SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d6y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F8D_A_BEZA1002_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM)	4d6y	BACTERIAL REGULATORY, FIS FAMILY PROTEIN (Brucella abortus)	6 / 10	LEU A 61 GLY A 63 LEU A 67 LEU A 66 ILE A 70 ARG A 97	None	1.41A	2f8dA-4d6yA: undetectable	2f8dA-4d6yA: 24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F8D_B_BEZB1003_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM)	4d6y	BACTERIAL REGULATORY, FIS FAMILY PROTEIN (Brucella abortus)	6 / 10	LEU A 61 GLY A 63 LEU A 67 LEU A 66 ILE A 70 ARG A 97	None	1.41A	2f8dB-4d6yA: undetectable	2f8dB-4d6yA: 24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GP0_A_NILA1_2 (MITOGEN-ACTIVATED PROTEIN KINASE 11)	4d6y	BACTERIAL REGULATORY, FIS FAMILY PROTEIN (Brucella abortus)	4 / 7	LYS A 71 VAL A 7 LEU A 67 ILE A 5	None	1.00A	3gp0A-4d6yA: undetectable	3gp0A-4d6yA: 20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UJ7_A_SAMA301_1 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE)	4d6y	BACTERIAL REGULATORY, FIS FAMILY PROTEIN (Brucella abortus)	3 / 3	SER A 59 ASP A 9 ASP A 16	None MG A1126 ( 4.1A) None	0.91A	3uj7A-4d6yA: 3.0	3uj7A-4d6yA: 23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MWZ_A_SAMA301_1 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE)	4d6y	BACTERIAL REGULATORY, FIS FAMILY PROTEIN (Brucella abortus)	3 / 3	SER A 59 ASP A 9 ASP A 16	None MG A1126 ( 4.1A) None	0.91A	4mwzA-4d6yA: 3.2	4mwzA-4d6yA: 20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XJE_A_TOYA202_1 (AADB)	4d6y	BACTERIAL REGULATORY, FIS FAMILY PROTEIN (Brucella abortus)	4 / 8	ASP A 10 ASP A 53 ASP A 9 ILE A 103	MG A1126 (-2.6A) BEF A1125 ( 2.2A) MG A1126 ( 4.1A) None	1.00A	4xjeA-4d6yA: undetectable	4xjeA-4d6yA: 24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZN7_A_DESA601_1 (ESTROGEN RECEPTOR)	4d6y	BACTERIAL REGULATORY, FIS FAMILY PROTEIN (Brucella abortus)	5 / 12	LEU A 39 ALA A 38 LEU A 52 LEU A 61 LEU A 6	None	1.23A	4zn7A-4d6yA: undetectable	4zn7A-4d6yA: 21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CFS_A_TOYA203_1 (AAD(2''),GENTAMICIN 2''-NUCLEOTIDYLTRANS FERASE,GENTAMICIN RESISTANCE PROTEIN)	4d6y	BACTERIAL REGULATORY, FIS FAMILY PROTEIN (Brucella abortus)	4 / 8	ASP A 10 ASP A 53 ASP A 9 ILE A 103	MG A1126 (-2.6A) BEF A1125 ( 2.2A) MG A1126 ( 4.1A) None	1.01A	5cfsA-4d6yA: undetectable	5cfsA-4d6yA: 24.61

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2F8D_A_BEZA1002_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM","4d6y","BACTERIAL REGULATORY, FIS FAMILY PROTEIN","Brucella abortus",6,"LEU A  61;GLY A  63;LEU A  67;LEU A  66;ILE A  70;ARG A  97","None","1.41A","2f8dA-4d6yA:undetectable","2f8dA-4d6yA:24.89"],["2F8D_B_BEZB1003_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM","4d6y","BACTERIAL REGULATORY, FIS FAMILY PROTEIN","Brucella abortus",6,"LEU A  61;GLY A  63;LEU A  67;LEU A  66;ILE A  70;ARG A  97","None","1.41A","2f8dB-4d6yA:undetectable","2f8dB-4d6yA:24.89"],["3GP0_A_NILA1_2","MITOGEN-ACTIVATED PROTEIN KINASE 11","4d6y","BACTERIAL REGULATORY, FIS FAMILY PROTEIN","Brucella abortus",4,"LYS A  71;VAL A   7;LEU A  67;ILE A   5","None","1.00A","3gp0A-4d6yA:undetectable","3gp0A-4d6yA:20.45"],["3UJ7_A_SAMA301_1","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE","4d6y","BACTERIAL REGULATORY, FIS FAMILY PROTEIN","Brucella abortus",3,"SER A  59;ASP A   9;ASP A  16","None; MG A1126 ( 4.1A);None","0.91A","3uj7A-4d6yA:3.0","3uj7A-4d6yA:23.35"],["4MWZ_A_SAMA301_1","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE","4d6y","BACTERIAL REGULATORY, FIS FAMILY PROTEIN","Brucella abortus",3,"SER A  59;ASP A   9;ASP A  16","None; MG A1126 ( 4.1A);None","0.91A","4mwzA-4d6yA:3.2","4mwzA-4d6yA:20.21"],["4XJE_A_TOYA202_1","AADB","4d6y","BACTERIAL REGULATORY, FIS FAMILY PROTEIN","Brucella abortus",4,"ASP A  10;ASP A  53;ASP A   9;ILE A 103"," MG A1126 (-2.6A);BEF A1125 ( 2.2A); MG A1126 ( 4.1A);None","1.00A","4xjeA-4d6yA:undetectable","4xjeA-4d6yA:24.61"],["4ZN7_A_DESA601_1","ESTROGEN RECEPTOR","4d6y","BACTERIAL REGULATORY, FIS FAMILY PROTEIN","Brucella abortus",5,"LEU A  39;ALA A  38;LEU A  52;LEU A  61;LEU A   6","None","1.23A","4zn7A-4d6yA:undetectable","4zn7A-4d6yA:21.62"],["5CFS_A_TOYA203_1","AAD(2''),GENTAMICIN 2''-NUCLEOTIDYLTRANSFERASE,GENTAMICIN RESISTANCE PROTEIN","4d6y","BACTERIAL REGULATORY, FIS FAMILY PROTEIN","Brucella abortus",4,"ASP A  10;ASP A  53;ASP A   9;ILE A 103"," MG A1126 (-2.6A);BEF A1125 ( 2.2A); MG A1126 ( 4.1A);None","1.01A","5cfsA-4d6yA:undetectable","5cfsA-4d6yA:24.61"]]