SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d86'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 11 CYH A 849
SER A 838
LEU A 837
ALA A 834
LEU A 833
 None
None
None
None
ADP  A1201 (-3.9A)
 1.49A 1hwkB-4d86A:
undetectable		 1hwkB-4d86A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 11 CYH A 849
SER A 838
LEU A 837
ALA A 834
LEU A 833
 None
None
None
None
ADP  A1201 (-3.9A)
 1.49A 1hwkA-4d86A:
undetectable		 1hwkA-4d86A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 11 CYH A 849
SER A 838
LEU A 837
ALA A 834
LEU A 833
 None
None
None
None
ADP  A1201 (-3.9A)
 1.48A 1hwkD-4d86A:
undetectable		 1hwkD-4d86A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 11 CYH A 849
SER A 838
LEU A 837
ALA A 834
LEU A 833
 None
None
None
None
ADP  A1201 (-3.9A)
 1.48A 1hwkC-4d86A:
undetectable		 1hwkC-4d86A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		4 / 5 LEU A1122
VAL A1030
TYR A1088
THR A1119
 None
 1.35A 1nw3A-4d86A:
undetectable		 1nw3A-4d86A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 12 LEU A 859
ILE A 921
SER A 904
ILE A 918
ILE A 878
 None
 1.30A 2efjA-4d86A:
undetectable		 2efjA-4d86A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		4 / 5 ALA A1131
ASN A1178
ILE A1179
ASP A1175
 ADP  A1202 (-4.4A)
ADP  A1202 (-4.1A)
None
ADP  A1202 (-3.7A)
 1.03A 2h4jA-4d86A:
undetectable		 2h4jA-4d86A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		4 / 4 VAL A1093
THR A1075
VAL A1069
GLY A1066
 None
 1.08A 2p2fB-4d86A:
undetectable		 2p2fB-4d86A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 11 LEU A1090
SER A1121
PHE A1129
VAL A1023
LEU A1170
 None
None
None
ADP  A1202 (-3.9A)
None
 1.38A 3a9eB-4d86A:
undetectable		 3a9eB-4d86A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 12 SER A 823
HIS A 829
LEU A 833
ILE A 918
LEU A 827
 None
None
ADP  A1201 (-3.9A)
None
None
 1.26A 3g9eA-4d86A:
undetectable		 3g9eA-4d86A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		4 / 7 VAL A 816
ILE A 957
TYR A 958
ILE A 918
 None
 0.91A 3hgxA-4d86A:
undetectable		 3hgxA-4d86A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		4 / 8 HIS A 879
VAL A 877
VAL A 818
ASP A 848
 None
 1.08A 3uy4A-4d86A:
2.8		 3uy4A-4d86A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		4 / 8 ARG A 899
TYR A 895
ARG A 892
ASP A1110
 None
 0.83A 4kr4C-4d86A:
undetectable		 4kr4C-4d86A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 12 LEU A 804
VAL A 806
LEU A 930
ILE A 941
ALA A 940
 None
 1.08A 4ltwA-4d86A:
undetectable		 4ltwA-4d86A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 12 LEU A 804
LEU A 959
ILE A 957
LEU A 954
ILE A 916
 None
 1.02A 4y0rA-4d86A:
undetectable		 4y0rA-4d86A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A
HETERODISULFIDE
REDUCTASE, SUBUNIT B
HETERODISULFIDE
REDUCTASE, SUBUNIT C)		 4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		4 / 4 GLU A1146
ARG A1188
ARG A1189
GLU A1185
 None
 1.43A 5odcB-4d86A:
0.0
5odcC-4d86A:
undetectable
5odcG-4d86A:
0.0		 5odcB-4d86A:
23.15
5odcC-4d86A:
18.60
5odcG-4d86A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		3 / 3 ARG A1113
LYS A1154
ARG A 898
 None
 1.14A 6c06D-4d86A:
undetectable		 6c06D-4d86A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		3 / 3 ASP A1038
SER A1034
SER A1047
 None
ADP  A1202 (-2.6A)
None
 0.82A 6mxtA-4d86A:
undetectable		 6mxtA-4d86A:
22.99