SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
5 / 12 GLY A 159
SER A 162
LEU A 132
LEU A  58
TYR A 154
PO4  A 401 ( 3.8A)
None
None
None
None
1.40A 1fm6D-4d8uA:
undetectable
1fm6D-4d8uA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
5 / 11 LEU A   3
GLY A 205
VAL A 189
LEU A 215
LEU A 174
None
1.12A 1mx1A-4d8uA:
undetectable
1mx1A-4d8uA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
5 / 11 THR A 315
LEU A 275
GLY A 289
VAL A 190
ILE A 313
LLP  A  51 ( 3.4A)
None
None
None
None
1.14A 1phgA-4d8uA:
undetectable
1phgA-4d8uA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_A_SAMA500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
5 / 10 GLY A 160
SER A 161
SER A 195
ASN A  50
GLN A  83
None
LLP  A  51 ( 3.4A)
LLP  A  51 ( 2.4A)
LLP  A  51 ( 3.1A)
LLP  A  51 ( 3.5A)
1.29A 2c2bA-4d8uA:
24.7
2c2bB-4d8uA:
23.3
2c2bA-4d8uA:
20.90
2c2bB-4d8uA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_B_SAMB500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
5 / 10 ASN A  50
GLN A  83
GLY A 160
SER A 161
SER A 195
LLP  A  51 ( 3.1A)
LLP  A  51 ( 3.5A)
None
LLP  A  51 ( 3.4A)
LLP  A  51 ( 2.4A)
1.24A 2c2bA-4d8uA:
24.7
2c2bB-4d8uA:
23.3
2c2bA-4d8uA:
20.90
2c2bB-4d8uA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_C_SAMC500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
5 / 10 GLY A 160
SER A 161
SER A 195
ASN A  50
GLN A  83
None
LLP  A  51 ( 3.4A)
LLP  A  51 ( 2.4A)
LLP  A  51 ( 3.1A)
LLP  A  51 ( 3.5A)
1.33A 2c2bC-4d8uA:
24.7
2c2bD-4d8uA:
23.3
2c2bC-4d8uA:
20.90
2c2bD-4d8uA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_D_SAMD500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
5 / 9 ASN A  50
GLN A  83
GLY A 160
SER A 161
SER A 195
LLP  A  51 ( 3.1A)
LLP  A  51 ( 3.5A)
None
LLP  A  51 ( 3.4A)
LLP  A  51 ( 2.4A)
1.24A 2c2bC-4d8uA:
24.7
2c2bD-4d8uA:
23.3
2c2bC-4d8uA:
20.90
2c2bD-4d8uA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_E_SAME500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
5 / 11 GLY A 160
SER A 161
SER A 195
ASN A  50
GLN A  83
None
LLP  A  51 ( 3.4A)
LLP  A  51 ( 2.4A)
LLP  A  51 ( 3.1A)
LLP  A  51 ( 3.5A)
1.22A 2c2bE-4d8uA:
23.3
2c2bF-4d8uA:
24.8
2c2bE-4d8uA:
20.90
2c2bF-4d8uA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_F_SAMF500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
5 / 10 ASN A  50
GLN A  83
GLY A 160
SER A 161
SER A 195
LLP  A  51 ( 3.1A)
LLP  A  51 ( 3.5A)
None
LLP  A  51 ( 3.4A)
LLP  A  51 ( 2.4A)
1.29A 2c2bE-4d8uA:
23.3
2c2bF-4d8uA:
24.7
2c2bE-4d8uA:
20.90
2c2bF-4d8uA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
4 / 7 ASP A 255
TYR A 256
ARG A 303
ALA A 293
None
1.28A 2e5dA-4d8uA:
2.4
2e5dB-4d8uA:
undetectable
2e5dA-4d8uA:
21.67
2e5dB-4d8uA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
4 / 7 ILE A  35
THR A 315
ILE A 299
GLY A 217
None
LLP  A  51 ( 3.4A)
None
None
0.90A 2v0mB-4d8uA:
undetectable
2v0mB-4d8uA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
4 / 5 LEU A 321
GLN A  77
THR A 288
HIS A 314
None
None
LLP  A  51 ( 4.5A)
None
1.19A 2zj0B-4d8uA:
3.2
2zj0B-4d8uA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
5 / 12 LEU A 234
SER A 161
SER A 193
LEU A 206
LEU A   3
None
LLP  A  51 ( 3.4A)
None
None
None
1.43A 2zlcA-4d8uA:
undetectable
2zlcA-4d8uA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
3 / 3 ASN A  79
HIS A  80
VAL A 158
LLP  A  51 (-3.6A)
LLP  A  51 (-4.8A)
None
0.65A 3elzB-4d8uA:
undetectable
3elzB-4d8uA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
5 / 12 GLY A 160
ALA A  85
ALA A  88
LEU A  70
SER A 162
None
1.06A 3p2kD-4d8uA:
undetectable
3p2kD-4d8uA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
5 / 12 VAL A  96
LEU A  93
ILE A 156
VAL A  59
LEU A  55
None
None
None
None
LLP  A  51 ( 3.7A)
1.18A 3w68A-4d8uA:
undetectable
3w68A-4d8uA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
4 / 6 GLY A  49
ASP A 284
PRO A 319
ARG A  82
LLP  A  51 ( 4.2A)
LLP  A  51 ( 4.7A)
None
None
1.25A 4lajA-4d8uA:
undetectable
4lajB-4d8uA:
undetectable
4lajA-4d8uA:
20.30
4lajB-4d8uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
5 / 12 ALA A  60
ALA A 163
MET A 167
GLY A 165
PHE A  57
None
1.04A 4r29A-4d8uA:
undetectable
4r29A-4d8uA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
5 / 12 ALA A  60
ALA A 163
MET A 167
GLY A 165
PHE A  57
None
1.09A 4r29B-4d8uA:
undetectable
4r29B-4d8uA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
5 / 12 ALA A  60
ILE A 238
ALA A 163
GLY A 165
PHE A  57
None
1.00A 4r29D-4d8uA:
undetectable
4r29D-4d8uA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
3 / 3 ASN A 305
SER A 187
ARG A  33
None
0.87A 5b2qA-4d8uA:
2.8
5b2qA-4d8uA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
5 / 12 ALA A 196
GLY A 201
GLY A 197
SER A 161
GLU A 207
None
None
LLP  A  51 ( 4.2A)
LLP  A  51 ( 3.4A)
None
1.06A 5c0oH-4d8uA:
undetectable
5c0oH-4d8uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
5 / 11 VAL A 263
ILE A 103
TYR A 110
GLN A  77
ILE A  76
None
1.21A 5d75A-4d8uA:
undetectable
5d75A-4d8uA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
4 / 8 ILE A  76
TYR A 261
VAL A  81
ASP A 120
None
1.15A 5vlmF-4d8uA:
undetectable
5vlmF-4d8uA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
5 / 9 ILE A 238
SER A 193
SER A 161
SER A 162
GLY A 165
None
None
LLP  A  51 ( 3.4A)
None
None
1.35A 6awpA-4d8uA:
undetectable
6awpA-4d8uA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMM_A_SALA303_0
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica)
5 / 9 HIS A  80
SER A 195
ASN A  50
LEU A  58
LEU A  55
LLP  A  51 (-4.8A)
LLP  A  51 ( 2.4A)
LLP  A  51 ( 3.1A)
None
LLP  A  51 ( 3.7A)
1.45A 6emmA-4d8uA:
2.7
6emmA-4d8uA:
17.46