SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d72'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 591
ALA A 595
GLY A 593
TYR A 560
 None
None
None
NAG  A2009 (-4.6A)
 1.11A 1c8lA-4d72A:
undetectable		 1c8lA-4d72A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 591
ALA A 595
GLY A 593
TYR A 560
 None
None
None
NAG  A2009 (-4.6A)
 1.05A 1gfzA-4d72A:
undetectable		 1gfzA-4d72A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 5 THR A 658
PHE A 709
GLU A 695
GLY A 693
 None
 1.35A 1icrA-4d72A:
undetectable
1icrB-4d72A:
undetectable		 1icrA-4d72A:
16.04
1icrB-4d72A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 5 GLU A 695
GLY A 693
THR A 658
PHE A 709
 None
 1.33A 1icrA-4d72A:
undetectable
1icrB-4d72A:
undetectable		 1icrA-4d72A:
16.04
1icrB-4d72A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 591
ALA A 595
GLY A 593
TYR A 560
 None
None
None
NAG  A2009 (-4.6A)
 1.02A 1l5qA-4d72A:
undetectable		 1l5qA-4d72A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 591
ALA A 595
GLY A 593
TYR A 560
 None
None
None
NAG  A2009 (-4.6A)
 1.03A 1l5qB-4d72A:
undetectable		 1l5qB-4d72A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 591
ALA A 595
GLY A 593
TYR A 560
 None
None
None
NAG  A2009 (-4.6A)
 1.03A 1l7xA-4d72A:
undetectable		 1l7xA-4d72A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 591
ALA A 595
GLY A 593
TYR A 560
 None
None
None
NAG  A2009 (-4.6A)
 0.99A 1l7xB-4d72A:
undetectable		 1l7xB-4d72A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		3 / 3 ASP A 657
LEU A 655
HIS A 530
 None
None
NAG  A2009 ( 4.4A)
 0.78A 1qknA-4d72A:
undetectable		 1qknA-4d72A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 5 MET A 527
ALA A 524
ILE A 562
ASP A 566
 None
FUC  A2007 ( 4.0A)
None
None
 1.06A 1upfA-4d72A:
undetectable		 1upfA-4d72A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 5 MET A 527
ALA A 524
ILE A 562
ASP A 566
 None
FUC  A2007 ( 4.0A)
None
None
 1.09A 1upfC-4d72A:
undetectable		 1upfC-4d72A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 792
ILE A 816
ARG A 827
SER A 638
PHE A 769
 None
 1.11A 1ve3B-4d72A:
undetectable		 1ve3B-4d72A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		5 / 12 THR A 520
LEU A 519
ILE A 518
VAL A 475
ASN A 550
 None
 1.16A 1wsvA-4d72A:
undetectable		 1wsvA-4d72A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		5 / 12 THR A 520
LEU A 519
ILE A 518
VAL A 475
ASN A 550
 None
 1.20A 1wsvB-4d72A:
undetectable		 1wsvB-4d72A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		5 / 11 LEU A1001
LEU A 895
ILE A 991
THR A 950
ASN A 901
 None
 1.18A 2ft9A-4d72A:
3.2		 2ft9A-4d72A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		5 / 11 LEU A1001
LEU A 895
ILE A 991
THR A 950
MET A 876
 None
 1.26A 2ft9A-4d72A:
3.2		 2ft9A-4d72A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 5 SER A 761
ASP A 759
PRO A 794
SER A 594
 None
 1.47A 2hdnA-4d72A:
undetectable
2hdnB-4d72A:
1.1
2hdnD-4d72A:
2.1		 2hdnA-4d72A:
5.84
2hdnB-4d72A:
21.67
2hdnD-4d72A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 5 SER A 594
SER A 761
ASP A 759
PRO A 794
 None
 1.42A 2hdnB-4d72A:
1.1
2hdnC-4d72A:
undetectable
2hdnD-4d72A:
2.1		 2hdnB-4d72A:
21.67
2hdnC-4d72A:
5.84
2hdnD-4d72A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 5 TRP A 910
ALA A 913
LEU A 909
ALA A 919
 None
 1.17A 2jstA-4d72A:
undetectable
2jstB-4d72A:
undetectable		 2jstA-4d72A:
8.53
2jstB-4d72A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 8 LEU A 692
LEU A 685
PRO A 438
GLY A 717
 None
 0.81A 2po5A-4d72A:
undetectable		 2po5A-4d72A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZE2_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		5 / 10 PRO A 433
ILE A 428
VAL A 475
TYR A 473
TYR A 584
 None
 1.39A 2ze2A-4d72A:
0.3		 2ze2A-4d72A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		5 / 12 PHE A 493
TYR A 548
LEU A 551
LEU A 536
LEU A 459
 None
 1.40A 3adxA-4d72A:
undetectable		 3adxA-4d72A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 5 ASN A 591
ALA A 595
GLY A 593
TYR A 560
 None
None
None
NAG  A2009 (-4.6A)
 1.06A 3bcrA-4d72A:
2.8		 3bcrA-4d72A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 591
ALA A 595
GLY A 593
TYR A 560
 None
None
None
NAG  A2009 (-4.6A)
 1.03A 3dd1A-4d72A:
undetectable		 3dd1A-4d72A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 591
ALA A 595
GLY A 593
TYR A 560
 None
None
None
NAG  A2009 (-4.6A)
