioB-4d5rA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 4d5r A49
(Vaccinia
virus) 		4 / 8 ILE A 137
ILE A 109
ALA A 112
ILE A 113
 None
 0.54A 5mvmA-4d5rA:
undetectable
5mvmB-4d5rA:
undetectable		 5mvmA-4d5rA:
23.13
5mvmB-4d5rA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 4d5r A49
(Vaccinia
virus) 		4 / 7 LEU A  65
PHE A  61
ILE A  42
ASN A  49
 None
 0.93A 5n5dA-4d5rA:
undetectable		 5n5dA-4d5rA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 4d5r A49
(Vaccinia
virus) 		6 / 12 PHE A  64
ILE A 150
ILE A 109
ASN A 108
LEU A 153
VAL A  68
 None
 1.30A 5uvmB-4d5rA:
undetectable		 5uvmB-4d5rA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4d5r A49
(Vaccinia
virus) 		5 / 10 TYR A 102
ILE A 146
ILE A  32
LEU A 151
ASN A 108
 None
 1.29A 5vkqA-4d5rA:
undetectable
5vkqD-4d5rA:
undetectable		 5vkqA-4d5rA:
7.16
5vkqD-4d5rA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4d5r A49
(Vaccinia
virus) 		5 / 10 ASN A 108
TYR A 102
ILE A 146
ILE A  32
LEU A 151
 None
 1.27A 5vkqA-4d5rA:
undetectable
5vkqB-4d5rA:
undetectable		 5vkqA-4d5rA:
7.16
5vkqB-4d5rA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4d5r A49
(Vaccinia
virus) 		5 / 10 ASN A 108
TYR A 102
ILE A 146
ILE A  32
LEU A 151
 None
 1.29A 5vkqC-4d5rA:
undetectable
5vkqD-4d5rA:
undetectable		 5vkqC-4d5rA:
7.16
5vkqD-4d5rA:
7.16