SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d7e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		3 / 3 TRP A  91
VAL A  96
TRP A 104
 None
 1.31A 1c4dC-4d7eA:
undetectable
1c4dD-4d7eA:
undetectable		 1c4dC-4d7eA:
4.17
1c4dD-4d7eA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		3 / 3 TRP A 104
VAL A  96
TRP A  91
 None
 1.13A 1c4dC-4d7eA:
undetectable
1c4dD-4d7eA:
undetectable		 1c4dC-4d7eA:
4.17
1c4dD-4d7eA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 9 VAL A 332
ILE A 233
ALA A 209
SER A 207
LEU A 330
 None
 0.93A 1eqgA-4d7eA:
undetectable		 1eqgA-4d7eA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 11 VAL A 332
ILE A 233
ALA A 209
SER A 207
LEU A 330
 None
 0.95A 1eqgB-4d7eA:
undetectable		 1eqgB-4d7eA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 12 THR A 276
ILE A 212
GLY A 213
GLY A 215
HIS A 297
 None
 0.92A 2fk8A-4d7eA:
2.2		 2fk8A-4d7eA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 10 LEU A 165
VAL A  36
GLY A 135
THR A 162
ARG A 138
 None
 1.12A 2wd9C-4d7eA:
undetectable		 2wd9C-4d7eA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		3 / 3 VAL A  41
TRP A 117
TRP A  45
 None
None
FAD  A 500 (-4.4A)
 1.12A 2xdcC-4d7eA:
undetectable
2xdcD-4d7eA:
undetectable		 2xdcC-4d7eA:
4.17
2xdcD-4d7eA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		3 / 3 TRP A  45
VAL A  41
TRP A 117
 FAD  A 500 (-4.4A)
None
None
 1.19A 2xdcC-4d7eA:
undetectable
2xdcD-4d7eA:
undetectable		 2xdcC-4d7eA:
4.17
2xdcD-4d7eA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		3 / 3 TRP A  45
VAL A  41
TRP A 117
 FAD  A 500 (-4.4A)
None
None
 1.16A 2xdcE-4d7eA:
undetectable
2xdcF-4d7eA:
undetectable		 2xdcE-4d7eA:
4.17
2xdcF-4d7eA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		3 / 3 TRP A  45
VAL A  41
TRP A 117
 FAD  A 500 (-4.4A)
None
None
 1.16A 2y5mE-4d7eA:
undetectable
2y5mF-4d7eA:
undetectable		 2y5mE-4d7eA:
4.17
2y5mF-4d7eA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		3 / 3 TRP A  45
VAL A  41
TRP A 117
 FAD  A 500 (-4.4A)
None
None
 1.14A 2y6nC-4d7eA:
undetectable
2y6nD-4d7eA:
undetectable		 2y6nC-4d7eA:
4.17
2y6nD-4d7eA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		3 / 3 TRP A  45
VAL A  41
TRP A 117
 FAD  A 500 (-4.4A)
None
None
 1.16A 2y6nE-4d7eA:
undetectable
2y6nF-4d7eA:
undetectable		 2y6nE-4d7eA:
4.17
2y6nF-4d7eA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 12 ILE A 140
LEU A 380
ALA A 382
ILE A 367
LEU A 386
 None
 1.03A 3dauA-4d7eA:
undetectable		 3dauA-4d7eA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 9 ASP A 329
VAL A 331
ILE A 305
GLY A 307
PRO A 186
 None
 1.19A 3el4B-4d7eA:
undetectable		 3el4B-4d7eA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 10 ASP A 329
VAL A 331
ILE A 305
GLY A 307
PRO A 186
 None
 1.16A 3el5A-4d7eA:
undetectable		 3el5A-4d7eA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 12 SER A 237
GLY A 219
GLY A 279
HIS A 297
VAL A 235
 None
 0.81A 3f8wA-4d7eA:
undetectable		 3f8wA-4d7eA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 12 SER A 237
GLY A 219
GLY A 279
HIS A 297
VAL A 235
 None
 0.89A 3f8wB-4d7eA:
undetectable		 3f8wB-4d7eA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 11 ALA A  17
VAL A 124
ILE A  66
ILE A  82
ILE A 128
 None
