SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d8m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		4 / 8 LEU A 456
TYR A 536
SER A 345
GLU A 505
 None
 1.21A 1jtvA-4d8mA:
undetectable		 1jtvA-4d8mA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		5 / 12 ILE A 664
ILE A 678
VAL A 676
PHE A 674
LEU A 631
 None
 1.05A 1uduB-4d8mA:
undetectable		 1uduB-4d8mA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		5 / 12 ILE A 664
ILE A 678
VAL A 676
PHE A 674
LEU A 631
 None
 1.02A 1xozA-4d8mA:
2.5		 1xozA-4d8mA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		3 / 3 ASP A 430
PHE A 438
ARG A 420
 None
 0.89A 2a3aA-4d8mA:
undetectable		 2a3aA-4d8mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		4 / 8 ILE A 678
VAL A 591
TYR A 617
CYH A 615
 None
 1.29A 2xz5A-4d8mA:
undetectable
2xz5C-4d8mA:
undetectable		 2xz5A-4d8mA:
17.90
2xz5C-4d8mA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		4 / 8 ILE A 678
VAL A 591
TYR A 617
CYH A 615
 None
 1.26A 2xz5C-4d8mA:
undetectable
2xz5D-4d8mA:
undetectable		 2xz5C-4d8mA:
17.90
2xz5D-4d8mA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		5 / 12 ILE A 678
LEU A 688
PRO A 565
PHE A 627
VAL A 667
 None
 0.99A 2ygqA-4d8mA:
undetectable		 2ygqA-4d8mA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		4 / 5 ILE A 697
PHE A 674
PHE A 693
TYR A 611
 None
 1.38A 3em0A-4d8mA:
undetectable		 3em0A-4d8mA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		4 / 7 VAL A 386
ILE A 533
TYR A 516
ILE A 518
 None
 1.00A 3hgxA-4d8mA:
2.1		 3hgxA-4d8mA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		5 / 12 VAL A 591
LEU A 688
LEU A 580
ILE A 601
GLY A 600
 None
 1.04A 3kk6A-4d8mA:
undetectable		 3kk6A-4d8mA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		5 / 12 VAL A 591
LEU A 688
LEU A 580
ILE A 601
GLY A 600
 None
 1.06A 3kk6B-4d8mA:
undetectable		 3kk6B-4d8mA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		4 / 7 PRO A 350
ILE A 368
ILE A 533
ASN A 306
 None
 0.92A 3p50A-4d8mA:
4.5		 3p50A-4d8mA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		4 / 7 PRO A 350
ILE A 368
ILE A 533
ASN A 306
 None
 0.92A 3p50B-4d8mA:
5.2		 3p50B-4d8mA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		4 / 7 PRO A 350
ILE A 368
ILE A 533
ASN A 306
 None
 0.93A 3p50C-4d8mA:
5.1		 3p50C-4d8mA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		4 / 7 PRO A 350
ILE A 368
ILE A 533
ASN A 306
 None
 0.91A 3p50D-4d8mA:
5.1		 3p50D-4d8mA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		4 / 7 PRO A 350
ILE A 368
ILE A 533
ASN A 306
 None
 0.92A 3p50E-4d8mA:
5.2		 3p50E-4d8mA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		3 / 3 ASN A 605
ALA A 671
LYS A 608
 None
 0.96A 3runA-4d8mA:
undetectable		 3runA-4d8mA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		3 / 3 TYR A 264
ASP A 198
ASP A 191
 None
 0.79A 4a6eA-4d8mA:
undetectable		 4a6eA-4d8mA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		5 / 12 ILE A 276
LEU A 245
TRP A 323
ILE A 251
THR A 322
 None
 1.05A 4ej1B-4d8mA:
undetectable		 4ej1B-4d8mA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		4 / 5 GLY A 657
GLY A 654
ASN A 586
GLU A 646
 None
 1.19A 4fglC-4d8mA:
undetectable		 4fglC-4d8mA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		3 / 3 GLY A 527
GLU A 520
THR A 519
 None
 0.58A 4kouA-4d8mA:
undetectable		 4kouA-4d8mA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		5 / 12 ILE A 276
LEU A 245
TRP A 323
ILE A 251
THR A 322
 None
 1.05A 4x5jA-4d8mA:
undetectable		 4x5jA-4d8mA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		3 / 3 LEU A 317
ARG A 341
ARG A 582
 None
 0.86A 4yiaB-4d8mA:
undetectable		 4yiaB-4d8mA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		5 / 12 GLY A 531
PRO A 517
LEU A 515
ASN A 529
ARG A 460
 None
 1.36A 5emlA-4d8mA:
undetectable		 5emlA-4d8mA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		4 / 6 TYR A 573
ASP A 630
HIS A 677
ILE A 603
 None
 1.16A 5ih0A-4d8mA:
undetectable		 5ih0A-4d8mA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		4 / 8 TYR A 536
ILE A 343
TYR A 516
ILE A 391
 None
 0.82A 5mzrE-4d8mA:
5.3		 5mzrE-4d8mA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		3 / 3 GLY A 485
THR A 526
PRO A 416
 None
 0.66A 5v5zA-4d8mA:
undetectable		 5v5zA-4d8mA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		4 / 8 ARG A 428
GLU A 397
VAL A 537
GLN A 602
 None
 1.01A 6fbvD-4d8mA:
2.6		 6fbvD-4d8mA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA
(Bacillus
thuringiensis) 		5 / 12 PHE A 197
ASN A 201
HIS A 243
TYR A 247
ILE A 251
 None
 1.08A 6mxtA-4d8mA:
2.5		 6mxtA-4d8mA:
21.38