SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d74'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OKX_A_SAMA201_0 (YAEB-LIKE PROTEIN RPA0152)	4d74	PROTEIN-TYROSINE-PHO SPHATASE AMSI (Erwinia amylovora)	5 / 12	LEU A 68 HIS A 63 GLY A 19 THR A 18 CYH A 9	None None None None SO4 A1145 (-3.2A)	1.35A	3okxA-4d74A: undetectable	3okxA-4d74A: 23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OKX_B_SAMB201_1 (YAEB-LIKE PROTEIN RPA0152)	4d74	PROTEIN-TYROSINE-PHO SPHATASE AMSI (Erwinia amylovora)	5 / 12	LEU A 68 HIS A 63 GLY A 19 THR A 18 CYH A 9	None None None None SO4 A1145 (-3.2A)	1.33A	3okxB-4d74A: undetectable	3okxB-4d74A: 23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HHJ_A_GLYA403_0 (RETRON-TYPE REVERSE TRANSCRIPTASE)	4d74	PROTEIN-TYROSINE-PHO SPHATASE AMSI (Erwinia amylovora)	4 / 4	LEU A 60 LEU A 22 GLY A 19 GLU A 20	None	1.23A	5hhjA-4d74A: undetectable	5hhjA-4d74A: 18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VEU_B_RITB602_1 (CYTOCHROME P450 3A5)	4d74	PROTEIN-TYROSINE-PHO SPHATASE AMSI (Erwinia amylovora)	5 / 12	LEU A 37 ALA A 65 ALA A 33 ILE A 32 GLY A 19	None	1.05A	5veuB-4d74A: undetectable	5veuB-4d74A: 16.95

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3OKX_A_SAMA201_0","YAEB-LIKE PROTEIN RPA0152","4d74","PROTEIN-TYROSINE-PHOSPHATASE AMSI","Erwinia amylovora",5,"LEU A  68;HIS A  63;GLY A  19;THR A  18;CYH A   9","None;None;None;None;SO4 A1145 (-3.2A)","1.35A","3okxA-4d74A:undetectable","3okxA-4d74A:23.78"],["3OKX_B_SAMB201_1","YAEB-LIKE PROTEIN RPA0152","4d74","PROTEIN-TYROSINE-PHOSPHATASE AMSI","Erwinia amylovora",5,"LEU A  68;HIS A  63;GLY A  19;THR A  18;CYH A   9","None;None;None;None;SO4 A1145 (-3.2A)","1.33A","3okxB-4d74A:undetectable","3okxB-4d74A:23.78"],["5HHJ_A_GLYA403_0","RETRON-TYPE REVERSE TRANSCRIPTASE","4d74","PROTEIN-TYROSINE-PHOSPHATASE AMSI","Erwinia amylovora",4,"LEU A  60;LEU A  22;GLY A  19;GLU A  20","None","1.23A","5hhjA-4d74A:undetectable","5hhjA-4d74A:18.06"],["5VEU_B_RITB602_1","CYTOCHROME P450 3A5","4d74","PROTEIN-TYROSINE-PHOSPHATASE AMSI","Erwinia amylovora",5,"LEU A  37;ALA A  65;ALA A  33;ILE A  32;GLY A  19","None","1.05A","5veuB-4d74A:undetectable","5veuB-4d74A:16.95"]]