SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4d9r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 None
 0.78A 1aq7A-4d9rA:
34.9		 1aq7A-4d9rA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		4 / 8 ASP A 189
SER A 195
VAL A 213
GLY A 226
 None
 0.30A 1f5lA-4d9rA:
15.0		 1f5lA-4d9rA:
32.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 12 VAL A 212
LEU A 104
LEU A 103
SER A  94
GLU A  60
 None
 1.32A 1kw0A-4d9rA:
undetectable		 1kw0A-4d9rA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 12 VAL A 212
LEU A 104
LEU A 103
SER A  94
GLU A  60
 None
 1.32A 1mmkA-4d9rA:
undetectable		 1mmkA-4d9rA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 11 VAL A 212
LEU A 104
LEU A 103
SER A  94
GLU A  60
 None
 1.32A 1mmtA-4d9rA:
undetectable		 1mmtA-4d9rA:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 None
 0.61A 1tnlA-4d9rA:
16.3		 1tnlA-4d9rA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H9T_H_SVRH301_1
(THROMBIN)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 11 HIS A  91
PRO A  92
TRP A 237
VAL A 241
GLU A  49
 None
 1.33A 2h9tH-4d9rA:
18.4		 2h9tH-4d9rA:
30.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		4 / 5 ALA A 235
TRP A 124
LEU A 209
ALA A 232
 None
 1.30A 2jstA-4d9rA:
undetectable
2jstB-4d9rA:
undetectable		 2jstA-4d9rA:
13.66
2jstB-4d9rA:
13.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 None
 0.53A 2otvA-4d9rA:
16.5		 2otvA-4d9rA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 12 ASP A 189
SER A 195
VAL A 213
GLY A 226
TYR A 228
 None
 0.32A 2p16A-4d9rA:
15.5		 2p16A-4d9rA:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 None
 0.63A 2vinA-4d9rA:
13.8		 2vinA-4d9rA:
32.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 12 ASP A 189
SER A 195
VAL A 213
GLY A 226
TYR A 228
 None
 0.25A 2w26A-4d9rA:
14.1		 2w26A-4d9rA:
32.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		4 / 5 VAL A  45
TYR A  29
VAL A 200
ASP A 137
 None
 1.17A 2x45A-4d9rA:
undetectable		 2x45A-4d9rA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		4 / 5 VAL A  45
TYR A  29
VAL A 200
ASP A 137
 None
 1.10A 2x45C-4d9rA:
undetectable		 2x45C-4d9rA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 11 THR A  98
ILE A  99
THR A 177
LEU A 180
THR A 214
 None
 1.13A 3bexC-4d9rA:
undetectable
3bexD-4d9rA:
undetectable		 3bexC-4d9rA:
19.47
3bexD-4d9rA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 11 THR A 177
LEU A 180
THR A 214
THR A  98
ILE A  99
 None
 1.13A 3bexE-4d9rA:
undetectable
3bexF-4d9rA:
undetectable		 3bexE-4d9rA:
19.47
3bexF-4d9rA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 11 THR A  98
ILE A  99
THR A 177
LEU A 180
THR A 214
 None
 1.22A 3bf1A-4d9rA:
undetectable
3bf1B-4d9rA:
undetectable		 3bf1A-4d9rA:
19.47
3bf1B-4d9rA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 12 THR A 177
LEU A 180
THR A 214
THR A  98
ILE A  99
 None
 1.23A 3bf1A-4d9rA:
undetectable
3bf1B-4d9rA:
undetectable		 3bf1A-4d9rA:
19.47
3bf1B-4d9rA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 11 THR A  98
ILE A  99
THR A 177
LEU A 180
THR A 214
 None
 1.12A 3bf1C-4d9rA:
undetectable
3bf1D-4d9rA:
undetectable		 3bf1C-4d9rA:
19.47
3bf1D-4d9rA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 11 THR A 177
LEU A 180
THR A 214
THR A  98
ILE A  99
 None
 1.17A 3bf1C-4d9rA:
undetectable
3bf1D-4d9rA:
undetectable		 3bf1C-4d9rA:
19.47
3bf1D-4d9rA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 11 THR A  98
ILE A  99
THR A 177
LEU A 180
THR A 214
 None
 1.13A 3bf1E-4d9rA:
undetectable
3bf1F-4d9rA:
undetectable		 3bf1E-4d9rA:
19.47
3bf1F-4d9rA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 11 THR A 177
LEU A 180
THR A 214
THR A  98
ILE A  99
 None
 1.13A 3bf1E-4d9rA:
undetectable
3bf1F-4d9rA:
undetectable		 3bf1E-4d9rA:
19.47
3bf1F-4d9rA:
19.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 11 HIS A  91
PRO A  92
TRP A 237
VAL A 241
GLU A  49
 None
 1.24A 3bf6H-4d9rA:
18.1		 3bf6H-4d9rA:
30.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 10 ILE A 176
LEU A 199
VAL A 213
VAL A 138
LEU A 160
 None
 1.06A 3gwxA-4d9rA:
undetectable		 3gwxA-4d9rA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA279_0
(UNIVERSAL STRESS
PROTEIN)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		4 / 4 SER A 190
SER A 195
THR A 214
SER A 215
 None
 1.31A 3loqA-4d9rA:
undetectable		 3loqA-4d9rA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		3 / 3 SER A 154
SER A  72
HIS A  40
 None
 0.81A 3mzeA-4d9rA:
undetectable		 3mzeA-4d9rA:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 None
 0.71A 3rxhA-4d9rA:
16.5		 3rxhA-4d9rA:
37.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		4 / 4 LEU A 199
GLY A 211
LEU A 209
GLU A 210
 None
 1.09A 3tgvB-4d9rA:
2.8		 3tgvB-4d9rA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 11 GLY A 115
ALA A 112
LEU A  68
GLY A  69
ALA A  56
 None
 1.05A 4l6v1-4d9rA:
undetectable
4l6v6-4d9rA:
undetectable		 4l6v1-4d9rA:
15.21
4l6v6-4d9rA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		3 / 3 ARG A 179
HIS A 101
SER A 233
 None
 0.90A 4mjwA-4d9rA:
undetectable
4mjwB-4d9rA:
undetectable		 4mjwA-4d9rA:
18.93
4mjwB-4d9rA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		3 / 3 SER A 233
ARG A 179
HIS A 101
 None
 0.90A 4mjwA-4d9rA:
undetectable
4mjwB-4d9rA:
undetectable		 4mjwA-4d9rA:
18.93
4mjwB-4d9rA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		4 / 5 GLY A  43
LEU A 209
LEU A 103
LEU A 108
 None
 0.87A 4o8fA-4d9rA:
undetectable		 4o8fA-4d9rA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		4 / 5 ILE A 143
HIS A 157
TYR A 228
VAL A 213
 None
 1.36A 4s0vA-4d9rA:
undetectable		 4s0vA-4d9rA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		4 / 7 LEU A 105
VAL A  85
GLN A  50
GLU A  49
 None
 1.04A 5tudA-4d9rA:
undetectable		 5tudA-4d9rA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 12 ALA A  55
VAL A  33
GLY A 140
ALA A 139
LEU A 160
 None
 1.09A 5xxiA-4d9rA:
undetectable		 5xxiA-4d9rA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 4d9r COMPLEMENT FACTOR D
(Homo
sapiens) 		5 / 12 GLY A  19
SER A 215
VAL A 213
VAL A 138
ASP A 137
 None
 1.32A 6bxlB-4d9rA:
undetectable		 6bxlB-4d9rA:
21.14