SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d7u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		5 / 12 GLY A 213
GLY A 205
TYR A 204
ILE A 201
LEU A 151
 None
 1.08A 1p91B-4d7uA:
undetectable		 1p91B-4d7uA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		4 / 6 GLY A  85
PRO A  86
ILE A 219
GLY A 114
 None
 0.84A 1usqB-4d7uA:
undetectable		 1usqB-4d7uA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		4 / 6 GLY A  85
PRO A  86
ILE A 219
GLY A 114
 None
 0.83A 1usqC-4d7uA:
undetectable		 1usqC-4d7uA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		4 / 6 GLY A  85
PRO A  86
ILE A 219
GLY A 114
 None
 0.83A 1usqD-4d7uA:
undetectable		 1usqD-4d7uA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		4 / 6 GLY A  85
PRO A  86
ILE A 219
GLY A 114
 None
 0.83A 1usqE-4d7uA:
undetectable		 1usqE-4d7uA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		4 / 7 GLY A  85
PRO A  86
ILE A 219
GLY A 114
 None
 0.80A 1usqF-4d7uA:
undetectable		 1usqF-4d7uA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		4 / 6 GLY A  85
PRO A  86
ILE A 219
GLY A 114
 None
 0.84A 2jklB-4d7uA:
undetectable		 2jklB-4d7uA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		4 / 7 GLY A  85
PRO A  86
ILE A 219
GLY A 114
 None
 0.84A 2jklE-4d7uA:
undetectable		 2jklE-4d7uA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		5 / 10 ALA A  97
ILE A 172
ILE A 140
PRO A 137
THR A 100
 None
 1.17A 3clbD-4d7uA:
undetectable		 3clbD-4d7uA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3COT_A_STRA1501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		4 / 7 TYR A 192
GLU A 150
TYR A 217
TRP A 120
 None
 1.45A 3cotA-4d7uA:
undetectable		 3cotA-4d7uA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		5 / 12 VAL A 110
VAL A 186
VAL A  58
ILE A 172
MET A 136
 None
 1.22A 3dl9A-4d7uA:
undetectable		 3dl9A-4d7uA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		5 / 10 ALA A  97
ILE A 172
ILE A 140
PRO A 137
THR A 100
 None
 1.19A 3hbbD-4d7uA:
undetectable		 3hbbD-4d7uA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		5 / 5 HIS A   1
ALA A  80
HIS A  83
GLN A 164
TYR A 166
 CU  A 300 (-3.0A)
None
CU  A 300 (-3.1A)
CU  A 300 (-4.3A)
None
 0.83A 4gboA-4d7uA:
7.8		 4gboA-4d7uA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		5 / 5 HIS A   1
ALA A  80
HIS A  83
GLN A 164
TYR A 166
 CU  A 300 (-3.0A)
None
CU  A 300 (-3.1A)
CU  A 300 (-4.3A)
None
 1.03A 4gboB-4d7uA:
7.9		 4gboB-4d7uA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		4 / 5 HIS A   1
HIS A 155
GLN A 164
TYR A 166
 CU  A 300 (-3.0A)
None
CU  A 300 (-4.3A)
None
 1.00A 4gboB-4d7uA:
7.9		 4gboB-4d7uA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		5 / 12 VAL A  52
ASN A  10
GLY A  55
ASP A 135
GLY A  59
 None
 1.29A 4pevB-4d7uA:
undetectable		 4pevB-4d7uA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		3 / 3 TYR A 217
GLY A  85
PRO A  86
 None
 0.71A 4qwpA-4d7uA:
undetectable		 4qwpA-4d7uA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		4 / 8 ILE A 219
PRO A  86
ILE A 167
LEU A 224
 None
 0.99A 5ieoA-4d7uA:
undetectable		 5ieoA-4d7uA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		5 / 5 HIS A   1
ALA A  80
HIS A  83
GLN A 164
TYR A 166
 CU  A 300 (-3.0A)
None
CU  A 300 (-3.1A)
CU  A 300 (-4.3A)
None
 0.80A 5uizA-4d7uA:
7.9		 5uizA-4d7uA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_B_CUB301_0
(AA10A)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		4 / 4 HIS A   1
HIS A  83
GLN A 164
TYR A 166
 CU  A 300 (-3.0A)
CU  A 300 (-3.1A)
CU  A 300 (-4.3A)
None
 0.89A 5uizB-4d7uA:
7.9		 5uizB-4d7uA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_B_CUB301_0
(AA10A)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		4 / 4 HIS A   1
HIS A 155
GLN A 164
TYR A 166
 CU  A 300 (-3.0A)
None
CU  A 300 (-4.3A)
None
 1.01A 5uizB-4d7uA:
7.9		 5uizB-4d7uA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4d7u ENDOGLUCANASE II
(Neurospora
crassa) 		4 / 5 PRO A 137
VAL A 110
GLY A  11
VAL A  52
 None
None
GOL  A1229 (-3.5A)
None
 1.09A 6ak3B-4d7uA:
undetectable		 6ak3B-4d7uA:
15.00