SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d65'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4d65 PORIN 2
(Providencia
stuartii) 		5 / 12 VAL A  97
GLY A  96
MET A 123
LEU A 130
ASN A  94
 None
 1.26A 1a27A-4d65A:
undetectable		 1a27A-4d65A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 4d65 PORIN 2
(Providencia
stuartii) 		4 / 6 ARG A 134
ASP A  90
THR A 132
ASP A 100
 None
 0.76A 2j2pE-4d65A:
undetectable
2j2pF-4d65A:
undetectable		 2j2pE-4d65A:
19.60
2j2pF-4d65A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4d65 PORIN 2
(Providencia
stuartii) 		5 / 12 ARG A 197
PHE A 242
ILE A 250
GLY A 207
ALA A 208
 None
 1.22A 3n8xA-4d65A:
undetectable		 3n8xA-4d65A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4d65 PORIN 2
(Providencia
stuartii) 		5 / 12 GLY A 219
ALA A 231
THR A 105
ILE A 188
VAL A 218
 LDA  A1372 (-3.5A)
LDA  A1373 ( 3.9A)
None
LDA  A1346 ( 4.1A)
LDA  A1372 (-4.1A)
 1.14A 3nvkI-4d65A:
undetectable		 3nvkI-4d65A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4d65 PORIN 2
(Providencia
stuartii) 		5 / 12 GLY A 191
GLY A 175
SER A 193
LEU A 149
ALA A 179
 LDA  A1370 ( 4.6A)
LDA  A1383 ( 4.2A)
None
LDA  A1365 ( 4.3A)
None
 1.03A 3ou6A-4d65A:
undetectable		 3ou6A-4d65A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4d65 PORIN 2
(Providencia
stuartii) 		5 / 12 GLY A 191
GLY A 175
SER A 193
LEU A 149
ALA A 179
 LDA  A1370 ( 4.6A)
LDA  A1383 ( 4.2A)
None
LDA  A1365 ( 4.3A)
None
 1.04A 3ou6B-4d65A:
undetectable		 3ou6B-4d65A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4d65 PORIN 2
(Providencia
stuartii) 		5 / 12 GLY A 191
GLY A 175
SER A 193
LEU A 149
ALA A 179
 LDA  A1370 ( 4.6A)
LDA  A1383 ( 4.2A)
None
LDA  A1365 ( 4.3A)
None
 1.06A 3ou7B-4d65A:
undetectable		 3ou7B-4d65A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 4d65 PORIN 2
(Providencia
stuartii) 		5 / 12 TYR A 233
GLY A 234
ASN A 102
ALA A 251
LEU A 291
 LDA  A1372 (-4.3A)
None
None
None
None
 1.02A 3vywA-4d65A:
undetectable		 3vywA-4d65A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 4d65 PORIN 2
(Providencia
stuartii) 		5 / 12 TYR A 233
GLY A 234
ASN A 102
ALA A 251
LEU A 291
 LDA  A1372 (-4.3A)
None
None
None
None
 1.05A 3vywB-4d65A:
undetectable		 3vywB-4d65A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 4d65 PORIN 2
(Providencia
stuartii) 		5 / 12 TYR A 233
GLY A 234
ASN A 102
ALA A 251
LEU A 291
 LDA  A1372 (-4.3A)
None
None
None
None
 0.98A 3vywD-4d65A:
undetectable		 3vywD-4d65A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4d65 PORIN 2
(Providencia
stuartii) 		4 / 7 TYR A  95
LEU A 262
THR A 270
MET A 232
 None
 1.09A 4mbsA-4d65A:
undetectable		 4mbsA-4d65A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 4d65 PORIN 2
(Providencia
stuartii) 		4 / 5 THR A 132
PHE A  54
ASN A  94
TYR A  78
 None
 1.50A 4mf6A-4d65A:
undetectable		 4mf6A-4d65A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 4d65 PORIN 2
(Providencia
stuartii) 		4 / 7 THR A 239
GLN A 152
ALA A 215
ILE A  98
 None
 0.93A 4txnA-4d65A:
undetectable		 4txnA-4d65A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 4d65 PORIN 2
(Providencia
stuartii) 		4 / 7 THR A 239
GLN A 152
ALA A 215
ILE A  98
 None
 0.93A 4txnB-4d65A:
undetectable		 4txnB-4d65A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 4d65 PORIN 2
(Providencia
stuartii) 		4 / 7 THR A 239
GLN A 152
ALA A 215
ILE A  98
 None
 0.93A 4txnC-4d65A:
undetectable		 4txnC-4d65A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 4d65 PORIN 2
(Providencia
stuartii) 		4 / 7 THR A 239
GLN A 152
ALA A 215
ILE A  98
 None
 0.93A 4txnD-4d65A:
undetectable		 4txnD-4d65A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4d65 PORIN 2
(Providencia
stuartii) 		3 / 3 ASP A  34
ARG A 126
ARG A  38
 None
 0.89A 4x5iA-4d65A:
undetectable		 4x5iA-4d65A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4d65 PORIN 2
(Providencia
stuartii) 		5 / 12 GLY A 210
GLY A 243
LEU A 167
PHE A 122
THR A 209
 None
 1.30A 4ze1A-4d65A:
undetectable		 4ze1A-4d65A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4d65 PORIN 2
(Providencia
stuartii) 		3 / 3 ASP A 114
ARG A  38
ARG A  20
 None
 0.95A 5eajB-4d65A:
undetectable		 5eajB-4d65A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4d65 PORIN 2
(Providencia
stuartii) 		5 / 7 GLY A  53
GLY A  55
PHE A  41
GLY A  43
LEU A  11
 None
 0.86A 5izjB-4d65A:
undetectable		 5izjB-4d65A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4d65 PORIN 2
(Providencia
stuartii) 		4 / 7 ASP A 117
ARG A 126
TYR A  95
GLU A  60
 None
 1.33A 6mn5E-4d65A:
undetectable		 6mn5E-4d65A:
12.89