 0.99A 3lzvB-4d7eA:
undetectable		 3lzvB-4d7eA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 10 ALA A  17
VAL A 124
ILE A  66
ILE A  82
ILE A 128
 None
 0.93A 3nu6A-4d7eA:
undetectable		 3nu6A-4d7eA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 10 ALA A  17
VAL A 124
ILE A  66
ILE A  82
ILE A 128
 None
 0.97A 3nujA-4d7eA:
undetectable		 3nujA-4d7eA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		3 / 3 ASN A  79
ALA A  75
ARG A 413
 None
 0.69A 3tj7C-4d7eA:
undetectable
3tj7D-4d7eA:
undetectable		 3tj7C-4d7eA:
18.18
3tj7D-4d7eA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 12 ILE A 233
VAL A 332
LEU A 182
VAL A 302
LEU A 316
 None
 1.26A 3w68C-4d7eA:
undetectable		 3w68C-4d7eA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		3 / 3 VAL A  41
TRP A 117
TRP A  45
 None
None
FAD  A 500 (-4.4A)
 1.18A 3zq8A-4d7eA:
undetectable
3zq8B-4d7eA:
undetectable		 3zq8A-4d7eA:
4.17
3zq8B-4d7eA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		3 / 3 TRP A  45
VAL A 116
TRP A 117
 FAD  A 500 (-4.4A)
None
None
 0.90A 3zq8C-4d7eA:
undetectable
3zq8D-4d7eA:
undetectable		 3zq8C-4d7eA:
4.17
3zq8D-4d7eA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 12 ALA A  17
VAL A 124
ILE A  66
ILE A  82
ILE A 128
 None
 0.94A 4dqbA-4d7eA:
undetectable		 4dqbA-4d7eA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 12 ALA A  17
VAL A 124
ILE A  66
ILE A  82
ILE A 128
 None
 0.97A 4dqfA-4d7eA:
undetectable		 4dqfA-4d7eA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		4 / 5 ARG A 304
THR A 303
THR A 315
ASP A 323
 None
 1.31A 4oltB-4d7eA:
undetectable		 4oltB-4d7eA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 12 ILE A 140
LEU A 380
ALA A 382
ILE A 367
LEU A 386
 None
 1.06A 4psyA-4d7eA:
undetectable		 4psyA-4d7eA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 11 ALA A  17
VAL A 124
ILE A  66
ILE A  82
ILE A 128
 None
 0.97A 4rvjA-4d7eA:
undetectable		 4rvjA-4d7eA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 11 ALA A  17
VAL A 124
ILE A  66
ILE A  82
ILE A 128
 None
 0.97A 4rvjC-4d7eA:
undetectable		 4rvjC-4d7eA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 10 ILE A  66
GLY A  10
LEU A 121
TRP A  45
LEU A 401
 None
FAD  A 500 (-3.4A)
None
FAD  A 500 (-4.4A)
FAD  A 500 (-3.8A)
 1.32A 5fhzC-4d7eA:
undetectable		 5fhzC-4d7eA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		4 / 6 PHE A 194
VAL A 332
MET A 230
ILE A 233
 None
 1.15A 5iwuA-4d7eA:
undetectable		 5iwuA-4d7eA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 12 SER A 237
VAL A 280
ALA A 334
ALA A 218
GLY A 213
 None
 1.31A 5tzoA-4d7eA:
undetectable		 5tzoA-4d7eA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		4 / 5 HIS A  71
GLU A  84
LEU A  23
VAL A  22
 None
 1.11A 6bc9A-4d7eA:
undetectable		 6bc9A-4d7eA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 12 ALA A  17
VAL A 124
ILE A  66
ILE A  82
ILE A 128
 None
 1.00A 6dh3B-4d7eA:
undetectable		 6dh3B-4d7eA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4d7e L-LYS MONOOXYGENASE
(Nocardia
farcinica) 		5 / 11 ASP A  53
GLY A 214
SER A 237
ALA A 240
VAL A 211
 None
 1.37A 6hu9A-4d7eA:
undetectable
6hu9E-4d7eA:
undetectable
6hu9I-4d7eA:
undetectable		 6hu9A-4d7eA:
21.85
6hu9E-4d7eA:
18.07
6hu9I-4d7eA:
6.53