SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d7q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 8 VAL A 126
SER A 127
ASN A 171
ASP A 130
 None
None
None
PEG  A1354 (-3.5A)
 1.16A 1hwiB-4d7qA:
1.7		 1hwiB-4d7qA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 7 VAL A 126
SER A 127
ASN A 171
ASP A 130
 None
None
None
PEG  A1354 (-3.5A)
 1.22A 1hwiC-4d7qA:
undetectable		 1hwiC-4d7qA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 7 VAL A 126
SER A 127
ASN A 171
ASP A 130
 None
None
None
PEG  A1354 (-3.5A)
 1.22A 1hwiD-4d7qA:
1.5		 1hwiD-4d7qA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 8 VAL A 126
SER A 127
ASN A 171
ASP A 130
 None
None
None
PEG  A1354 (-3.5A)
 1.14A 1hwkA-4d7qA:
1.8		 1hwkA-4d7qA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 8 VAL A 126
SER A 127
ASN A 171
ASP A 130
 None
None
None
PEG  A1354 (-3.5A)
 1.13A 1hwkC-4d7qA:
1.8		 1hwkC-4d7qA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 8 VAL A 126
SER A 127
ASN A 171
ASP A 130
 None
None
None
PEG  A1354 (-3.5A)
 1.14A 1hwkD-4d7qA:
1.8		 1hwkD-4d7qA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 5 PHE A 114
GLY A  90
THR A 139
PHE A  87
 None
 1.21A 1icuC-4d7qA:
undetectable
1icuD-4d7qA:
undetectable		 1icuC-4d7qA:
22.41
1icuD-4d7qA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		3 / 3 PHE A  16
TYR A 331
PRO A  20
 None
GOL  A1350 ( 2.2A)
NO3  A1348 (-4.0A)
 1.12A 1mcnA-4d7qA:
undetectable
1mcnB-4d7qA:
undetectable
1mcnP-4d7qA:
undetectable		 1mcnA-4d7qA:
18.62
1mcnB-4d7qA:
18.62
1mcnP-4d7qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 6 ALA A 314
LEU A 312
SER A 309
SER A 306
 None
 1.02A 1tz8C-4d7qA:
undetectable
1tz8D-4d7qA:
undetectable		 1tz8C-4d7qA:
15.99
1tz8D-4d7qA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 6 ASN A 207
ASN A 206
ILE A 294
GLN A 204
 None
 1.23A 2hkkA-4d7qA:
undetectable		 2hkkA-4d7qA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 5 PRO A 201
PRO A 101
ILE A 107
GLY A 102
 NO3  A1348 ( 4.6A)
None
None
None
 1.03A 2jkjD-4d7qA:
undetectable		 2jkjD-4d7qA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 5 PRO A 201
PRO A 101
ILE A 107
GLY A 102
 NO3  A1348 ( 4.6A)
None
None
None
 1.02A 2jkjF-4d7qA:
undetectable		 2jkjF-4d7qA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		5 / 10 SER A 127
ALA A 131
ASN A 128
ALA A 129
ALA A 132
 None
None
None
PEG  A1354 (-3.1A)
None
 1.19A 2r2vC-4d7qA:
undetectable
2r2vF-4d7qA:
undetectable
2r2vG-4d7qA:
undetectable		 2r2vC-4d7qA:
6.53
2r2vF-4d7qA:
6.53
2r2vG-4d7qA:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 7 ILE A 229
LEU A 236
PHE A 233
PHE A 320
 None
 0.94A 2vctD-4d7qA:
undetectable		 2vctD-4d7qA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 5 PHE A 286
PHE A 196
LEU A 194
PHE A 192
 None
EPE  A1347 (-3.5A)
None
None
 1.25A 2y69P-4d7qA:
undetectable
2y69W-4d7qA:
undetectable		 2y69P-4d7qA:
19.79
2y69W-4d7qA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		3 / 3 HIS A   2
GLU A  41
HIS A   1
 None
 0.87A 3ba0A-4d7qA:
undetectable		 3ba0A-4d7qA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		5 / 10 ILE A 316
ILE A 274
VAL A 276
GLY A 260
LEU A 298
 None
 1.13A 3em0A-4d7qA:
1.2		 3em0A-4d7qA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 6 GLN A 296
ILE A 294
SER A  64
SER A  63
 GOL  A1349 (-3.4A)
None
GOL  A1350 (-2.7A)
None
 1.33A 3pmzD-4d7qA:
undetectable		 3pmzD-4d7qA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 6 PHE A 255
PHE A 251
ALA A 136
LEU A 166
 None
 1.00A 4ejgD-4d7qA:
undetectable		 4ejgD-4d7qA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 5 LEU A 110
PHE A 114
LEU A 100
PHE A 196
 None
None
None
EPE  A1347 (-3.5A)
 1.18A 5iy5P-4d7qA:
undetectable
5iy5W-4d7qA:
undetectable		 5iy5P-4d7qA:
20.54
5iy5W-4d7qA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		3 / 3 LYS A  28
GLN A  70
ASN A  69
 None
None
GOL  A1350 (-2.7A)
 1.01A 5l2tA-4d7qA:
undetectable		 5l2tA-4d7qA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 6 LEU A 110
PHE A 114
LEU A 100
PHE A 196
 None
None
None
EPE  A1347 (-3.5A)
 1.13A 5w97C-4d7qA:
undetectable
5w97J-4d7qA:
undetectable		 5w97C-4d7qA:
19.79
5w97J-4d7qA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 5 LEU A 110
PHE A 114
LEU A 100
PHE A 196
 None
None
None
EPE  A1347 (-3.5A)
 1.17A 5x1fC-4d7qA:
undetectable
5x1fJ-4d7qA:
undetectable		 5x1fC-4d7qA:
19.79
5x1fJ-4d7qA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 5 ASP A 174
ARG A 167
GLN A 138
MET A 141
 None
 1.43A 5zrfB-4d7qA:
undetectable		 5zrfB-4d7qA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		5 / 10 THR A 215
ASP A 213
ILE A 316
PHE A 233
ILE A 205
 None
 1.11A 6ebpD-4d7qA:
undetectable		 6ebpD-4d7qA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 5 ALA A 104
TYR A 258
GLN A 296
ILE A 294
 None
None
GOL  A1349 (-3.4A)
None
 1.44A 6g9bA-4d7qA:
undetectable
6g9bB-4d7qA:
undetectable		 6g9bA-4d7qA:
12.90
6g9bB-4d7qA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 4d7q RALF,
PROLINE/BETAINE
TRANSPORTER
(Legionella
pneumophila;
Rickettsia
prowazekii) 		5 / 11 THR A 215
ASP A 213
ILE A 316
PHE A 233
ILE A 205
 None
 1.04A 6gp2A-4d7qA:
undetectable		 6gp2A-4d7qA:
15.29