SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d7l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Corynebacterium
diphtheriae) 		4 / 8 THR A  63
PRO A  64
GLY A  65
THR A 107
 None
 0.48A 1h4oB-4d7lA:
undetectable		 1h4oB-4d7lA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Corynebacterium
diphtheriae) 		4 / 8 THR A  63
PRO A  64
GLY A  65
THR A 107
 None
 0.54A 1oc3A-4d7lA:
undetectable		 1oc3A-4d7lA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Corynebacterium
diphtheriae) 		5 / 12 ILE A 172
ILE A  48
VAL A 157
ILE A 176
ILE A  46
 None
 1.17A 1r5lA-4d7lA:
undetectable		 1r5lA-4d7lA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Corynebacterium
diphtheriae) 		5 / 12 TYR A  47
ALA A 190
SER A  70
VAL A  71
TYR A  53
 None
None
None
None
CAC  A1220 (-4.2A)
 1.00A 2p16A-4d7lA:
undetectable		 2p16A-4d7lA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Corynebacterium
diphtheriae) 		5 / 11 THR A 174
ILE A 176
ILE A  48
ALA A 115
VAL A 157
 None
 1.15A 2qhfA-4d7lA:
undetectable		 2qhfA-4d7lA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Corynebacterium
diphtheriae) 		5 / 12 GLY A  55
ALA A  56
ILE A  48
VAL A  99
ILE A  50
 None
 0.94A 2rkgB-4d7lA:
undetectable		 2rkgB-4d7lA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Corynebacterium
diphtheriae) 		4 / 4 ARG A  90
GLN A 134
PHE A  73
LEU A  17
 None
 1.43A 3abkC-4d7lA:
0.2		 3abkC-4d7lA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Corynebacterium
diphtheriae) 		4 / 5 ARG A  90
GLN A 134
PHE A  73
LEU A  17
 None
 1.41A 3ablC-4d7lA:
undetectable
3ablJ-4d7lA:
undetectable		 3ablC-4d7lA:
19.85
3ablJ-4d7lA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Corynebacterium
diphtheriae) 		5 / 10 GLY A  55
ALA A  56
ILE A  48
VAL A  99
ILE A  50
 None
 0.89A 3s43B-4d7lA:
undetectable		 3s43B-4d7lA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Corynebacterium
diphtheriae) 		4 / 6 GLY A  76
LEU A 179
TYR A 140
GLU A 175
 None
 1.10A 3w9tB-4d7lA:
undetectable		 3w9tB-4d7lA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Corynebacterium
diphtheriae) 		4 / 6 GLY A  76
LEU A 179
TYR A 140
GLU A 175
 None
 1.11A 3w9tE-4d7lA:
undetectable		 3w9tE-4d7lA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Corynebacterium
diphtheriae) 		4 / 6 GLY A  76
LEU A 179
TYR A 140
GLU A 175
 None
 1.12A 3w9tF-4d7lA:
undetectable		 3w9tF-4d7lA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Corynebacterium
diphtheriae) 		4 / 5 ILE A  96
ARG A 136
TYR A 140
GLU A 175
 None
 1.14A 4zzcE-4d7lA:
undetectable		 4zzcE-4d7lA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Corynebacterium
diphtheriae) 		4 / 6 LEU A 177
THR A 182
GLY A  75
ARG A 136
 None
 1.27A 6gtqB-4d7lA:
undetectable
6gtqD-4d7lA:
undetectable		 6gtqB-4d7lA:
21.54
6gtqD-4d7lA:
10.75