 1.04A 3dd1B-4d72A:
undetectable		 3dd1B-4d72A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 591
ALA A 595
GLY A 593
TYR A 560
 None
None
None
NAG  A2009 (-4.6A)
 1.05A 3ddsA-4d72A:
undetectable		 3ddsA-4d72A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 591
ALA A 595
GLY A 593
TYR A 560
 None
None
None
NAG  A2009 (-4.6A)
 1.04A 3ddsB-4d72A:
undetectable		 3ddsB-4d72A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 591
ALA A 595
GLY A 593
TYR A 560
 None
None
None
NAG  A2009 (-4.6A)
 1.05A 3ddwA-4d72A:
undetectable		 3ddwA-4d72A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 591
ALA A 595
GLY A 593
TYR A 560
 None
None
None
NAG  A2009 (-4.6A)
 1.05A 3ddwB-4d72A:
0.3		 3ddwB-4d72A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 478
LEU A 439
LEU A 483
ASP A 482
THR A 523
 None
None
None
None
FUC  A2007 (-2.8A)
 1.35A 3gwuA-4d72A:
undetectable		 3gwuA-4d72A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		3 / 3 SER A 559
GLY A 525
SER A 556
 None
 0.68A 3loqA-4d72A:
2.4		 3loqA-4d72A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 5 GLY A 766
LYS A 767
GLU A 777
GLY A 764
 EDO  A2012 (-3.9A)
None
None
None
 1.04A 3onnA-4d72A:
undetectable		 3onnA-4d72A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_2
(RIBOFLAVIN UPTAKE
PROTEIN)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 4 TYR A 855
ASN A 996
ASN A 898
PHE A 853
 None
 1.44A 3p5nA-4d72A:
0.0		 3p5nA-4d72A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		5 / 12 PHE A 821
TYR A 782
LEU A 831
ALA A 792
VAL A 754
 None
 0.99A 3rukA-4d72A:
undetectable		 3rukA-4d72A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 5 ILE A 596
THR A 636
THR A 635
SER A 638
 None
 1.15A 3snfA-4d72A:
undetectable		 3snfA-4d72A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 8 THR A 904
GLY A 995
PHE A 902
SER A 993
 None
 0.97A 3tzfB-4d72A:
11.9		 3tzfB-4d72A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		3 / 3 PRO A 743
TYR A 700
GLY A 704
 None
 0.60A 4g2zA-4d72A:
undetectable		 4g2zA-4d72A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 8 LEU A 692
PRO A 438
VAL A 718
GLY A 717
 None
 0.99A 4klrB-4d72A:
undetectable		 4klrB-4d72A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 845
PHE A 880
LEU A 899
PHE A 999
MET A 876
 None
 1.05A 4kykA-4d72A:
undetectable
4kykB-4d72A:
undetectable		 4kykA-4d72A:
17.98
4kykB-4d72A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 ASN A 856
VAL A 859
GLU A 861
ARG A 776
 None
 1.18A 4mv7A-4d72A:
undetectable		 4mv7A-4d72A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 PHE A 733
GLU A 695
MET A 656
ILE A 730
 None
 1.45A 4nosA-4d72A:
undetectable
4nosB-4d72A:
undetectable		 4nosA-4d72A:
20.36
4nosB-4d72A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		5 / 12 TYR A 494
ILE A 541
GLY A 553
PHE A 493
THR A 460
 None
 1.11A 5eslA-4d72A:
undetectable		 5eslA-4d72A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ILE A 939
TYR A 938
PHE A 944
THR A 969
 None
 1.30A 5g08A-4d72A:
undetectable		 5g08A-4d72A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		5 / 12 TYR A 494
ILE A 541
GLY A 553
PHE A 493
THR A 460
 None
 1.03A 5jlcA-4d72A:
undetectable		 5jlcA-4d72A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		3 / 3 SER A 559
ALA A 524
THR A 531
 None
FUC  A2007 ( 4.0A)
None
 0.65A 5n0xB-4d72A:
undetectable		 5n0xB-4d72A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		5 / 9 GLY A 867
VAL A 878
GLU A 879
ASP A 842
GLY A 841
 None
 1.32A 5zniA-4d72A:
undetectable		 5zniA-4d72A:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		5 / 12 GLU A 637
PHE A 623
PHE A 733
PRO A 433
ILE A 428
 None
 1.35A 6becA-4d72A:
undetectable
6becB-4d72A:
undetectable
6becC-4d72A:
undetectable		 6becA-4d72A:
23.23
6becB-4d72A:
23.23
6becC-4d72A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ASP A 657
GLN A 590
GLU A 710
THR A 520
 None
None
FUC  A2007 ( 2.9A)
None
 0.96A 6djzA-4d72A:
undetectable		 6djzA-4d72A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		5 / 11 ALA A 524
TYR A 440
ASP A 657
GLU A 710
THR A 520
 FUC  A2007 ( 4.0A)
FUC  A2007 (-4.4A)
None
FUC  A2007 ( 2.9A)
None
 1.22A 6dk1C-4d72A:
undetectable		 6dk1C-4d72A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4d72 GLYCOSIDE HYDROLASE
(Streptococcus
pneumoniae) 		5 / 12 ASN A 591
PRO A 794
ILE A 793
VAL A 796
PHE A 621
 None
 1.47A 6j21A-4d72A:
undetectable		 6j21A-4d72A:
20.99