SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d7a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 4d7a TRNA
THREONYLCARBAMOYLADE
NOSINE DEHYDRATASE
(Escherichia
coli) 		5 / 12 ILE A  93
ASN A  97
CYH A 100
GLU A  47
ARG A  51
 None
 1.15A 2bxfA-4d7aA:
undetectable		 2bxfA-4d7aA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4d7a TRNA
THREONYLCARBAMOYLADE
NOSINE DEHYDRATASE
(Escherichia
coli) 		5 / 11 VAL A 109
LEU A 181
CYH A 142
VAL A  36
ILE A 129
 AMP  A 401 (-4.2A)
None
None
AMP  A 401 (-4.8A)
AMP  A 401 (-4.1A)
 1.00A 2uxoB-4d7aA:
undetectable		 2uxoB-4d7aA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 4d7a TRNA
THREONYLCARBAMOYLADE
NOSINE DEHYDRATASE
(Escherichia
coli) 		5 / 12 ILE A 129
ALA A 128
THR A 152
VAL A 150
LEU A 149
 AMP  A 401 (-4.1A)
None
None
None
GOL  A 502 (-4.7A)
 1.14A 3a51E-4d7aA:
undetectable		 3a51E-4d7aA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4d7a TRNA
THREONYLCARBAMOYLADE
NOSINE DEHYDRATASE
(Escherichia
coli) 		5 / 11 ALA A 240
ALA A  45
GLY A 249
THR A 247
ALA A 246
 None
 1.17A 3mg0V-4d7aA:
undetectable
3mg0W-4d7aA:
undetectable		 3mg0V-4d7aA:
21.20
3mg0W-4d7aA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4d7a TRNA
THREONYLCARBAMOYLADE
NOSINE DEHYDRATASE
(Escherichia
coli) 		4 / 6 ILE A  38
CYH A 142
LEU A 149
ILE A 126
 None
None
GOL  A 502 (-4.7A)
None
 0.87A 4asdA-4d7aA:
undetectable		 4asdA-4d7aA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4d7a TRNA
THREONYLCARBAMOYLADE
NOSINE DEHYDRATASE
(Escherichia
coli) 		4 / 7 THR A 152
VAL A 166
ASP A 202
VAL A 204
 None
GOL  A 501 ( 4.8A)
GOL  A 502 (-4.1A)
None
 0.78A 4cp4A-4d7aA:
undetectable		 4cp4A-4d7aA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 4d7a TRNA
THREONYLCARBAMOYLADE
NOSINE DEHYDRATASE
(Escherichia
coli) 		6 / 10 LEU A 138
ASP A 127
GLY A  39
ILE A  38
VAL A 109
ILE A 129
 None
None
AMP  A 401 (-3.2A)
None
AMP  A 401 (-4.2A)
AMP  A 401 (-4.1A)
 1.28A 4dqfB-4d7aA:
undetectable		 4dqfB-4d7aA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4d7a TRNA
THREONYLCARBAMOYLADE
NOSINE DEHYDRATASE
(Escherichia
coli) 		5 / 12 GLY A 153
GLY A 154
SER A 206
ALA A 252
VAL A  41
 None
None
K  A 301 (-4.4A)
None
None
 1.00A 4htfB-4d7aA:
undetectable		 4htfB-4d7aA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 4d7a TRNA
THREONYLCARBAMOYLADE
NOSINE DEHYDRATASE
(Escherichia
coli) 		4 / 4 ILE A 139
VAL A 150
VAL A 201
ARG A 143
 None
None
GOL  A 502 (-3.7A)
None
 1.24A 4m6tA-4d7aA:
undetectable		 4m6tA-4d7aA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4d7a TRNA
THREONYLCARBAMOYLADE
NOSINE DEHYDRATASE
(Escherichia
coli) 		4 / 4 VAL A 125
ILE A 139
ASN A 145
VAL A 114
 None
 1.34A 5ajqA-4d7aA:
undetectable		 5ajqA-4d7aA:
18.60