SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4da1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 116
ALA A 193
LEU A 293
VAL A 342
LEU A  92
 None
 1.26A 1s9pB-4da1A:
undetectable		 1s9pB-4da1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASP A 266
GLY A 187
VAL A 254
GLY A 207
VAL A 206
 None
 1.09A 2avsB-4da1A:
undetectable		 2avsB-4da1A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 258
LEU A 269
GLY A 265
CYH A 138
ALA A 190
 None
 1.23A 2bm9B-4da1A:
undetectable		 2bm9B-4da1A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 258
LEU A 269
GLY A 265
CYH A 138
ALA A 190
 None
 1.19A 2bm9C-4da1A:
undetectable		 2bm9C-4da1A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 258
LEU A 269
GLY A 265
CYH A 138
ALA A 190
 None
 1.14A 2br4C-4da1A:
undetectable		 2br4C-4da1A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 SER A 209
ASN A 301
THR A 191
LEU A 222
ILE A 212
 None
 1.28A 2xrlA-4da1A:
undetectable		 2xrlA-4da1A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ALA A 341
SER A 339
THR A 296
VAL A 294
 None
 1.04A 3d2tB-4da1A:
undetectable		 3d2tB-4da1A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ASP A 208
VAL A 206
ILE A 264
GLY A 187
THR A 261
 None
 1.17A 3el4B-4da1A:
undetectable		 3el4B-4da1A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 PRO A 252
VAL A 244
THR A 189
GLY A 207
 None
 1.07A 3elzB-4da1A:
1.6		 3elzB-4da1A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ARG A 104
ASP A 127
ASP A 298
ASP A 208
 None
MG  A 504 ( 2.6A)
MG  A 504 (-2.8A)
None
 1.45A 3naiA-4da1A:
undetectable		 3naiA-4da1A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_B_URFB521_1
(RNA DEPENDENT RNA
POLYMERASE)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ARG A 104
ASP A 127
ASP A 298
ASP A 208
 None
MG  A 504 ( 2.6A)
MG  A 504 (-2.8A)
None
 1.25A 3naiB-4da1A:
undetectable		 3naiB-4da1A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ARG A 104
ASP A 127
ASP A 298
ASP A 208
 None
MG  A 504 ( 2.6A)
MG  A 504 (-2.8A)
None
 1.28A 3naiC-4da1A:
undetectable		 3naiC-4da1A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 PRO A 219
SER A 306
ILE A 309
VAL A 294
PHE A 292
 None
 1.36A 3rf4A-4da1A:
undetectable
3rf4C-4da1A:
undetectable		 3rf4A-4da1A:
17.18
3rf4C-4da1A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 PRO A 219
SER A 306
ILE A 309
VAL A 294
PHE A 292
 None
 1.34A 3rf4A-4da1A:
undetectable
3rf4B-4da1A:
undetectable		 3rf4A-4da1A:
17.18
3rf4B-4da1A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 PRO A 219
SER A 306
ILE A 309
VAL A 294
PHE A 292
 None
 1.35A 3rf4B-4da1A:
undetectable
3rf4C-4da1A:
undetectable		 3rf4B-4da1A:
17.18
3rf4C-4da1A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 130
GLY A 265
ALA A 134
ALA A 190
SER A 205
 None
 0.94A 3sudA-4da1A:
undetectable		 3sudA-4da1A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 125
ALA A 124
GLY A 207
ASP A 109
THR A 297
 None
None
None
MG  A 504 ( 4.7A)
None
 1.11A 4mm8A-4da1A:
undetectable		 4mm8A-4da1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 THR A 296
LEU A 295
THR A 223
LEU A 222
 None
 0.87A 4z91F-4da1A:
undetectable
4z91G-4da1A:
undetectable
4z91H-4da1A:
undetectable
4z91I-4da1A:
undetectable
4z91J-4da1A:
undetectable		 4z91F-4da1A:
21.63
4z91G-4da1A:
21.63
4z91H-4da1A:
21.63
4z91I-4da1A:
21.63
4z91J-4da1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 VAL A 343
ALA A  98
ILE A 300
THR A 327
 None
 1.03A 5e4dB-4da1A:
undetectable		 5e4dB-4da1A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 285
GLY A 198
LEU A 194
GLU A 200
LEU A 156
 None
 1.19A 5nwvA-4da1A:
undetectable		 5nwvA-4da1A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A 160
VAL A 192
CYH A 145
CYH A 138
 None
None
BME  A 502 (-2.0A)
None
 1.28A 5te0A-4da1A:
undetectable		 5te0A-4da1A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 292
VAL A 343
ALA A  98
ALA A 323
GLY A  96
 None
None
None
None
BME  A 501 ( 4.5A)
 1.39A 5tzoA-4da1A:
undetectable		 5tzoA-4da1A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ALA A 341
THR A 340
GLN A 329
VAL A 326
 None
 0.97A 6cduA-4da1A:
undetectable
6cduE-4da1A:
undetectable		 6cduA-4da1A:
21.36
6cduE-4da1A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 VAL A 120
LEU A 156
TYR A 122
LEU A 149
LEU A 150
 None
 1.04A 6f6nA-4da1A:
0.0
6f6nB-4da1A:
undetectable		 6f6nA-4da1A:
12.78
6f6nB-4da1A:
13.48