SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 4d7k SAM-DEPENDENT
METHYLTRANSFERASES
(Streptomyces
davaonensis) 		4 / 7 VAL A 208
LEU A 250
VAL A 253
LEU A 241
 None
 0.68A 1cqpA-4d7kA:
undetectable
1cqpB-4d7kA:
undetectable		 1cqpA-4d7kA:
19.77
1cqpB-4d7kA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4d7k SAM-DEPENDENT
METHYLTRANSFERASES
(Streptomyces
davaonensis) 		5 / 10 PHE A 174
SER A 173
LEU A 284
VAL A 249
VAL A 339
 None
 1.49A 1q23E-4d7kA:
undetectable		 1q23E-4d7kA:
19.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 4d7k SAM-DEPENDENT
METHYLTRANSFERASES
(Streptomyces
davaonensis) 		4 / 8 ASP A 184
GLY A 187
GLY A 190
LEU A 193
 None
 0.39A 1qzzA-4d7kA:
20.8		 1qzzA-4d7kA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 4d7k SAM-DEPENDENT
METHYLTRANSFERASES
(Streptomyces
davaonensis) 		6 / 12 GLY A 186
GLY A 187
GLY A 188
ASP A 236
PHE A 237
TRP A 257
 None
 1.48A 1qzzA-4d7kA:
21.0		 1qzzA-4d7kA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4d7k SAM-DEPENDENT
METHYLTRANSFERASES
(Streptomyces
davaonensis) 		6 / 12 GLY A 295
GLY A 292
ASP A 299
PHE A 162
SER A 286
HIS A 310
 None
 1.47A 1wg8B-4d7kA:
11.0		 1wg8B-4d7kA:
25.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 4d7k SAM-DEPENDENT
METHYLTRANSFERASES
(Streptomyces
davaonensis) 		6 / 12 GLY A 186
GLY A 187
GLY A 188
ASP A 236
PHE A 237
TRP A 257
 None
 1.43A 1xdsA-4d7kA:
6.4		 1xdsA-4d7kA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 4d7k SAM-DEPENDENT
METHYLTRANSFERASES
(Streptomyces
davaonensis) 		6 / 12 GLY A 186
GLY A 187
GLY A 188
ASP A 236
PHE A 237
TRP A 257
 None
 1.39A 1xdsB-4d7kA:
22.0		 1xdsB-4d7kA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 4d7k SAM-DEPENDENT
METHYLTRANSFERASES
(Streptomyces
davaonensis) 		5 / 12 LEU A  92
ASP A  40
THR A 105
THR A 106
GLY A 103
 None
 1.21A 2uvnA-4d7kA:
undetectable		 2uvnA-4d7kA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4d7k SAM-DEPENDENT
METHYLTRANSFERASES
(Streptomyces
davaonensis) 		3 / 3 ASP A  91
LEU A  92
GLN A 164
 None
 0.67A 3g4lA-4d7kA:
undetectable		 3g4lA-4d7kA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4d7k SAM-DEPENDENT
METHYLTRANSFERASES
(Streptomyces
davaonensis) 		4 / 5 SER A  83
THR A  48
GLU A  85
ASP A  91
 None
 1.39A 3tm4A-4d7kA:
14.2		 3tm4A-4d7kA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4d7k SAM-DEPENDENT
METHYLTRANSFERASES
(Streptomyces
davaonensis) 		4 / 5 SER A  83
THR A  48
GLU A  85
ASP A  91
 None
 1.38A 3tm4B-4d7kA:
14.2		 3tm4B-4d7kA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4d7k SAM-DEPENDENT
METHYLTRANSFERASES
(Streptomyces
davaonensis) 		5 / 12 ASP A 184
GLY A 186
ASP A 209
ASP A 236
TRP A 257
 None
 1.39A 4pghB-4d7kA:
23.8		 4pghB-4d7kA:
25.45