SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d61'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens) 		4 / 8 PHE i 276
ASP i 478
HIS i 282
ILE i 285
 None
 0.95A 1ei6C-4d61i:
undetectable		 1ei6C-4d61i:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens) 		5 / 11 ILE i 545
LEU i 543
ARG i 605
GLY i 618
LYS i 619
 None
 1.16A 2bxmA-4d61i:
undetectable		 2bxmA-4d61i:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens) 		5 / 11 LEU i 586
GLY i 618
VAL i 561
ILE i 528
ILE i 554
 None
 0.94A 3ebzB-4d61i:
undetectable		 3ebzB-4d61i:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens) 		4 / 6 ILE i 526
MET i 334
ILE i 529
HIS i 531
 None
 1.18A 3eteA-4d61i:
undetectable
3eteE-4d61i:
undetectable		 3eteA-4d61i:
23.86
3eteE-4d61i:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens) 		4 / 7 MET i 334
ILE i 529
HIS i 531
ILE i 526
 None
 1.16A 3eteD-4d61i:
undetectable
3eteF-4d61i:
undetectable		 3eteD-4d61i:
23.86
3eteF-4d61i:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens) 		4 / 5 ASN i 397
THR i 355
SER i 359
ARG i 362
 None
 0.96A 3hlwB-4d61i:
undetectable		 3hlwB-4d61i:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens) 		6 / 12 GLY i 395
GLY i 392
LEU i 226
PHE i 413
ALA i 396
ASN i 397
 None
 1.46A 3kkzA-4d61i:
undetectable		 3kkzA-4d61i:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens) 		4 / 5 VAL i 552
ILE i 558
TYR i 539
ILE i 583
 None
 0.92A 4c8bA-4d61i:
undetectable		 4c8bA-4d61i:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens) 		3 / 3 TYR i 251
THR i 258
GLU i 244
 None
 0.82A 4df3B-4d61i:
undetectable		 4df3B-4d61i:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens) 		5 / 10 LEU i 586
ILE i 545
LEU i 594
LEU i 608
PHE i 522
 None
 1.07A 4odoB-4d61i:
3.1		 4odoB-4d61i:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens) 		5 / 10 LEU i 586
ILE i 545
LEU i 594
LEU i 608
PHE i 522
 None
 1.06A 4odoC-4d61i:
2.7		 4odoC-4d61i:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens) 		4 / 5 SER i 452
GLY i 453
ARG i 432
PHE i 600
 None
 1.29A 4r82A-4d61i:
2.6
4r82B-4d61i:
undetectable		 4r82A-4d61i:
18.66
4r82B-4d61i:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens) 		4 / 4 ASN i 490
VAL i 271
THR i 284
ILE i 285
 None
 1.11A 4retA-4d61i:
undetectable		 4retA-4d61i:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens) 		4 / 4 ASN i 490
VAL i 271
THR i 284
ILE i 285
 None
 1.11A 4retC-4d61i:
undetectable		 4retC-4d61i:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens) 		5 / 12 PHE i 522
HIS i 544
ARG i 609
LEU i 608
ILE i 615
 None
 1.10A 4x1fA-4d61i:
undetectable		 4x1fA-4d61i:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens) 		4 / 7 ILE i 545
LEU i 543
GLY i 618
LYS i 619
 None
 0.90A 4z69A-4d61i:
undetectable		 4z69A-4d61i:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens) 		4 / 5 VAL i 485
THR i 482
LEU i 433
LEU i 495
 None
 1.02A 6bqgA-4d61i:
undetectable		 6bqgA-4d61i:
11.91