SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d7r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4d7r PROLINE/BETAINE
TRANSPORTER, RALF
(Legionella
pneumophila;
Rickettsia
prowazekii) 		5 / 12 ILE A 273
LEU A 262
VAL A 239
ILE A 235
ILE A 294
 None
 0.77A 1oipA-4d7rA:
undetectable		 1oipA-4d7rA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4d7r PROLINE/BETAINE
TRANSPORTER, RALF
(Legionella
pneumophila;
Rickettsia
prowazekii) 		5 / 12 THR A 213
VAL A 275
GLY A 234
ILE A 342
TYR A 335
 None
 1.27A 1xvaA-4d7rA:
undetectable		 1xvaA-4d7rA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4d7r PROLINE/BETAINE
TRANSPORTER, RALF
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 5 PRO A 199
PRO A  98
ILE A 104
GLY A  99
 None
 1.09A 2jkjD-4d7rA:
undetectable		 2jkjD-4d7rA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4d7r PROLINE/BETAINE
TRANSPORTER, RALF
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 5 PRO A 199
PRO A  98
ILE A 104
GLY A  99
 None
 1.08A 2jkjF-4d7rA:
undetectable		 2jkjF-4d7rA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4d7r PROLINE/BETAINE
TRANSPORTER, RALF
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 8 LEU A 217
PHE A 313
ALA A 309
ALA A 310
 None
 0.79A 3ax9B-4d7rA:
undetectable		 3ax9B-4d7rA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4d7r PROLINE/BETAINE
TRANSPORTER, RALF
(Legionella
pneumophila;
Rickettsia
prowazekii) 		4 / 4 ILE A 260
GLN A 102
ILE A 294
LEU A 250
 None
 1.14A 3dzyD-4d7rA:
undetectable		 3dzyD-4d7rA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4d7r PROLINE/BETAINE
TRANSPORTER, RALF
(Legionella
pneumophila;
Rickettsia
prowazekii) 		3 / 3 ASN A 227
ASP A 237
ARG A 346
 None
 0.93A 3k13C-4d7rA:
undetectable		 3k13C-4d7rA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4d7r PROLINE/BETAINE
TRANSPORTER, RALF
(Legionella
pneumophila;
Rickettsia
prowazekii) 		3 / 3 LYS A 188
PRO A 189
LYS A 191
 None
 1.18A 5y9yA-4d7rA:
undetectable		 5y9yA-4d7rA:
21.00